Extraprostatic complications of testosterone replacement therapy.

abstract：:The long arm of the Y chromosome contains genes mapped in loci involved in male infertility, short stature and gonadoblastoma. However, many of these genes have not been fully characterized, and are not currently investigated in patients affected by such diseases. We report a study aimed to the genomic characterizatio...

journal_title：Journal of endocrinological investigation

authors： Stuppia L,Gatta V,Fogh I,Gaspari AR,Grande R,Morizio E,Fantasia D,Pizzuti A,Calabrese G,Palka G

更新日期：2000-11-01 00:00:00

abstract：:Fifty-seven (35.6%) of 160 patients with papillary thyroid carcinoma had lymph node metastases at the primary treatment. Children and adolescents were most frequently affected (69.2%), followed by the age group of 21-40-year olds (38.8%). Those older than 40 had the lowest incidence of lymph node metastases (29.6%; p ...

journal_title：Journal of endocrinological investigation

authors： Ahuja S,Ernst H,Lenz K

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Studies from every continent have shown that only around 50% of the patients subjected to thyroid hormone replacement have TSH in the normal range. However, to date, there are no consistent data about Brazil. OBJECTIVES:To evaluate levothyroxine (LT4) replacement treatment in patients with primary hypothyro...

journal_title：Journal of endocrinological investigation

authors： Vaisman F,Coeli CM,Ward LS,Graf H,Carvalho G,Montenegro R Jr,Vaisman M

更新日期：2013-07-01 00:00:00

abstract：:Entering puberty is one of the most important milestones in life. Studies from around the world have shown that age of pubertal changes onset can vary with race and ethnicity, environmental conditions, geographical location and nutrition. In the last century, the onset of puberty progressively shifted back towards you...

journal_title：Journal of endocrinological investigation

authors： Castellino N,Bellone S,Rapa A,Vercellotti A,Binotti M,Petri A,Bona G

更新日期：2005-07-01 00:00:00

abstract：:The mechanisms underlying the antifertility effects of hyperprolactinemia have yet to be established in an appropriate experimental model. Hyperprolactinemia is a known side effect of fluphenazine, a broad spectrum, long-acting phenothiazine known to be dopamine type-D2 receptor antagonist. In our earlier study in adu...

journal_title：Journal of endocrinological investigation

authors： Aleem M,Choudhari J,Padwal V,Balasinor N,Parte P,Gill-Sharma MK

更新日期：2005-01-01 00:00:00

abstract：:Recent evidence suggests that patients with traumatic brain injury (TBI) are at substantial risk of hypopituitarism. The pathomechanisms, however, are not completely understood yet. Little is known about the association of morphological changes in the sella region with pituitary function in TBI. In this study, we asse...

journal_title：Journal of endocrinological investigation

authors： Schneider HJ,Sämann PG,Schneider M,Croce CG,Corneli G,Sievers C,Ghigo E,Stalla GK,Aimaretti G

更新日期：2007-04-01 00:00:00

abstract：:Recently, highly purified bovine thyrotropin (bTSH) of pituitary origin, as well as recombinant human (h) TSH free of lutropin (LH) contamination, has been reported to activate the LH/choriogonadotropin receptor (LH/CGR). These data challenge the concept of TSH specificity for its own receptor. We, therefore, re-evalu...

journal_title：Journal of endocrinological investigation

authors： Nagayama Y,Yamasaki H,Takeshita A,Kimura H,Ashizawa K,Yokoyama N,Yamashita S,Rapoport B,Nagataki S

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Adipose tissue has been suggested to influence bone density and metabolism through the effect of some adipokines. However, whether adiponectin and visfatin may correlate with bone metabolism is still unclear. AIM:The aim of this study was to investigate the relationship of adiponectin and visfatin with bone...

journal_title：Journal of endocrinological investigation

authors： Iacobellis G,Iorio M,Napoli N,Cotesta D,Zinnamosca L,Marinelli C,Petramala L,Minisola S,D'Erasmo E,Letizia C

更新日期：2011-01-01 00:00:00

abstract：:Pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) are two cross-links of collagen molecules, that are present in the extracellular matrix and released during its degradation. Pyr is present in bone and cartilage, but not in significant amounts in other connective tissues and D-Pyr appears to be specific for bone tissue...

journal_title：Journal of endocrinological investigation

authors： Calabresi E,Lasagni L,Franceschelli F,de Leonardis V,Becorpi A,Serio M,Brandi ML

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To assess the relationship of waist circumference and weight/height ratio with height, and their association with components of the metabolic syndrome, in Type 2 diabetic patients. DESIGN:multicenter cross-sectional survey on a cohort enrolled in a prospective observational study. SUBJECTS:13,232 patients (...

journal_title：Journal of endocrinological investigation

authors： Mannucci E,Alegiani SS,Monami M,Sarli E,Avogaro A,DAI (Diabetes and Informatics) Study Group.

更新日期：2004-06-01 00:00:00

abstract：:Steroid 21-hydroxylase deficiency (21OHD) compromises about 95% of all cases of congenital adrenal hyperplasia. We have characterized the disease-causing mutations in the steroid 21-hydroxylase genes of 19 Chilean patients (12 females and 7 males) with the simple virilizing (SV) form of 21OHD and compared them with ot...

journal_title：Journal of endocrinological investigation

authors： Fardella CE,Poggi H,Soto J,Torrealba I,Cattani A,Ugarte F,Cortinez A,Foradori A

更新日期：2000-06-01 00:00:00

abstract：:We examined the distribution of nuclear T3 in mature rat brain with the aim of determining specific targets of thyroid hormones within this tissue. Saturation experiments, performed in 9 different structures of the brain and in 4 parts of the cortex, revealed the presence of a single class of binding sites with a mean...

journal_title：Journal of endocrinological investigation

authors： Ruel J,Faure R,Dussault JH

更新日期：1985-08-01 00:00:00

abstract：:Endocrine changes have been reported in treated epileptic subjects, who often exhibit sexual dysfunctions, but the endocrine effects of single antiepileptic drugs have not been completely elucidated. In this study we have investigated the influence of phenobarbital (PB) on adenopituitary function and on peripheral sex...

journal_title：Journal of endocrinological investigation

authors： Murialdo G,Manni R,De Maria A,Bonura ML,Polleri A,Tartara A

更新日期：1987-02-01 00:00:00

abstract：:Gonadotropins control male and female gonadal function by acting through specific receptors. The recent description of several mutations in LH and FSH receptors has significantly improved our understanding of the pathophysiology of several sexual disorder. Both gain- and loss-of-function germline mutations leading to ...

journal_title：Journal of endocrinological investigation

authors： Beck-Peccoz P,Romoli R,Persani L

更新日期：2000-10-01 00:00:00

abstract：:17alpha-hydroxylase deficiency (17alpha-OHDS) results in decreased production of cortisol and sex steroids and hypokalemia secondary to excess mineralocorticoids. It has long been known that glucocorticoid deficiency is associated with impaired urinary dilution and increased secretion of vasopressin (AVP). On the othe...

journal_title：Journal of endocrinological investigation

authors： Leal AM,Elias PC,Moreira AC

更新日期：2002-07-01 00:00:00

abstract：:Short stature homeobox-containing (SHOX) gene mutations causing haploinsufficiency have been reported in idiopathic short stature, but the real prevalence of this defect in the population with growth failure is debated. Based on current data, the prevalence of SHOXdefect (SHOX-D) has been calculated to have occurred i...

journal_title：Journal of endocrinological investigation

authors： Cicognani A,Pirazzoli P,Nicoletti A,Baronio F,Conti V,Bonetti S

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Focal thyroid incidentaloma (TI) occurs in a 2% of 18F-FDG PET/CT and about one-third of TIs is cancer. Due to the lack of evidence on the optimal management of TI, current guidelines suggest performing fine-needle aspiration cytology (FNA). The study aim was to evaluate the reliability of ACR-TIRADS, EU-TIRA...

journal_title：Journal of endocrinological investigation

authors： Trimboli P,Knappe L,Treglia G,Ruberto T,Piccardo A,Ceriani L,Paone G,Giovanella L

更新日期：2020-11-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to re...

journal_title：Journal of endocrinological investigation

authors： Boland JM,Tebben PJ,Folpe AL

更新日期：2018-10-01 00:00:00

abstract：:We evaluated the oral calcium-loading test (OCLT) in diagnosing normocalcemic primary hyperparathyroidism. Calcium and PTH levels were measured before, 60, 120 and 180 min after oral 1 g of calcium gluconolactate administration in 102 consecutive females with high circulating PTH levels, and 25 controls. Patients were...

journal_title：Journal of endocrinological investigation

authors： Hagag P,Revet-Zak I,Hod N,Horne T,Rapoport MJ,Weiss M

更新日期：2003-04-01 00:00:00

abstract：:The occurrence of metabolic bone disease in patients with renal dysfunction is due to the key role played by the kidney in regulating calcium-phosphate metabolism. The incidence of hip fractures in end-stage renal disease is 3- to 4-fold higher than the general population, while poor data about vertebral fractures sho...

journal_title：Journal of endocrinological investigation

authors： Fusaro M,D'Angelo A,Scalzo G,Gallieni M,Giannini S,Guglielmi G

更新日期：2010-05-01 00:00:00

abstract：:EP1572 UMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after s.c. administration in neonatal rats. Preliminary data in 2 normal young men s...

journal_title：Journal of endocrinological investigation

authors： Broglio F,Boutignon F,Benso A,Gottero C,Prodam F,Arvat E,Ghè C,Catapano F,Torsello A,Locatelli V,Muccioli G,Boeglin D,Guerlavais V,Fehrentz JA,Martinez J,Ghigo E,Deghenghi R

更新日期：2002-09-01 00:00:00

abstract：:As it has been hypothesized that IGF-binding proteins (IGFBPs) may have a role as autocrine/paracrine factors in regulating the local actions of the insulin-like growth factors (IGFs) in the ovary, we studied the production of the IGFBPs by human granulosa cells (GC) in culture and the role of IGFBP-3 in the modulatio...

journal_title：Journal of endocrinological investigation

authors： Barreca A,Artini PG,Cesarone A,Arvigo M,D'Ambrogio G,Genazzani AR,Giordano G,Minuto F

更新日期：1996-01-01 00:00:00

abstract：:The effects of short term administration of 200 MRC U of synthetic salmon calcitonin (sCT) daily on carbohydrate metabolism were investigated in 10 patients with various bone diseases, 3 of whom had type II diabetes mellitus and 3 of whom had impaired glucose tolerance. Blood glucose levels during the nocturnal postab...

journal_title：Journal of endocrinological investigation

authors： Giustina G,Cerudelli B,Cimino A,Rigosa C,Rotondi A,Radaeli E

更新日期：1985-02-01 00:00:00

abstract：:The authors report the profiles of luteinizing hormone (LH), estradiol (E2), progesterone (P) and androstenedione (A) in some female pigs with altered plasma hormonal levels. Twenty cycles are described and 19 out of them are characterized by low plasma P in luteal phase of different etiology, at least as measured by ...

journal_title：Journal of endocrinological investigation

authors： Pierantoni R,Genazzani AR,Perotti L,Enne G,Inaudi P,d'Istria M,Musarò MA,Citarella F,Fasano S,Delrio G

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine whether the triglycerides and glucose (TyG) index is associated with the presence of metabolically obese normal-weight (MONW) phenotype and related cardiovascular risk factors. METHODS:Apparently healthy men and non-pregnant women aged 20-65 years were enrolled in a popul...

journal_title：Journal of endocrinological investigation

authors： Morales-Gurrola G,Simental-Mendía LE,Castellanos-Juárez FX,Salas-Pacheco JM,Guerrero-Romero F

更新日期：2020-07-01 00:00:00

abstract：:Thyrocytes from normal and goitrous portions of the thyroid gland from a patient with an enormous (635 gm) goiter were cultured in media, and their relative abilities to uptake thymidine, synthesize DNA, and secrete Tg and T4 were assessed. Tg, T4 and the ratio Tg/T4 in media at 72 h were 120 micrograms/dl, 1.6 microg...

journal_title：Journal of endocrinological investigation

authors： Tseng YC,Burman KD,Baker JR Jr,D'Avis J,Wartofsky L

更新日期：1987-10-01 00:00:00

abstract：:An immunohistochemical study with two rabbit polyclonal antibodies I-AR76 and CA-08-351 against Endothelin-1 (ET-1) was performed in 133 human thyroid specimens: 5 normal thyroids, 30 multinodular goiters (15 toxic and 15 nontoxic), 20 Graves' diseases, 5 Hashimoto's thyroiditis, 26 adenomas (6 Hürthle cell, 16 toxic ...

journal_title：Journal of endocrinological investigation

authors： Lenziardi M,Viacava P,Fiorini I,Castagna M,Nardini V,Pollina L,De Negri F,Goletti O,Di Coscio G,Bevilacqua G

更新日期：1995-05-01 00:00:00

abstract：:A dialyzable, thermostable inhibitor of normal thyroid peroxidase (TPO), with UV absorption maximum at 250-260 nm, was found in the digitonized, washed particulate fraction of two dyshormonogenetic goiters. No intrinsic TPO iodide-oxidation activity was detectable in either of these goiters, and their TPO iodination a...

journal_title：Journal of endocrinological investigation

authors： Rosenthal D,Carvalho-Guimarães DP,Knobel M,Medeiros-Neto GA

更新日期：1990-12-01 00:00:00

abstract：:Reportedly, the responsiveness of somatotrope cells to GHRH is reduced in elderly humans but it is totally restored by arginine (ARG) which likely acts by inhibiting hypothalamic release of somatostatin. As this effect was observed after infusion of high doses of the amino acid, in this study, we compared the effect o...

journal_title：Journal of endocrinological investigation

authors： Ghigo E,Ceda GP,Valcavi R,Goffi S,Zini M,Mucci M,Valenti G,Cocchi D,Müller EE,Camanni F

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A v...

journal_title：Journal of endocrinological investigation

authors： Kim SY,Lim JH,Yang JH,Kim MY,Kim MH,Park SY,Ryu HM

更新日期：2008-08-01 00:00:00