Abstract：
:A 41-year-old white homosexual man presented with epigastric pain and jaundice. Physical examination showed enlargement of bilateral axillar and left inguinal lymph node, while ERCP and a CT scan suggested interruption of bile flow in the intrapancreatic tract of the common bile duct. An endoprosthesis was positioned in the common bile duct during the ERCP. Blood tests (both ELISA and Western blot techniques) showed positivity for anti-HIV antibodies and a CD4 count of 780/mmc (normal: 900-1,200/mmc). A few days later, a dramatic increase of the size of a lymph node in this right axilla occurred, rapidly reaching 5 cm of diameter. A biopsy was performed at this level, and histological examination revealed a high grade B-cell Burkitt type lymphoma. Bone marrow biopsy was negative, as well as lumbar puncture. Aggressive chemotherapy with adriamycin, cyclophosphamide, bleomycine, eldesine and prednisone, together with intratechal administration of methotrexate, was attempted. However, after a marginal and transient regression, the NHL rapidly progressed and the patient eventually died seven months after the diagnosis of NHL. A post mortem examination confirmed the diagnosis of Burkitt lymphoma of the peripancreatic and axillar lymph nodes, with diffusion to the leptomeninges, subaracnoideal spaces and encephalus. No signs of lymphoma were detected in other nodal or extra nodal areas.
journal_name
J Exp Clin Cancer Resjournal_title
Journal of experimental & clinical cancer research : CRauthors
De Toma G,Codacci-Pisanelli M,Nicolanti V,Plocco M,Caterino S,Perno CFkeywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
459-62issue
4eissn
0392-9078issn
1756-9966journal_volume
18pub_type
杂志文章abstract：BACKGROUND:Kidney Renal Clear Cell Carcinoma (KIRC) accounts for 75% of all renal cancers. Previous study had conflict evidences regarding NR1B2 role in cancer, and its expression and biological role in KIRC remained unclear. Our aims were to characterize the role of NR1B2 in KIRC. METHODS:NR1B2 expression in TCGA dat...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1344-3
更新日期：2019-08-07 00:00:00
abstract：:The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results were inconclusive and controversial. Our aim of this study was to evaluate this association by literature base...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1756-9966-32-15
更新日期：2013-03-15 00:00:00
abstract：BACKGROUND:Hepatoblastoma (HB) is a common liver malignancy in children. Our previous study has disclosed the crucial role of STAT3 (signal transducer and activator of transcription 3) in HB. AIM OF THE STUDY:Present study was designed to study the circular RNA (circRNA) STAT3 in HB. METHODS:Gel electrophoresis revea...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-020-01598-8
更新日期：2020-06-03 00:00:00
abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due to the paucity of effective targeted therapy. ESCC is believed to arise from cancer stem cells (CSCs) that contribute to metastasis and chemoresistance. Despite advances in diagnosis and treatment, the p...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1296-7
更新日期：2019-07-11 00:00:00
abstract：:Doxorubicin (DOX) has a wide spectrum of antitumor activity with dose-related cardiotoxicity as a major side effect. This cardiotoxicity has been suggested to result from the generation of oxygen-free radicals. The objective of the present study was to investigate the influence of the antioxidant, thymoquinone (TQ) on...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients that carry alterations in homologous DNA repair genes, letting to envisage susceptibility to the Po...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/s13046-019-1089-z
更新日期：2019-02-22 00:00:00
abstract：:Gastric cancer, characterized by poor prognosis, remains a global health problem. Thus, it is important to describe the biological factors which can affect the prognosis in this disorder. The aim of our study was the determination of the relationship between apoptotic index (AI) and other clinicopathological features ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:This study was undertaken in order to verify if peri-operative serum lactate level changes, resulting from manipulation of the splanchnic circulation during pancreatectomy, reflected clinical outcome in twenty patients (9 males-11 females age 33 to 76) operated for pancreatic cancer. Lactate levels were evaluated at t...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. METHODS:Immunohistochemistry was used to investigate Kindlin-2 expression in 177 pai...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-017-0603-4
更新日期：2017-09-29 00:00:00
abstract：:Horseshoe kidney is a congenital anomaly of the upper urinary system frequently associated with atypical vascularization, mostly asymptomatic, usually undetected until the onset of infectious, obstructive or neoplastic complications. Although intravenous pyelography and US are useful tools, the role of CT is of vital ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:Several targeted immunotherapies have recently showed significant advances in treatment of non-small cell lung cancer (NSCLC), including antibodies and inhibitors targeting programmed death-1 (PD-1) and its ligand (PD-L1). METHODS:Tumor tissue samples were prospectively collected from 183 patients with NSCL...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1192-1
更新日期：2019-05-14 00:00:00
abstract：BACKGROUND:m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process has been found to be upregulated in many cancers, including CRC. Here, we investigate m6A modification and the underlying mechanism of METTL3 in the developmen...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1408-4
更新日期：2019-09-06 00:00:00
abstract：:Glioblastoma multiform (GBM) is the most common tumour of the central nervous system in humans. Unfortunately its prognosis is poor and because of the lack of efficacious therapies, immunotherapy is a potential treatment. Transfer factors (TF) are low molecular weight dialysable products extracted from immune cells wh...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2005-12-01 00:00:00
abstract：:The immune system in patients detects and eliminates tumor cells, but tumors still progress persistently. The mechanisms by which tumor cells survive under the pressure of immune surveillance are not fully understood. This review is to present the evidence from clinical studies, showing a significant correlation of cl...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/1756-9966-30-12
更新日期：2011-01-21 00:00:00
abstract：:The renal oncocytoma is a solid epithelial neoplasm with a generally benign course. The improved image diagnostics with the computerized tomography (CT) and magnetic resonance imaging (MRI) should today permit the identification of these lesions preoperatively so that conservative rather than radical surgery can be em...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive. METHODS:We performed a transcriptome-wide screen to ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-0840-1
更新日期：2018-08-07 00:00:00
abstract：:RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy receptor osteoprotegerin (OPG). Although this system is critical for the regulation of osteoclast differentia...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/s13046-018-1001-2
更新日期：2019-01-08 00:00:00
abstract：BACKGROUND:Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molecular mechanism. METHODS:The changes of macrophage phenotypes after P...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-020-01786-6
更新日期：2021-01-04 00:00:00
abstract：:The aim of the present study was to assess the role of virtual cystoscopy in the identification of bladder tumors. Fifteen patients (11 men and 4 women, median age: 61 years, range: 46-74 years) with a positive finding of bladder tumor at fiber-optic cystoscopy were studied by multislice-CT. Scans were downloaded to a...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:Colon cancer represents one of the leading causes of gastrointestinal tumors in industrialized countries, and its incidence appears to be increasing at an alarming rate. Accumulating evidence has unveiled the contributory roles of cancer stem cells (CSCs) in tumorigenicity, recurrence, and metastases. The fu...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-020-01704-w
更新日期：2020-10-28 00:00:00
abstract：:Axillary lymphadenectomy is a very important procedure in the staging of breast cancer patients. However, it is associated with a significant morbidity rate. On the other hand, using early diagnosis we can see a high number of cases where the lymph nodes are negatives. With the intention of avoiding unnecessary axilla...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:Colorectal cancer is the third most commonly diagnosed cancer worldwide. Although surgery remains the best treatment for this disease, adjuvant chemotherapy and radiotherapy are also very important in clinical practice. However, the notorious refractory lack of responses to radiochemotherapy greatly limits the applica...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-33-13
更新日期：2014-01-29 00:00:00
abstract：:Intraoperative radiotherapy with a single dose of electrons (ELIOT) in the conservative treatment of breast cancer is a possibility under evaluation in clinical trials. The costs of the mobile linear accelerator with a robotic arm, used in intraoperative radiotherapy, are prohibitive for poor countries. The aim of thi...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Pancreatic ductal adenocarcinoma is one of the leading causes of cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, is a new therapeutic strategy for cancer treatment but the monotherapy with PD-L1 inhibitors for pancreatic cancer is almost ineffective for...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1044-z
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:New chemotherapic agents and new protocols in oncology have led to an increasing survival rate in patients affected by tumors. However, this increased use has been accompanied by a growth in the incidence of cutaneous side effects and a worsening of patients' quality of life. Appropriate management of skin t...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-31-50
更新日期：2012-05-28 00:00:00
abstract：:Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle therapeutics that target the cyclin D-CDK4/6 complex and induce G1 phase arrest. These agents have demonstrated...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/s13046-020-01693-w
更新日期：2020-09-15 00:00:00
abstract：BACKGROUND:Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in many carcinoma types, but its role in head and neck squamous cell carcinoma (HNSCC) is unclear. Our aim was to clarify whether mRNA expression of EGFR-ligands was linked to...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-016-0422-z
更新日期：2016-09-26 00:00:00
abstract：BACKGROUND:The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tumor progression remain...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-0701-y
更新日期：2018-02-26 00:00:00
abstract：:The authors report one case of cauda equina paraganglioma and review the neurosurgical, radiological and pathological literatureon this rare tumour. Although it is difficult to distinguish preoperatively the paraganglioma from other tumours of the cauda equina, like neurinoma or ependymoma, this neuroendocrine tumour ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:The efficacy of currently developed methods for gene transfer into mammalian cells depends primarily on the transfection technique, and also on the type of targeted cells. Considering the importance of gene transfer in the creation of gene therapies, our study was aimed at the assessment of transfection capacity of re...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
