Methylene blue: an effective treatment for contrast medium-induced anaphylaxis.

Abstract:

BACKGROUND:The purpose of this paper is to propose methylene blue as a lifesaving alternative drug for the treatment of contrast-induced anaphylaxis. CASE REPORT:In a cardiovascular catheterization laboratory invasive hemodynamic monitoring was used to document the lifesaving effect of IV bolus injections of 1.5-2 mg/Kg methylene blue solution to treat three patients for anaphylactic shock following radiocontrast injection during coronary angiography. Methylene blue administration was followed by prompt circulatory improvement, leading to hemodynamic stabilization and relief of other anaphylactic symptoms in each case. There were no deaths. CONCLUSIONS:Our findings suggest that methylene blue can be lifesaving in anaphylactic shock, notwithstanding some transitory side effects, such as cardiac rhythm disturbances and chest pain, both of which possibly originate from sudden myocardial perfusion deficits.

journal_name

Med Sci Monit

authors

Oliveira Neto AM,Duarte NM,Vicente WV,Viaro F,Evora PR

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

CS102-6

issue

11

eissn

1234-1010

issn

1643-3750

pii

3671

journal_volume

9

pub_type

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