Endostatin inhibits VEGF-A induced osteoclastic bone resorption in vitro.

Abstract:

BACKGROUND:Endostatin is a C-terminal fragment of collagen XVIII which is a component of basement membranes with the structural properties of both collagens and proteoglycans. Endostatin has a major role in angiogenesis which is intimately associated with bone development and remodeling. Signaling between the endothelial cells and the bone cells, for example, may have a role in recruitment of osteoclastic precursor cells. Our study aims at exploring a possibility that endostatin, either as a part of basement membrane or as a soluble molecule, may control osteoclastogenesis and osteoclastic bone resorption in vitro. METHODS:Rat pit formation assay was employed in order to examine the effect of endostatin alone or in combination with vascular endothelial growth factor-A (VEGF-A) on bone resorption in vitro. Effect of these agents on osteoclast differentiation in vitro was also tested. Osteoclastogenesis and the number of osteoclasts were followed by tartrate resistant acid phosphatase (TRACP) staining and resorption was evaluated by measuring the area of excavated pits. RESULTS:Endostatin inhibited the VEGF-A stimulated osteoclastic bone resorption, whereas endostatin alone had no effect on the basal resorption level in the absence of VEGF-A. In addition, endostatin could inhibit osteoclast differentiation in vitro independent of VEGF-A. CONCLUSION:Our in vitro data indicate that collagen XVIII/endostatin can suppress VEGF-A induced osteoclastic bone resorption to the basal level. Osteoclastogenesis is also inhibited by endostatin. The regulatory effect of endostatin, however, is not critical since endostatin alone does not modify the basal bone resorption.

authors

Sipola A,Nelo K,Hautala T,Ilvesaro J,Tuukkanen J

doi

10.1186/1471-2474-7-56

subject

Has Abstract

pub_date

2006-07-13 00:00:00

pages

56

issn

1471-2474

pii

1471-2474-7-56

journal_volume

7

pub_type

杂志文章
  • Internalised stigma in people with rheumatoid arthritis: a cross sectional study to establish the psychometric properties of the ISMI-RA.

    abstract:BACKGROUND:Internalised stigma is theorized to be the internalisation and legitimisation of stereotypes of the diagnosis held in society and has not been quantified within patients with Rheumatoid Arthritis. This study aimed to: validate a modified version of a measure of internalised stigma, (the Internalised Stigma o...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-016-1089-5

    authors: Corker E,Henderson RC,Lempp H,Brown JS

    更新日期:2016-06-02 00:00:00

  • Illness perceptions in patients receiving rheumatology rehabilitation: association with health and outcomes at 12 months.

    abstract:BACKGROUND:Illness perceptions have been found to change over time and following health care. Hence, addressing illness perceptions alongside existing health care interventions may be important for the sustainment of health gains following rehabilitation. The aim of this study was to measure the illness perceptions of ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2474-14-28

    authors: Løchting I,Fjerstad E,Garratt AM

    更新日期:2013-01-16 00:00:00

  • Classifying health-related quality of life outcomes of total hip arthroplasty.

    abstract:BACKGROUND:Primary total hip arthroplasty (THA) is an effective treatment for hip osteoarthritis, assessed by whatever distribution-based measures of responsiveness. Yet, the group level evaluation has provided very little evidence contributes to our understanding of the large variation of treatment outcome. The object...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-6-48

    authors: Xu M,Garbuz DS,Kuramoto L,Sobolev B

    更新日期:2005-09-06 00:00:00

  • Profiles of responses of immunological factors to different subtypes of Kawasaki disease.

    abstract:BACKGROUND:The responses of immunological factors to different subtypes of Kawasaki disease (KD) remain poorly understood. METHODS:We recruited 388 patients with KD, 160 patients with infectious febrile disease and 85 normal children who served as control subjects. Both the levels and percentages of T lymphocyte subse...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-015-0744-6

    authors: Ding Y,Li G,Xiong LJ,Yin W,Liu J,Liu F,Wang RG,Xia K,Zhang SL,Zhao L

    更新日期:2015-10-23 00:00:00

  • Cumulative occupational lumbar load and lumbar disc disease--results of a German multi-center case-control study (EPILIFT).

    abstract:BACKGROUND:The to date evidence for a dose-response relationship between physical workload and the development of lumbar disc diseases is limited. We therefore investigated the possible etiologic relevance of cumulative occupational lumbar load to lumbar disc diseases in a multi-center case-control study. METHODS:In f...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2474-10-48

    authors: Seidler A,Bergmann A,Jäger M,Ellegast R,Ditchen D,Elsner G,Grifka J,Haerting J,Hofmann F,Linhardt O,Luttmann A,Michaelis M,Petereit-Haack G,Schumann B,Bolm-Audorff U

    更新日期:2009-05-07 00:00:00

  • Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: part II - cervical spine musculature.

    abstract:BACKGROUND:It has been suggested that the quantification of paravertebral muscle composition and morphology (e.g. size/shape/structure) with magnetic resonance imaging (MRI) has diagnostic, prognostic, and therapeutic potential in contributing to overall musculoskeletal health. If this is to be realised, then consensus...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-018-2074-y

    authors: Elliott JM,Cornwall J,Kennedy E,Abbott R,Crawford RJ

    更新日期:2018-05-28 00:00:00

  • Rationale and design of The Delphi Trial--I(RCT)2: international randomized clinical trial of rheumatoid craniocervical treatment, an intervention-prognostic trial comparing 'early' surgery with conservative treatment [ISRCTN65076841].

    abstract:BACKGROUND:Rheumatoid arthritis is a chronic inflammatory disease, which affects 1% of the population. Hands and feet are most commonly involved followed by the cervical spine. The spinal column consists of vertebrae stabilized by an intricate network of ligaments. Especially in the upper cervical spine, rheumatoid art...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-2474-7-14

    authors: Wolfs JF,Peul WC,Boers M,van Tulder MW,Brand R,van Houwelingen HJ,Thomeer RT

    更新日期:2006-02-16 00:00:00

  • A controlled before-after study to evaluate the effect of a clinician led policy to reduce knee arthroscopy in NSW.

    abstract:BACKGROUND:Clinical evidence shows knee arthroscopy has little benefit for degenerative conditions and considerable variation in the incidence of knee arthroscopy in Australia has been identified. This study aimed to evaluate a clinician-led evidence-based policy which was implemented in one local health district in Ne...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-018-2043-5

    authors: Chen HY,Harris IA,Sutherland K,Levesque JF

    更新日期:2018-05-16 00:00:00

  • The efficacy of continuous-flow cryo and cyclic compression therapy after hip fracture surgery on postoperative pain: design of a prospective, open-label, parallel, multicenter, randomized controlled, clinical trial.

    abstract:BACKGROUND:The number of hip fractures and resulting post-surgical outcome are a major public health concern and the incidence is expected to increase significantly. The acute recovery phase after hip fracture surgery in elder patients is often complicated by severe pain, high morphine consumption, perioperative blood ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12891-016-1000-4

    authors: Leegwater NC,Nolte PA,de Korte N,Heetveld MJ,Kalisvaart KJ,Schönhuth CP,Pijnenburg B,Burger BJ,Ponsen KJ,Bloemers FW,Maier AB,van Royen BJ

    更新日期:2016-04-08 00:00:00

  • Value-based cognitive-behavioural therapy for the prevention of chronic whiplash associated disorders: protocol of a randomized controlled trial.

    abstract:BACKGROUND:Whiplash injury is the most common traffic-related injury affecting thousands of people every year. Conservative treatments have not proven effective in preventing persistent symptoms and disability after whiplash injury. Early established maladaptive pain behaviours within the first weeks after the injury m...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12891-015-0687-y

    authors: Andersen TE,Ravn SL,Roessler KK

    更新日期:2015-09-01 00:00:00

  • Satisfaction with care after total hip or knee replacement predicts self-perceived health status after surgery.

    abstract:BACKGROUND:Inpatient satisfaction with care is a standard indicator of the quality of care delivered during hospitalization. Total hip and knee replacement (THR/TKR) for osteoarthritis (OA) are among the most successful orthopaedic interventions having a positive impact on health-related quality of life (HRQoL). The ai...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2474-10-150

    authors: Baumann C,Rat AC,Osnowycz G,Mainard D,Cuny C,Guillemin F

    更新日期:2009-12-03 00:00:00

  • Bone mineral density reference values in Singaporean adults and comparisons for osteoporosis establishment - The Yishun Study.

    abstract:BACKGROUND:While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of oste...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-020-03646-y

    authors: Chen KK,Wee SL,Pang BWJ,Lau LK,Jabbar KA,Seah WT,Srinivasan S,Jagadish MU,Ng TP

    更新日期:2020-09-25 00:00:00

  • Individual and occupational risk factors for knee osteoarthritis - study protocol of a case control study.

    abstract:BACKGROUND:Knee osteoarthritis (OA) is one of the frequent and functionally impairing disorders of the musculoskeletal system. In the literature, a number of occupational risk factors are discussed as being related to the development and progress of knee joint diseases, e.g. working in kneeling or squatting posture, li...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-9-26

    authors: Klussmann A,Gebhardt H,Liebers F,von Engelhardt LV,Dávid A,Bouillon B,Rieger MA

    更新日期:2008-02-26 00:00:00

  • Time taken to resume driving following hip arthroscopy.

    abstract:BACKGROUND:Resuming driving is a common concern among patients undergoing hip arthroscopy. The present study aimed to assess whether patients who had undergone right hip arthroscopy presented with poorer driving performance than patients with normal hips and to analyze the time required to regain preoperative driving p...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-020-03662-y

    authors: Jo S,Lee SH,Jang SW,Choi HB,Kim BR,Jeong JH,Kim SA

    更新日期:2020-09-30 00:00:00

  • Participation in physical activity in patients 1-4 years post total joint replacement in the Dominican Republic.

    abstract:BACKGROUND:To address both the growing burden of joint disease and the gaps in medical access in developing nations, medical relief organizations have begun to launch programs to perform total joint replacement (TJR) on resident populations in developing countries. One outcome of TJR of particular interest is physical ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-15-207

    authors: Elman SA,Dong Y,Stenquist DS,Ghazinouri R,Alcantara L,Collins JE,Beagan C,Thornhill TS,Katz JN

    更新日期:2014-06-16 00:00:00

  • External fixation-assisted reduction for the treatment of neglected hip dislocations with limb length discrepancy: a retrospective study of 13 cases.

    abstract:BACKGROUND:The purpose of this study was to evaluate a new method for treating neglected hip dislocation with limb length discrepancy by using external fixation-assisted pre-reduction. METHODS:Thirteen patients admitted between January 2010 to February 2018 with a mean duration from injury to surgery of 5.0 ± 2.1 mont...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-019-3015-0

    authors: Li P,Tao F,Song W,Dong J,Qiu D,Zhou D

    更新日期:2019-12-26 00:00:00

  • An interdisciplinary clinical practice model for the management of low-back pain in primary care: the CLIP project.

    abstract:BACKGROUND:Low-back pain is responsible for significant disability and costs in industrialized countries. Only a minority of subjects suffering from low-back pain will develop persistent disability. However, this minority is responsible for the majority of costs and has the poorest health outcomes. The objective of the...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-9-54

    authors: Poitras S,Rossignol M,Dionne C,Tousignant M,Truchon M,Arsenault B,Allard P,Coté M,Neveu A

    更新日期:2008-04-21 00:00:00

  • Structured reporting has the potential to reduce reporting times of dual-energy x-ray absorptiometry exams.

    abstract:BACKGROUND:In recent years, structured reporting has been shown to be beneficial with regard to report completeness and clinical decision-making as compared to free-text reports (FTR). However, the impact of structured reporting on reporting efficiency has not been thoroughly evaluted yet. The aim of this study was to ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-020-03200-w

    authors: Kim SH,Sobez LM,Spiro JE,Curta A,Ceelen F,Kampmann E,Goepfert M,Bodensohn R,Meinel FG,Sommer WH,Sommer NN,Galiè F

    更新日期:2020-04-16 00:00:00

  • An investigation of motor learning during side-step cutting: design of a randomised controlled trial.

    abstract:BACKGROUND:Of all athletic knee injuries an anterior cruciate ligament (ACL) rupture results in the longest time loss from sport. Regardless of the therapy chosen, conservative or reconstructive, athletes are often forced to reduce their level of physical activity and their involvement in sport. Moreover, a recent revi...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2474-11-235

    authors: Benjaminse A,Lemmink KA,Diercks RL,Otten B

    更新日期:2010-10-13 00:00:00

  • Unusual localization and presentation of osteoid osteoma mimicking juvenile spondyloarthritis: a case report.

    abstract:BACKGROUND:Osteoid osteoma is a painful benign skeletal tumour of unknown aetiology. Most often it occurs in the long bones of extremities and responds well to nonsteroidal anti-inflammatory medications. However, unusual localization and atypical presentation of this tumour might present a diagnostic challenge, especia...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-018-2383-1

    authors: Vlaic J,Lamot L,Simunic S,Harjacek M,Bojic D

    更新日期:2019-01-08 00:00:00

  • The transition of reported pain in different body regions--a one-year follow-up study.

    abstract:BACKGROUND:The course of pain at a specific region such as the lower back has previously been shown as well as for generalized pain. However we have not found any report on the course of pain from various different specific regions. The aim of this investigation was to study the one-year transition of reported pain in ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-7-17

    authors: Gummesson C,Isacsson SO,Isacsson AH,Andersson HI,Ektor-Andersen J,Ostergren PO,Hanson B,Malmö Shoulder-Neck Study group.

    更新日期:2006-02-23 00:00:00

  • Evidence for validity and reliability of a French version of the FAAM.

    abstract:BACKGROUND:The Foot and Ankle Ability Measure (FAAM) is a self reported questionnaire for patients with foot and ankle disorders available in English, German, and Persian. This study plans to translate the FAAM from English to French (FAAM-F) and assess the validity and reliability of this new version. METHODS:The FAA...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-12-40

    authors: Borloz S,Crevoisier X,Deriaz O,Ballabeni P,Martin RL,Luthi F

    更新日期:2011-02-08 00:00:00

  • Outcome after protected full weightbearing treatment in an orthopedic device in diabetic neuropathic arthropathy (Charcot arthropathy): a comparison of unilaterally and bilaterally affected patients.

    abstract:BACKGROUND:Charcot neuropathic arthropathy (CN) is a chronic, progressive, destructive, non-infectious process that most frequently affects the bone architecture of the foot in patients with sensory neuropathy. We evaluated the outcome of protected weightbearing treatment of CN in unilaterally and bilaterally affected ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-016-1357-4

    authors: Renner N,Wirth SH,Osterhoff G,Böni T,Berli M

    更新日期:2016-12-29 00:00:00

  • PREPARE: Pre-surgery physiotherapy for patients with degenerative lumbar spine disorder: a randomized controlled trial protocol.

    abstract:BACKGROUND:Current guidelines for the management of patients with specific low back pain pathology suggest non-surgical intervention as first-line treatment, but there is insufficient evidence to make recommendations of the content in the non-surgical intervention. Opinions regarding the dose of non-surgical interventi...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12891-016-1126-4

    authors: Lindbäck Y,Tropp H,Enthoven P,Abbott A,Öberg B

    更新日期:2016-07-11 00:00:00

  • Osteochondral autograft transplantation with biplanar distal tibial osteotomy for patients with concomitant large osteochondral lesion of the talus and varus ankle malalignment.

    abstract:BACKGROUND:Osteochondral lesions of the talus (OLTs) are amongst the most common foot and ankle disorders. Varus ankle malalignment causes stress concentration on medial side of the joint, resulting in OLTs and osteoarthritis. For large symptomatic OLTs (>10 mm), Osteochondral autograft transplantation is usually recom...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-016-1367-2

    authors: Li X,Zhu Y,Xu Y,Wang B,Liu J,Xu X

    更新日期:2017-01-19 00:00:00

  • Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage.

    abstract:BACKGROUND:ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stage osteoarthritis. To determine the effect of hemoglobin (Hb) on the ability of synovial tissues to p...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-017-1815-7

    authors: Tajima T,Sekimoto T,Yamaguchi N,Taniguchi N,Kurogi S,Maruyama M,Chosa E

    更新日期:2017-11-14 00:00:00

  • Effects of low-dye taping on plantar pressure pre and post exercise: an exploratory study.

    abstract:BACKGROUND:Low-Dye taping is used for excessive pronation at the subtalar joint of the foot. Previous research has focused on the tape's immediate effect on plantar pressure. Its effectiveness following exercise has not been investigated. Peak plantar pressure distribution provides an indirect representation of subtala...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-10-40

    authors: Nolan D,Kennedy N

    更新日期:2009-04-21 00:00:00

  • The maximal gait speed is a simple and useful prognostic indicator for functional recovery after total hip arthroplasty.

    abstract:PURPOSE:The present study aimed to compare the capabilities of preoperative usual and maximal gait speeds in predicting functional recovery in patients who have undergone total hip arthroplasty (THA). METHODS:Primary and unilateral THAs were performed in 317 patients, and the proportion of patients who achieved unassi...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-020-3093-z

    authors: Shibuya M,Nanri Y,Kamiya K,Fukushima K,Uchiyama K,Takahira N,Takaso M,Fukuda M,Matsunaga A

    更新日期:2020-02-07 00:00:00

  • Trochanteric osteotomy versus posterolateral approach: function the first year post surgery. A pilot study.

    abstract:BACKGROUND:Although no prospective studies have compared functional results of trochanteric osteotomy and a non-trochanteric approach, most surgeons feel that trochanteric osteotomy is outdated in simple hip arthroplasty. Reasons not to perform an osteotomy include the fear of longer rehabilitation and worse (final) fu...

    journal_title:BMC musculoskeletal disorders

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2474-12-138

    authors: van der Grinten M,Reijman M,van Biezen FC,Verhaar JA

    更新日期:2011-06-26 00:00:00

  • The Key Indicator Method for Manual Handling Operations (KIM-MHO) - evaluation of a new method for the assessment of working conditions within a cross-sectional study.

    abstract:BACKGROUND:Upper extremity musculoskeletal symptoms and disorders are common in the working population. The economic and social impact of such disorders is considerable. Long-time, dynamic repetitive exposure of the hand-arm system during manual handling operations (MHO) alone or in combination with static and postural...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-11-272

    authors: Klussmann A,Steinberg U,Liebers F,Gebhardt H,Rieger MA

    更新日期:2010-11-25 00:00:00