Pyridoxine (vitamin B6) supplementation in pregnancy.


BACKGROUND:Vitamin B6 plays vital roles in numerous metabolic processes in the human body, such as nervous system development and functioning. It has been associated with some benefits in non-randomised studies, such as higher Apgar scores, higher birthweights, and reduced incidence of pre-eclampsia and preterm birth. Recent studies also suggest a protection against certain congenital malformations. OBJECTIVES:To evaluate the clinical effects of vitamin B6 supplementation during pregnancy and/or labour. SEARCH STRATEGY:We searched the Cochrane Pregnancy and Childbirth Group Trials Register (30 December 2005). SELECTION CRITERIA:We included randomised controlled trials comparing vitamin B6 administration in pregnancy and/or labour with: placebos, no supplementations, or supplements not containing vitamin B6. DATA COLLECTION AND ANALYSIS:Two authors independently extracted data and assessed trials for methodological quality. We used relative risk and weighted mean difference with 95% confidence intervals. MAIN RESULTS:Five trials (1646 women) were included. Four trials used blinding. One had adequate method of randomisation and allocation concealment; four did not report this. Three trials had large losses to follow up. Vitamin B6 as oral capsules or lozenges resulted in decreased risk of dental decay in pregnant women (capsules: relative risk (RR) 0.84; 95% confidence interval (CI) 0.71 to 0.98; one trial, n = 371; lozenges: RR 0.68; 95% CI 0.56 to 0.83; one trial, n = 342). A small trial showed reduced mean birthweights with vitamin B6 supplementation (weighted mean difference -0.23 kg; 95% CI -0.42 to -0.04; n = 33; one trial). We did not find any statistically significant differences in the risk of eclampsia (capsules: n = 1242; three trials; lozenges: n = 944; one trial), pre-eclampsia (capsules n = 1197; two trials; lozenges: n = 944; one trial) or low Apgar scores at one minute (oral pyridoxine: n = 45; one trial), between supplemented and non-supplemented groups. No differences were found in Apgar scores at one or five minutes, or breastmilk production between controls and women receiving oral (n = 24; one trial) or intramuscular (n = 24; one trial) loading doses of pyridoxine at labour. AUTHORS' CONCLUSIONS:There were few trials, reporting few clinical outcomes and mostly with unclear trial methodology and inadequate follow up. There is not enough evidence to detect clinical benefits of vitamin B6 supplementation in pregnancy and/or labour other than one trial suggesting protection against dental decay. Future trials assessing this and other outcomes such as orofacial clefts, cardiovascular malformations, neurological development, preterm birth, pre-eclampsia and adverse events are required.


Thaver D,Saeed MA,Bhutta ZA




Has Abstract


2006-04-19 00:00:00








  • Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.

    abstract:BACKGROUND:Ganoderma lucidum (also known as lingzhi or reishi) is a mushroom that has been consumed for its broad medicinal properties in Asia for over 2000 years. G lucidum is becoming increasingly popular in western countries as a complementary medicine for cardiovascular health. OBJECTIVES:To evaluate the effective...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Klupp NL,Chang D,Hawke F,Kiat H,Cao H,Grant SJ,Bensoussan A

    更新日期:2015-02-17 00:00:00

  • Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation.

    abstract:BACKGROUND:Chronic pulmonary infection is a hallmark of lung disease in cystic fibrosis. Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 18 closely-related species of gram-negative bacteria, are particularly difficult to treat. These infections may be associated with a fulmina...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章


    authors: Lord R,Jones AM,Horsley A

    更新日期:2020-04-02 00:00:00

  • WITHDRAWN: Psychological interventions for those who have sexually offended or are at risk of offending.

    abstract:BACKGROUND:Sexual offending is both a social problem and a public health issue. To date, no positive treatment effects have been found in quasi-experimental institutional treatment programmes. OBJECTIVES:To evaluate effects of psychological interventions on target sexual acts, urges or thoughts for people who have bee...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Kenworthy T,Adams CE,Bilby C,Brooks-Gordon B,Fenton M

    更新日期:2008-10-08 00:00:00

  • Oral Janus kinase inhibitors for maintenance of remission in ulcerative colitis.

    abstract:BACKGROUND:Tofacitinib is an oral Janus kinase (JAK) inhibitor which blocks cytokine signaling involved in the pathogenesis of autoimmune diseases including ulcerative colitis (UC). The etiology of UC is poorly understood, however research suggests the development and progression of the disease is due to a dysregulated...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Davies SC,Hussein IM,Nguyen TM,Parker CE,Khanna R,Jairath V

    更新日期:2020-01-27 00:00:00

  • Interventions for obsessive compulsive symptoms in people with schizophrenia.

    abstract::This is the protocol for a review and there is no abstract. The objectives are as follows: 1 PRIMARY OBJECTIVES:To evaluate clinically meaningful benefits of interventions used to treat clinically significant obsessive compulsive symptoms occurring in people with schizophrenia with regard to global improvement, chang...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章


    authors: Raj M,Farooq S

    更新日期:2005-01-01 00:00:00

  • Propentofylline for dementia.

    abstract:BACKGROUND:Propentofylline is a novel therapeutic agent for dementia that readily crosses the blood-brain barrier and acts by blocking the uptake of adenosine and inhibiting the enzyme phosphodiesterase. In vitro and in vivo its mechanism of action appears to be twofold; it inhibits the production of free radicals and ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Frampton M,Harvey RJ,Kirchner V

    更新日期:2003-01-01 00:00:00

  • Vaccines for preventing malaria (pre-erythrocytic).

    abstract:BACKGROUND:Vaccines against all stages of the malaria parasite are in development, mainly for Plasmodium falciparum, which causes the most serious form of malaria. Pre-erythrocytic vaccines act to prevent or delay a malaria attack by attacking the sporozoite and liver stages before the parasite reaches the bloodstream....

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Graves P,Gelband H

    更新日期:2006-10-18 00:00:00

  • Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery.

    abstract:BACKGROUND:Regional anaesthesia may reduce the rate of persistent (chronic) pain after surgery, a frequent and debilitating condition. OBJECTIVES:To compare local anaesthetics and regional anaesthesia versus conventional analgesia for the prevention of persistent pain six or 12 months after surgery. SEARCH METHODS:We...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Andreae MH,Andreae DA

    更新日期:2012-10-17 00:00:00

  • Slow-release oral morphine as maintenance therapy for opioid dependence.

    abstract:BACKGROUND:Opioid substitution treatments are effective in retaining people in treatment and suppressing heroin use. An open question remains whether slow-release oral morphine (SROM) could represent a possible alternative for opioid-dependent people who respond poorly to other available maintenance treatments. OBJECT...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Ferri M,Minozzi S,Bo A,Amato L

    更新日期:2013-06-05 00:00:00

  • Cholinesterase inhibitors for the treatment of delirium in non-ICU settings.

    abstract:BACKGROUND:Delirium is a common clinical syndrome defined as alterations in attention with an additional disturbance in cognition or perception, which develop over a short period of time and tend to fluctuate during the course of the episode. Delirium is commonly treated in hospitals or community settings and is often ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Yu A,Wu S,Zhang Z,Dening T,Zhao S,Pinner G,Xia J,Yang D

    更新日期:2018-06-28 00:00:00

  • Elemene for the treatment of lung cancer.

    abstract:BACKGROUND:Elemene, isolated from the Chinese medicinal herb Rhizoma Zedoariae and be used to treat patients with lung cancer in China. Until now, the effects have not been systematically reviewed. OBJECTIVES:The purpose of this review was to determine the effectiveness and safety of elemene in the treatment of patien...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Rui D,Xiaoyan C,Taixiang W,Guanjian L

    更新日期:2007-10-17 00:00:00

  • Head midline position for preventing the occurrence or extension of germinal matrix-intraventricular hemorrhage in preterm infants.

    abstract:BACKGROUND:Preterm birth is known to constitute the major risk factor for development of germinal matrix-intraventricular hemorrhage (GM-IVH). Head position may affect cerebral hemodynamics and thus may be involved indirectly in development of GM-IVH. Turning the head toward one side may functionally occlude jugular ve...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Romantsik O,Calevo MG,Bruschettini M

    更新日期:2017-07-20 00:00:00

  • Infant position in neonates receiving mechanical ventilation.

    abstract:BACKGROUND:A variety of body positions other than the standard supine position have been used in patients undergoing intensive care with hopes of reducing the incidence of pressure ulcers of the skin, contractures or ankylosis and improving the patients' well being. In patients from different age groups undergoing mech...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Balaguer A,Escribano J,Roqué i Figuls M,Rivas-Fernandez M

    更新日期:2013-03-28 00:00:00

  • Early versus late chest radiotherapy for limited stage small cell lung cancer.

    abstract:BACKGROUND:It is standard clinical practice to combine chemotherapy and chest radiotherapy in treating patients with limited-stage small cell lung cancer. However, the best way to integrate both modalities is unclear. OBJECTIVES:To establish the most effective way of combining chest radiotherapy with chemotherapy for ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Pijls-Johannesma MC,De Ruysscher D,Lambin P,Rutten I,Vansteenkiste JF

    更新日期:2005-01-25 00:00:00

  • Vitamin C and superoxide dismutase (SOD) for diabetic retinopathy.

    abstract:BACKGROUND:There is increasing evidence that diabetic retinopathy is caused by the action of free radicals. Radical scavengers like vitamin C and superoxide dismutase (SOD) may influence the outcome and progression of diabetic retinopathy, but no systematic review of the literature has been published to examine this hy...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Lopes de Jesus CC,Atallah AN,Valente O,Moça Trevisani VF

    更新日期:2008-01-23 00:00:00

  • Factors influencing the uptake and use of nicotine replacement therapy and e-cigarettes in pregnant women who smoke: a qualitative evidence synthesis.

    abstract:BACKGROUND:Nicotine replacement therapy (NRT) delivers nicotine without the toxic chemicals present in tobacco smoke. It is an effective smoking cessation aid in non-pregnant smokers, but there is less evidence of effectiveness in pregnancy. Systematic review evidence suggests that pregnant women do not adhere to NRT a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章


    authors: Campbell K,Coleman-Haynes T,Bowker K,Cooper SE,Connelly S,Coleman T

    更新日期:2020-05-22 00:00:00

  • Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain.

    abstract:BACKGROUND:There is increasing focus on providing high quality care for people at the end of life, irrespective of disease or cause, and in all settings. In the last ten years the use of care pathways to aid those treating patients at the end of life has become common worldwide. The use of the Liverpool Care Pathway in...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Wiffen PJ,Derry S,Moore RA

    更新日期:2014-05-29 00:00:00

  • Outcomes of patients who participate in randomised controlled trials compared to similar patients receiving similar interventions who do not participate.

    abstract:BACKGROUND:Some people believe that patients who take part in randomised controlled trials (RCTs) face risks that they would not face if they opted for non-trial treatment. Others think that trial participation is beneficial and the best way to ensure access to the most up to date physicians and treatments. OBJECTIVES...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Vist GE,Hagen KB,Devereaux PJ,Bryant D,Kristoffersen DT,Oxman AD

    更新日期:2007-04-18 00:00:00

  • Patient education for preventing diabetic foot ulceration.

    abstract:BACKGROUND:Ulceration of the feet, which can result in loss of limbs and even death, is one of the major health problems for people with diabetes mellitus. OBJECTIVES:To assess the effects of patient education on the prevention of foot ulcers in patients with diabetes mellitus. SEARCH METHODS:We searched The Cochrane...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Dorresteijn JA,Kriegsman DM,Assendelft WJ,Valk GD

    更新日期:2014-12-16 00:00:00

  • Medications for increasing milk supply in mothers expressing breastmilk for their preterm hospitalised infants.

    abstract:BACKGROUND:Breastmilk remains the optimal form of enteral nutrition for term and preterm infants until up to six months postnatal age. Mothers of preterm infants who have not established suck feeds must express their breastmilk and often have difficulty in maintaining sufficient volume for their infants' needs (Donath ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Donovan TJ,Buchanan K

    更新日期:2012-03-14 00:00:00

  • Maintenance immunosuppression for adults undergoing liver transplantation: a network meta-analysis.

    abstract:BACKGROUND:As part of liver transplantation, immunosuppression (suppressing the host immunity) is given to prevent graft rejections resulting from the immune response of the body against transplanted organ or tissues from a different person whose tissue antigens are not compatible with those of the recipient. The optim...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Rodríguez-Perálvarez M,Guerrero-Misas M,Thorburn D,Davidson BR,Tsochatzis E,Gurusamy KS

    更新日期:2017-03-31 00:00:00

  • Chinese herbal medicines for threatened miscarriage.

    abstract:BACKGROUND:Threatened miscarriage occurs in 10% to 15% of all pregnancies. Vaginal spotting or bleeding during early gestation is common, with nearly half of those pregnancies resulting in pregnancy loss. To date, there is no effective preventive treatment for threatened miscarriage. Chinese herbal medicines have been ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Li L,Dou L,Leung PC,Wang CC

    更新日期:2012-05-16 00:00:00

  • Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia.

    abstract:BACKGROUND:Recombinant factor VIIa (rFVIIa) is licensed for use in patients with haemophilia and inhibitory allo-antibodies. It is also increasingly being used for off-license indications to prevent bleeding in operations where blood loss is likely to be high, and/or to stop bleeding that is proving difficult to contro...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Lin Y,Stanworth S,Birchall J,Doree C,Hyde C

    更新日期:2011-02-16 00:00:00

  • Anticoagulation for heart failure in sinus rhythm.

    abstract:BACKGROUND:Patients with chronic heart failure (heart failure) are at risk of thromboembolic events, including stroke, pulmonary embolism and peripheral arterial embolism, whilst coronary ischaemic events also contribute to the progression of heart failure. Long-term oral anticoagulation is established in certain group...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Lip GY,Gibbs CR

    更新日期:2001-01-01 00:00:00

  • Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.

    abstract:BACKGROUND:This is an update of the original review that was published in The Cochrane Database of Systematic Reviews, 2009, Issue 2. Gestational trophoblastic neoplasia (GTN) are malignant disorders of the placenta that include invasive hydatidiform mole, choriocarcinoma, placental-site trophoblastic tumour (PSTT) and...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Deng L,Zhang J,Wu T,Lawrie TA

    更新日期:2013-01-31 00:00:00

  • Automated monitoring compared to standard care for the early detection of sepsis in critically ill patients.

    abstract:BACKGROUND:Sepsis is a life-threatening condition that is usually diagnosed when a patient has a suspected or documented infection, and meets two or more criteria for systemic inflammatory response syndrome (SIRS). The incidence of sepsis is higher among people admitted to critical care settings such as the intensive c...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Warttig S,Alderson P,Evans DJ,Lewis SR,Kourbeti IS,Smith AF

    更新日期:2018-06-25 00:00:00

  • Antibiotics for trachoma.

    abstract:BACKGROUND:Trachoma is the world's leading cause of preventable blindness. In 1997 the World Health Organization launched an initiative on trachoma control based on the 'SAFE' strategy (surgery, antibiotics, facial cleanliness and environmental improvement). OBJECTIVES:The aim of this review is to assess the evidence ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Mabey D,Fraser-Hurt N

    更新日期:2002-01-01 00:00:00

  • Interferon beta for secondary progressive multiple sclerosis.

    abstract:BACKGROUND:Therapy with either recombinant beta-1a or beta-1b interferons (IFNs) is worldwide approved for Relapsing Remitting Multiple Sclerosis (RRMS). A major unanswered question is whether this treatment is able to safely reverse or retard the progressive phase of the disease. OBJECTIVES:The main objective was to ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: La Mantia L,Vacchi L,Di Pietrantonj C,Ebers G,Rovaris M,Fredrikson S,Filippini G

    更新日期:2012-01-18 00:00:00

  • Methods for administering subcutaneous heparin during pregnancy.

    abstract:BACKGROUND:Pregnant women with a history of venous thromboembolism (VTE), antithrombin deficiency, or other risk factors for VTE, need heparin (unfractionated heparin (UFH) or low-molecular weight heparin (LMWH)) prophylaxis, mainly through administering subcutaneously. Several methods of administering heparin (UFH or ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Sasaki H,Yonemoto N,Hanada N,Mori R

    更新日期:2013-03-28 00:00:00

  • Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children.

    abstract:BACKGROUND:In children with urinary tract infection (UTI), only those with pyelonephritis (and not cystitis) are at risk for developing long-term renal sequelae. If non-invasive biomarkers could accurately differentiate children with cystitis from children with pyelonephritis, treatment and follow-up could potentially ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Shaikh N,Borrell JL,Evron J,Leeflang MM

    更新日期:2015-01-20 00:00:00