Abstract:
:To clarify the effect of CTLA4-lg on immune rejection of bone grafts, we observed the effect of CTLA4-lg on lymphocyte proliferation of BALB/C mice stimulated by lymphocytes and bone supernatant of C57BL/6 mice. The splenic lymphocytes and bone supernatant of C57BL/6 mice, as the stimulator cells and stimulator antigens, were cultured in vitro with the splenic lymphocyte of BALB/C mice. At the same time, CTLA4-lg at a dose of 5,10 or 20 &mgr;g/ml and L6 (as control) at 20 &mgr;g/ml were added. Six days later, the incorporation of 3 H-TdR was determined. Results indicated that CTLA4-Ig at a dose of 5, 10 or 20 &mgr;g/ml significantly inhibited the cell proliferation stimulated by lymphocytes and bone supernatant of C57BL/6 mice. The effect was non-cytotoxic. L6 showed no significant inhibition of cell proliferation. CTLA4-Ig can efficiently block the proliferation of alloresponsive T cell stimulated by lymphocytes and bone supernatant of C57BL/6 mice. This study provides a basis for further study of CTLA4-induced immune tolerance of bone grafts.
journal_name
J Orthop Surg (Hong Kong)journal_title
Journal of orthopaedic surgery (Hong Kong)authors
Guo C,Dai K,Tang Tdoi
10.1177/230949900000800114subject
Has Abstractpub_date
2000-06-01 00:00:00pages
79-82issue
1eissn
1022-5536issn
2309-4990journal_volume
8pub_type
杂志文章abstract:PURPOSE:To study the course of L4 to S3 nerve roots and their distance with the ala of the sacrum and the sacroiliac joint. METHODS:The embalmed left half pelvis of 25 male and 27 female cadavers aged 30 to 91 (mean, 68) years were studied. The ventral rami of the L4, L5, S1, S2, and S3 nerve roots were dissected alon...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901001800319
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Juvenile hallux valgus (JHV) frequently results in an impaired quality of life because of pain and deformity. We used a validated clinical score to investigate the efficacy of lateral hemiepiphysiodesis of the first metatarsal base as a treatment for JHV. METHODS:We conducted a prospective, nonrandomized, s...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 临床试验,杂志文章
doi:10.1177/2309499018801135
更新日期:2018-05-01 00:00:00
abstract::Tumours and metastases of the spine are extremely stressful for patients, especially for elderly multimorbid patients. The modern cavity/coblation method offers a very good therapeutic alternative for such patients. The goal of this article was to evaluate and present the characteristics, significance, opportunities, ...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499016684505
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To report the radiological and clinical results of revision total hip arthroplasty (THA) with femoral impaction bone grafting (IBG). METHODS:4 men and 9 women (15 hips) aged 38 to 84 years underwent revision THA with femoral IBG using Elite plus stems for aseptic loosening or infection. RESULTS:The mean follo...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901001800309
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:Reconstruction of the anterior cruciate ligament (ACL) is the most frequently performed reconstructive surgery in the knee. Biomechanical studies have shown that double bundle (DB) reconstruction is better than single bundle (SB) reconstruction with regard to rotational stability. It is postulated that resectio...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499018773124
更新日期:2018-05-01 00:00:00
abstract::We report on a 17-year-old man who underwent open reduction and internal fixation for an inferior dislocation of the right hip and displaced fractures of the right femoral head and neck, and antegrade intramedullary nailing for a displaced fracture of the left femoral shaft. In addition, 13 men and 4 women aged 5 to 5...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章,评审
doi:10.1177/230949901502300128
更新日期:2015-04-01 00:00:00
abstract::Concomitant fungal and bacterial atlanto-axial osteomyelitis in immunocompetent individuals is rare. We report one such patient who underwent transoral anterior decompression and posterior occipital cervical fusion, together with antibiotic and antifungal treatment. At 16-month follow-up, the patient had made a full r...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901001800221
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:To assess the criterion validity, repeatability, and the missing value protocol of the reduced Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function scale ('reduced scale'). METHODS:Three separate studies were performed: a cross-over study to compare the full- and reduced-scale scores...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900801600113
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:To evaluate the role of sympathetic skin response (SSR) and three-phase bone scintigraphy (TPBS) in the diagnosis of complex regional pain syndrome (CRPS). METHODS:60 patients with CRPS of the hand were recruited. TPBS was performed using a bolus injection of 20 mCi of Tc-99m methylene diphosphonate in an ante...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900601400310
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:Fingertip replantation is a challenging and technically demanding procedure. A variety of venous drainage techniques have been attempted for successful fingertip replantation. We present a new venous drainage technique, known as serial multifocal incision for fingertip replantation. METHODS:Between 2006 and 20...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019831480
更新日期:2019-01-01 00:00:00
abstract::Cervical cancer patients may experience hip problems related to the cancer itself or therapeutic management for the cancer. Septic arthritis should be one of the possibilities but there have been no reports on this. Here we present three patients who developed hip problems more than two years after radiotherapy with o...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900100900209
更新日期:2001-12-01 00:00:00
abstract::Cervical endoscopic spinal surgery (CESS) is now regularly performed in some centres in the Far East, yet rarely in Europe and the United States. This review describes the application of CESS through anterior and posterior approaches with analysis of the available evidence supporting current techniques. An electronic ...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章,评审
doi:10.1177/2309499018758520
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Various radiographic measurements that describe humeral head coverage by the acromion and the effect on rotator cuff pathology have been reported. This study aimed to describe and validate a new radiographic measurement, the acromiohumeral centre edge angle (ACEA). METHODS:We compared the ACEA on computed t...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499017727950
更新日期:2017-09-01 00:00:00
abstract::A subcapital femoral neck fracture complicating a healed trochanteric fracture is rare. Such cases are managed in a rather heterogeneous manner, i.e. there exists a mixture of cases treated by either fixed angle devices or dynamic compression screws. We describe 5 patients who developed subcapital femoral neck fractur...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900701500224
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Trigger finger release utilizing wide-awake local anesthesia no tourniquet (WALANT) usage in extremity surgery is not widely used in our setting due to the possibility of necrosis. Usage of a tourniquet is generally acceptable for providing surgical field hemostasis. We evaluate hemostasis score, surgical fi...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章,随机对照试验
doi:10.1177/2309499019833002
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Various modes of therapy have been directed at breaking the vicious cycle at early stage of synovitis in haemophilia patients. This study was planned to assess the short-term clinico-radiological outcome of chronic knee synovitis among haemophilia A patients post phosphorus-32 (P-32) radiosynoviorthesis. METHO...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499016684500
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Osteochondral impaction grafting to manage isolated chondral defects in femoral condyles usually uses a metal punch to impact the grafts into predrilled cavities. Damage to the chondrocytes during impaction is a concern, however, and new methods are being sought to minimise the damage. We studied if impaction w...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900201000211
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:We have analyzed the surgical outcomes of primary total knee arthroplasty (TKA) using computer-assisted (CA) navigation in terms of postoperative coronal alignment depending on preoperative lateral femoral bowing. METHODS:We conducted a retrospective study of patients who have undergone navigated primary TKA f...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499020965679
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:This study assessed the levels of soluble tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and matrix metalloproteinase 1 (MMP-1) in the synovial fluid from osteoarthritic knees to determine their role as well as the relationship between these levels and the severity of osteoarthritis (OA). METHODS...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499018760112
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Navigation is associated with improved accuracy in alignment. However, its influence on clinical outcome is inconclusive. The aim of this study was to compare the component alignment and functional outcome in patients undergoing navigation-assisted and conventional total knee replacement (TKR). MATERIALS AN...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019848079
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To compare the analgesic effect of preoperative ropivacaine with or without tramadol for femoral nerve block in total knee arthroplasty (TKA). METHODS:14 men and 46 women aged 59 to 80 years who were American Society of Anesthesiologists (ASA) grade I or II and were scheduled for TKA were randomised to receive...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章,随机对照试验
doi:10.1177/1602400213
更新日期:2016-08-01 00:00:00
abstract:INTRODUCTION:The effect of leg dominance on anterior cruciate ligament (ACL) injuries has been studied with some studies noting a propensity for injuries in the non-dominant leg. Its effect on post-ACL reconstruction recovery, however, is not well known. The authors hypothesize that dominant limb injuries undergo rehab...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019896232
更新日期:2020-01-01 00:00:00
abstract::One hundred and sixty-six cementless primary total hip arthroplasties were performed in 133 patients with porous coated Omnifit prosthesis. The average age was 49.7 years. The mean follow-up period was 8.2 years with a minimum of 5 years. Good to excellent clinical results were achieved in 93% of patients. The overall...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900000800209
更新日期:2000-12-01 00:00:00
abstract::We describe a modified surgical technique developed to enhance the classical irrigation and debridement procedure to improve the possibilities of retaining an infected total knee arthroplasty. This technique, debridement antibiotic pearls and retention of the implant (DAPRI), aims to remove the intra-articular biofilm...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019874413
更新日期:2019-09-01 00:00:00
abstract::Acetabular wedge augmentation is a useful technique and is recommended in situations where cup revision is likely to be excessively difficult. Numerous augmentation designs that improve the stability of the hip are now available in the market. Occasionally, however, these devices are not readily available, particularl...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900501300221
更新日期:2005-08-01 00:00:00
abstract::Resection and reconstruction using a vascularised fibular graft is a viable alternative treatment for congenital pseudarthrosis of the tibia, although distal junctional nonunion and residual deformity are known complications that are difficult to treat. We illustrate 2 cases in which bony union was achieved following ...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900601400114
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:To review nutritional status and outcome of 90 patients who underwent total hip arthroplasty (THA) or hemiarthroplasty. METHODS:Records of 51 women and 39 men aged 26 to 96 (median, 71) years who underwent elective THA (n=48) for osteoarthritis, or trauma-related THA (n=10) or hemiarthroplasty (n=32) for subca...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901202000313
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To assess the prevalence of proximal high-origin anterior tibial artery and its surgical significance. METHODS:100 knees were prospectively studied using colour Doppler ultrasonography. No patient had a history of lower-limb arterial pathology or previous knee surgery. All ultrasound images were assessed by a ...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900601400104
更新日期:2006-04-01 00:00:00
abstract:INTRODUCTION:Hyalofast grafting with microfracture is a new minimally invasive treatment method being proposed for joint cartilage defects. This study was done to measure the clinical efficacy of Hyalofast grafting after microfractures. METHODS:Forty-six patients were assessed for knee function using knee injury and o...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499020905158
更新日期:2020-01-01 00:00:00
abstract::We report on a 30-year-old haemophilic man with a pelvic pseudotumour compressing adjacent structures causing pain and swelling and destruction of surrounding soft tissues and bones. He underwent evacuation of the pseudotumour, acetabular reconstruction using the Harrington procedure, and total hip arthroplasty. ...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901402200232
更新日期:2014-08-01 00:00:00