Neurotransmitter role of endogenous morphine in CNS.

Abstract:

:Endogenous morphine is present in the mammalian brain as determined by gas chromatography/mass spectrometry. The criteria essential for satisfying the definition of morphine as a neurotransmitter are examined. The detection of endogenous morphine-like compounds inside brain neurons by immunocytochemistry and the Ca(+) dependent release of endogenous morphine from rat brain slices provide evidence for its transmitter status. Indirect evidence that endogenous morphine modulates thermonociception and weakens memory through mu opioid receptors again supports a neurotransmitter role for this chemical messenger. Evidence has been found for its endogenous synthesis in animal tissues as well. These findings indicate that endogenous morphine might function as neuromodulator/neurotransmitter agent in the CNS.

journal_name

Med Sci Monit

authors

Guarna M,Ghelardini C,Galeotti N,Stefano GB,Bianchi E

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

RA190-193

issue

6

eissn

1234-1010

issn

1643-3750

pii

7467

journal_volume

11

pub_type

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