Abstract:
BACKGROUND:The aim of the study was to evaluate diurnal blood pressure (BP) profiles in patients with primary aldosteronism and to compare them to those in subjects with essential hypertension. The effects of specific therapy on the circadian BP profiles have been studied. MATERIALS AND METHODS:Sixty-four patients with primary aldosteronism were included in the study. Thirty of them revealed an aldosterone-producing adenoma (APA) and 34 had idiopathic hyperaldosteronism (IHA) due to bilateral adrenal hyperplasia. RESULTS:We did not find any significant differences in ambulatory BP monitoring (ABPM) between patients with APA and IHA. However, the circadian BP variation in the patients with primary hyperaldosteronism due to APA was preserved, while the patients with IHA showed lower nocturnal decline in comparison with patients with essential hypertension. There was a significant decline in office and ambulatory BP levels after treatment in the patients with both APA and IHA. The awake-sleep BP difference in patients with APA remained unchanged after surgical treatment, while in patients with IHA the night-time systolic and diastolic BP decline was significantly higher after spironolactone treatment. CONCLUSIONS:Primary hyperaldosteronism due to APA was associated with normal circadian BP variability and the surgical treatment led to highly significant decline in all BP parameters but had no influence on the extent of nocturnal BP variation. Spironolactone therapy restored normal nocturnal BP decline in patients with IHA. Reduction of night-time BP decline in patients with IHA is more likely to be related to the duration of the disease rather than to the aldosterone levels.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Zacharieva S,Orbetzova M,Elenkova A,Stoynev A,Yaneva M,Schigarminova R,Kalinov K,Nachev Edoi
10.1007/BF03349173keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
26-31issue
1eissn
0391-4097issn
1720-8386pii
1137journal_volume
29pub_type
杂志文章abstract:OBJECTIVE:To assess the relationship of waist circumference and weight/height ratio with height, and their association with components of the metabolic syndrome, in Type 2 diabetic patients. DESIGN:multicenter cross-sectional survey on a cohort enrolled in a prospective observational study. SUBJECTS:13,232 patients (...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,多中心研究
doi:10.1007/BF03347475
更新日期:2004-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
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更新日期:2012-11-01 00:00:00
abstract::Benign thyroid nodules represent a very common disorder, the management of which is still controversial. The aim of the present work was to evaluate by ultrasound examination the volume changes of thyroid nodules in post-menopausal women presenting single palpable nodular goiter of recent onset (less than 6 months fro...
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abstract::This study was performed to determine whether phenotypically healthy sisters of women with polycystic ovary syndrome (PCOS) have evidence of insulin resistance. We studied 54 women: 17 with PCOS, 17 sisters of these probands and 20 control women with similar age, body mass index (BMI) and waist-to-hip ratio (WHR). The...
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journal_title:Journal of endocrinological investigation
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abstract::Hyperthyroidism is rare in early childhood and most commonly caused by Graves' disease. We report 14 children (4 boys, 10 girls) aged 3.4-7.5 yr. At diagnosis, all patients had weight loss, hyperkinetic activity, tachycardia, difficulty sleeping, and poor concentration and 11 presented with proptosis. Four patients de...
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pub_type: 临床试验,杂志文章
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abstract::The in vivo suppressive effect of glucose and insulin on plasma free fatty acid concentrations was investigated in obese subjects with (n = 6) and without (n = 6) Type 2 (non-insulin-dependent) diabetes mellitus during a 4h-hyperglycemic glucose clamp (about 11.2 mmol/l). Somatostatin was infused (250 micrograms/h) du...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
abstract::To characterize natriuretic peptide receptor (NPr) gene expression in human tissues, we cloned portions of the cDNAs codifying for NPr with guanylyl cyclase activity (NPr-A and NPr-B) and without guanylyl cyclase activity (NPr-C). Total RNA was extracted from samples taken at surgery from normal human tissues. NPr-A a...
journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
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更新日期:2010-10-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349415
更新日期:1981-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350444
更新日期:1981-04-01 00:00:00
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更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Journal of endocrinological investigation
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更新日期:2005-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349069
更新日期:1988-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347894
更新日期:1991-09-01 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:1990-02-01 00:00:00
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journal_title:Journal of endocrinological investigation
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更新日期:1994-09-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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