Alteration of fexofenadine disposition in the rat isolated perfused liver following injection of bacterial lipopolysaccharide.

abstract：:Vancomycin is an antibiotic used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus. In the last decades, vancomycin has been widely used in hospital environments due to the increasing incidence of sepsis and septic shock. Sepsis ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zamoner W,Prado IRS,Balbi AL,Ponce D

更新日期：2019-04-01 00:00:00

abstract：:Autophagy promotes cell survival or induces apoptosis in cancer cells. While SIRT1 and AMPK induce autophagy in both normal and cancer cells, Akt and mTOR can inhibit it. Calycosin, a methoxyisoflavone, protects against several types of solid tumours including colorectal cancer. However, the mechanisms behind the anti...

journal_title：Clinical and experimental pharmacology & physiology

authors： El-Kott AF,Al-Kahtani MA,Shati AA

更新日期：2019-10-01 00:00:00

abstract：:1. The present study investigates the contribution of the sympathetic and vagal parasympathetic systems to the tachycardic response of long-lasting (40 min) conditioned fear responses to context. 2. The conditioned fear response evoked by re-exposure to a footshock chamber was tested 10 min after intravenous injection...

journal_title：Clinical and experimental pharmacology & physiology

authors： Carrive P

更新日期：2006-12-01 00:00:00

abstract：:1. The chronotropic and inotropic effects of the anti-anginal agent SG-75 (2-nicotinamidoethyl nitrate) and 1-verapamil were investigated in isolated blood-perfused canine atrial preparations. The compounds were administered via the cannulated sinus node artery. 2. SG-75 induced a selective negative inotropic as oppos...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chiba S,Furukawa Y,Kobayashi M

更新日期：1980-03-01 00:00:00

abstract：:1. Using a nested case-control study of 661 non-institutionalized elderly (> or = 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT1) receptor gene is associated with hypertension in the elderly. 2. Individua...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liyou N,Davis D,James K,Simons L,Friedlander Y,Simons J,McCallum J,Johnson A

更新日期：1999-07-01 00:00:00

abstract：:1. The common pathological alteration in virtually every progressive chronic kidney disease (CKD) is renal fibrosis. 2. This review focuses on some growth factors, which are particularly well-established in contributing to fibrosis, such as the profibrotic, transforming growth factor-β, and connective tissue growth fa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boor P,Floege J

更新日期：2011-07-01 00:00:00

abstract：:1. The antitumour effect of orally administered cordycepin, a component isolated from water extracts of Cordyceps sinensis, was examined in mice inoculated with B16 melanoma (B16-BL6) cells. 2. B16-BL6 (1 x 10(6)) cells were inoculated subcutaneously into the right footpad of mice. At 2 weeks after the cell inoculatio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yoshikawa N,Nakamura K,Yamaguchi Y,Kagota S,Shinozuka K,Kunitomo M

更新日期：2004-12-01 00:00:00

abstract：:1. This study investigated the effect of atrial natriuretic peptide on renin release from the kidney. The in vitro direct effect was examined in the animal experiment using renal cortical slices of rat, and the in vivo effect was observed in the human infusion study. 2. In the in vitro experiments, alpha-human atrial ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ishimitsu T,Hirata Y,Matsuoka H,Ishii M,Sugimoto T,Kangawa K,Matsuo H

更新日期：1992-10-01 00:00:00

abstract：:1. We have tested the effects of 2 month oral treatment with the KATP opener, nitric oxide (NO) donor and anti-oxidant molecule nicorandil (0.1 mg/kg per day) on major physiological parameters and heart function of 4-, 12- and 24-month-old rats. 2. Several methods were used: (i) measurement of blood pressure using a n...

journal_title：Clinical and experimental pharmacology & physiology

authors： Garnier-Raveaud S,Faury G,Mazenot C,Cand F,Godin-Ribuot D,Verdetti J

更新日期：2002-05-01 00:00:00

abstract：:1. Sevoflurane produces QT prolongation on the electrocardiogram, predominantly via inhibition of the slow delayed rectifier K(+) current. DPI 201-106 is an experimental drug that produces QT prolongation by reducing Na(+) channel inactivation, thereby mimicking congenital long QT syndrome type 3 (LQT3). The present s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kang J,Chen XL,Reynolds WP,Rampe D

更新日期：2007-12-01 00:00:00

abstract：:1. Several selective antagonists are available to differentiate between muscarinic receptors. 2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors. 3. Reasons for differences between affinity constants determined in functional and binding studies a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mitchelson F,Choo LK,Darroch S

更新日期：1989-06-01 00:00:00

abstract：:This study investigates the effect of chronic consumption of a high-fat diet rich in corn oil (CO-HFD) on atrial cells ultrastructure, antioxidant levels and markers of intrinsic cell death of both control and type 1 diabetes mellitus (T1DM)-induced rats. Adult male rats (10 rats/group) were divided into four groups: ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Eid RA,Eleawa SM,Alkhateeb MA,Aldera H,Zaki MSA,Al-Shraim M,Saeed MA,El-Kott AF,Alaa Eldeen M,Alassiri M,Alshehri MM,Salem Al-Shudiefat AA,Khalil MA

更新日期：2019-12-01 00:00:00

abstract：:Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is estimated that skeletal muscle is responsible for ~80% of insulin-mediated glucose disposal in the post-prandial period. The classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin recepto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Keske MA,Dwyer RM,Russell RD,Blackwood SJ,Brown AA,Hu D,Premilovac D,Richards SM,Rattigan S

更新日期：2017-01-01 00:00:00

abstract：:1. The aim of the present study was to investigate the role of dopamine (DA) in the hypotensive and renal effects of L-arginine during extracellular fluid volume expansion (10% bodyweight). 2. Animals were randomized to non-expanded and expanded groups. Both groups received different treatments: L-arginine (250 mg/kg,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Costa Mde L,Loria A,Marchetti M,Balaszczuk AM,Arranz CT

更新日期：2002-09-01 00:00:00

abstract：:Ventilation to one lobe of lung was reduced in anaesthetized open-chest cats and dogs to simulate the ventilation/perfusion (V/Q) mismatching of chronic lung disease. Blood flow to this lobe fell less than ventilation; thus lobar V/Q diminished. In seven cats almitrine (0.5 mg/kg + 10 micrograms/kg per min, i.v.) caus...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wach RA,Gill GW,Suggett AJ,Bee D,Barer G

更新日期：1986-06-01 00:00:00

abstract：:1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large transverse tubules throughout the cell. These structures are regula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lüllmann H,Peters T

更新日期：1977-01-01 00:00:00

abstract：:The activation of inactive renin during incubation of human plasma with puff adder venom at pH 7.4 was found to be a complex process. Gel filtration on Sephacryl S-200 indicated that the venom contains a major peak of caseinolytic and renin-activating activity of low molecular weight. This enzyme was a metalloproteina...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris BJ,Lawrence CH,Catanzaro DF

更新日期：1980-09-01 00:00:00

abstract：:Chronic low back pain (LBP) has high prevalence in the adult population which is associated with enormous disability. Hence, our aim was to further characterise our LBP rat model by using immunohistological and immunohistochemical methods at an advanced stage (day 49) of the model. Male Sprague-Dawley rats were anaest...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park TSW,Khan N,Kuo A,Nicholson JR,Corradini L,Smith MT

更新日期：2020-09-05 00:00:00

abstract：:1. Direct cortical stimulation of motor and sensory areas of the cortex in experimental animals and some neurosurgical patients has provided much useful physiological information. Some of the benefits of this approach can be provided in awake volunteer subjects using new techniques which activate the motor cortex thor...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gandevia SC

更新日期：1996-10-01 00:00:00

abstract：:1. The aim of this study was to assess the vagal and sympathetic nerve contribution to the relationship between mean arterial pressure (MAP) and heart rate (HR) at 6, 9, 14 and 20 weeks of age in conscious Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with methoxamine- and nitroprusside-induced steady-s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA,Adams MA

更新日期：1988-04-01 00:00:00

abstract：:1. Triiodothyronine (T3; 1.0 mg/kg per day subcutaneously) was administered to 10 dogs for 14 days; 10 saline-treated dogs served as controls. T3-treated dogs showed the expected physiological responses of hyperthyroidism; further, chronotropic responses to isoprenaline in vivo were significantly increased in T3-treat...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hoey A,Brown L,Marchant C,Atwell R,Sernia C

更新日期：1992-11-01 00:00:00

abstract：:1. Dexamethasone (Dex)-induced hypertension is characterized by endothelial dysfunction associated with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic properties that have been reported to improve endothelial function through increased availability of N...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mondo CK,Yang WS,Zhang N,Huang TG

更新日期：2006-11-01 00:00:00

abstract：:1. Oxidative stress plays a role in senescence-associated organ deterioration. This is supported by the beneficial effects of anti-oxidants against ageing-related organ damage, although their role in cardiac ageing has not been elucidated. 2. The aim of the present study was to examine the impact of cardiac-specific o...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wu S,Li Q,Du M,Li SY,Ren J

更新日期：2007-01-01 00:00:00

abstract：:1. The present study examined the cytosolic Ca(2+) regulatory machinery involved in the vasorelaxation produced by petasin, a sesquiterpene isolated from Petasites formosanus. 2. Aortic rings isolated from Sprague-Dawley rats were exposed to petasin (0.01-100 micromol/L) to elucidate its vascular effects on isometric ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang GJ,Lin YL,Chen CH,Wu XC,Liao JF,Ren J

更新日期：2010-03-01 00:00:00

abstract：:1. Ghrelin is a multifunctional peptide hormone that affects various processes, including growth hormone and insulin release, appetite regulation, gut motility, metabolism and cancer cell proliferation. Ghrelin is produced in the stomach and in other normal and pathological cell types. It may act as an endocrine or au...

journal_title：Clinical and experimental pharmacology & physiology

authors： Seim I,Amorim L,Walpole C,Carter S,Chopin LK,Herington AC

更新日期：2010-01-01 00:00:00

abstract：:1. mu-Opioid receptor agonists mediate their central analgesic effects by actions on neurons within brain regions such as the mid-brain periaqueductal grey (PAG). Within the PAG, mu-opioid receptor-mediated analgesia results from inhibition of GABAergic influences on output projection neurons. We have established that...

journal_title：Clinical and experimental pharmacology & physiology

authors： Christie MJ,Connor M,Vaughan CW,Ingram SL,Bagley EE

更新日期：2000-07-01 00:00:00

abstract：:1. The effect of enalapril on handling of an Na load and on body Na during 96 h of zero Na intake was measured in hypertensive rats (GH and SHR) and their normotensive controls (N and WKY) by a whole body counting method. 2. Enalapril treatment led to a greater fall in body Na in the first 24 h after the Na load (as e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ledingham JM,Simpson FO

更新日期：1992-05-01 00:00:00

abstract：:1. The ethyl acetate (EtOAc) extract and 3-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-d-glucose (3OG46HG) of Euphorbia thymifolia Linnea have been shown to exhibit anti-herpes simplex virus (HSV)-2 activity in vitro. In the present study, we investigated the mode of action of these two compounds in suppressing HSV-2 multi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang CM,Cheng HY,Lin TC,Chiang LC,Lin CC

更新日期：2005-05-01 00:00:00

abstract：:1. We examined the effects of torasemide (0.3 and 1 mg/kg i.v.) on renal haemodynamics and function employing renal clearance and stop-flow techniques in anaesthetized dogs and compared these with furosemide (1 and 3 mg/kg i.v.). 2. Torasemide and furosemide did not influence renal haemodynamics, in the renal clearanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Uchida T,Hayashi K,Suzuki Y,Matsumura Y

更新日期：1991-07-01 00:00:00

abstract：:1. Econazole is used clinically as an antifungal drug with many different in vitro effects. However, the effects of econazole on prostate cancer cells are unknown. The effects of econazole on intracellular Ca2+ concentrations ([Ca2+]i) in and the proliferation of human PC3 prostate cancer cells was explored in the pre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Huang JK,Liu CS,Chou CT,Liu SI,Hsu SS,Chang HT,Hsieh CH,Chang CH,Chen WC,Jan CR

更新日期：2005-09-01 00:00:00