Abstract：
:Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon contributes to the well-known age-associated increase in the occurrence of many cancers in the elderly. However, should the immune system be important in controlling cancer, for which there is a great deal of evidence, it is logical to propose that dysfunctional immunity in the elderly would contribute to compromised immunosurveillance and increased cancer occurrence. The chronological age at which immunosenescence becomes clinically important is known to be influenced by many factors, including the pathogen load to which individuals are exposed throughout life. It is proposed here that the cancer antigen load may have a similar effect on "immune exhaustion" and that pathogen load and tumor load may act additively to accelerate immunosenescence. Understanding how and why immune responsiveness changes in humans as they age is essential for developing strategies to prevent or restore dysregulated immunity and assure healthy longevity, clearly possible only if cancer is avoided. Here, we provide an overview of the impact of age on human immune competence, emphasizing T-cell-dependent adaptive immunity, which is the most sensitive to ageing. This knowledge will pave the way for rational interventions to maintain or restore appropriate immune function not only in the elderly but also in the cancer patient.
journal_name
Immun Ageingjournal_title
Immunity & ageing : I & Aauthors
Derhovanessian E,Solana R,Larbi A,Pawelec Gdoi
10.1186/1742-4933-5-11subject
Has Abstractpub_date
2008-09-24 00:00:00pages
11issn
1742-4933pii
1742-4933-5-11journal_volume
5pub_type
杂志文章abstract：:The age-related dysregulation and decline of the immune system-collectively termed "immunosenescence"-has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinate...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章,评审
doi：10.1186/s12979-019-0164-9
更新日期：2019-09-13 00:00:00
abstract：BACKGROUND:There is strong evidence that an individual's genetic background is an important predisposing factor to longevity. In the present study we analysed the frequency of HLA class I, class II, as well as the TNF-alpha -308 polymorphism that may be related to an increased life span in Mexican Mestizo healthy elder...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-2-13
更新日期：2005-11-03 00:00:00
abstract：BACKGROUND:The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin olive oil, common to all Mediterranean countries. Olive oil is the main source of fat and can modu...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-016-0067-y
更新日期：2016-04-05 00:00:00
abstract：:Streptococcus pneumoniae is a serious worldwide pathogen and the focus of numerous vaccine development projects. Currently the most widely accepted surrogate marker for evaluating the efficacy of a given vaccine is to utilize ELISA. Measurement of antibody concentration by ELISA without reduction in cross-reactive ant...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-2-10
更新日期：2005-06-27 00:00:00
abstract：Background:Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune res...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-019-0146-y
更新日期：2019-02-23 00:00:00
abstract：BACKGROUND:Neurodegenerative disorders such Alzheimer's disease (AD) are often characterized by senile plaques and neurofibrillary tangle. In addition, reactive astrogliosis, microglia activation and a chronic inflammation are found in AD brain. Activated microglia has been reported to express a large number of beta ch...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-10-6
更新日期：2013-02-21 00:00:00
abstract：BACKGROUND:Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence th...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-015-0031-2
更新日期：2015-05-20 00:00:00
abstract：Background:Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clinical subtypes of late AMD. Results:We sampled fresh venous blood from patients with geographic atrop...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-019-0160-0
更新日期：2019-08-15 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12979-018-0122-y.]. ...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章,已发布勘误
doi：10.1186/s12979-018-0123-x
更新日期：2018-08-21 00:00:00
abstract：:Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or neurodegenerative diseases among the elderly. CDD are of complex diagnosis, difficult to treat and absorbing an ...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-7-S1-S1
更新日期：2010-12-16 00:00:00
abstract：BACKGROUND:Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. However, although CMV infection occurs during childhood, relatively little is know about the typical quantity and quality of T cell responses in pediatric ...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-3-11
更新日期：2006-12-08 00:00:00
abstract：BACKGROUND:The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome by cellular stress leads to activation of the inflammasome, and NLRP3 gene polymorphisms have been associated with autoinflammatory diseases. Inflammasomes have also been implicated in the initiation or progression of metabolic disor...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-015-0047-7
更新日期：2015-10-31 00:00:00
abstract：:In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's D...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-019-0147-x
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians. RESULTS:We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLRY and YSPTLFY...
journal_title：Immunity & ageing : I & A
pub_type：
doi：10.1186/s12979-016-0064-1
更新日期：2016-03-22 00:00:00
abstract：BACKGROUND:Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Ma...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-016-0074-z
更新日期：2016-05-31 00:00:00
abstract：BACKGROUND:Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bone marrow (BM) microenvironment. Multiparameter flow cytometry (MFC) allows the simultaneous study of...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-015-0032-1
更新日期：2015-06-04 00:00:00
abstract：BACKGROUND:CD90 (Thy-1) is a small glycoprotein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells, and is often used as a marker in adoptive transfer experiments to distinguish donor and recipient T cells with different CD90 subtypes. We have performed adoptive transfer experiments...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-10-36
更新日期：2013-08-19 00:00:00
abstract：BACKGROUND:Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhesion, and resolution of inflammation in patients with neovascular age-related macular degeneration (...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-017-0100-9
更新日期：2017-07-27 00:00:00
abstract：BACKGROUND:The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a good candidate, since vitamin A concentrations classically decrease during aging whereas it may poss...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-7-10
更新日期：2010-08-20 00:00:00
abstract：:ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with d...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章,评审
doi：10.1186/1742-4933-11-16
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Ageing brings about the gradual deterioration of the immune system, also known as immunosenescence. The role of non-coding circular RNA in immunosenescence is under studied. Using circular RNA microarray data, we assembled Comparison groups (C1, C2, C3 and C4) that allowed us to compare the circular RNA expr...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-015-0042-z
更新日期：2015-10-08 00:00:00
abstract：:The emergence of SARS-CoV-2 and its inordinately rapid spread is posing severe challenges to the wellbeing of millions of people worldwide, health care systems and the global economy. While many younger people experience no or mild symptoms on infection, older adults are highly susceptible to life-threatening respirat...
journal_title：Immunity & ageing : I & A
pub_type： 社论
doi：10.1186/s12979-020-00180-2
更新日期：2020-04-11 00:00:00
abstract：BACKGROUND:Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiologic mechanisms remain elusive and clinical studies on the relationship between inflammatory markers a...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-020-00211-y
更新日期：2020-12-21 00:00:00
abstract：BACKGROUND:Since the COVID-19 outbreak an unprecedented challenge for healthcare systems around the world has been placed. In Cuba, the first case of COVID-19 was reported on March 11. Elderly with multiple comorbidities have been the most risky population. Although most patients present a mild to moderate disease, som...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-020-00207-8
更新日期：2020-11-14 00:00:00
abstract：: The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of "successful and u...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-9-8
更新日期：2012-04-23 00:00:00
abstract：:The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. These two experimental models will be comp...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-4-7
更新日期：2007-09-29 00:00:00
abstract：: Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 com...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-7-6
更新日期：2010-05-27 00:00:00
abstract：Background:Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. M...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/s12979-018-0126-7
更新日期：2018-09-08 00:00:00
abstract：BACKGROUND:The age-related weakening of the immune system makes elderly subjects less responsive to influenza vaccination. In the last years, two "enhanced vaccines" were licensed for individuals aged ≥65 years, one being a subunit vaccine (Fluad®) containing the MF59 adjuvant administered intramuscularly (IM-MF59) and...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-11-10
更新日期：2014-05-16 00:00:00
abstract：BACKGROUND:Sarcopenia is an important cause of morbidity and mortality in older adults, with immunosenescence and inflammation being possible underlying mechanisms. We investigated the relationship between latent cytomegalovirus (CMV) infection, Interleukin 6 (IL-6) levels, muscle size and strength in a group of health...
journal_title：Immunity & ageing : I & A
pub_type： 杂志文章
doi：10.1186/1742-4933-10-33
更新日期：2013-08-13 00:00:00
