Abstract:
:It has been shown that human calcitonin (hCT) is absorbed through the nasal mucosa when administered together with promoters like sodium glycocholate (SGC) or dihydrofusinate. The aim of this study was to compare the clinical and metabolic effect of intranasal (in) and intramuscular (im) hCT in patients with osteoporosis or with Paget's disease of bones. Fifteen women with postmenopausal or with senile osteoporosis entered a randomized six months trial with in hCT (plus SGC) or with im hCT 100 U on alternate days. Six women in each group were treated for 2 months, and only four women in each group continued treatment for an additional 4 months period. In hCT, but not im hCT, reduced subjective pain, while urinary cAMP increased to a similar extent in the 2 groups. Other metabolic indexes and bone mineral content (BMC) were unchanged, no new fractures took place, and side effects were fewer with in than with im hCT. To confirm the analgesic effect of in hCT, twelve patients with Paget's disease of bone were randomly treated for 20 days with in or im hCT 100 U/day: during the short period of treatment, pain was reduced by in, not by im hCT, and urinary cAMP excretion similarly increased in the two groups of patients.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Pontiroli AE,Pajetta E,Calderara A,Alberetto M,Pozza G,Manganelli V,Resmini G,Tessari L,Maresca Vdoi
10.1007/BF03350260keywords:
subject
Has Abstractpub_date
1991-01-01 00:00:00pages
47-51issue
1eissn
0391-4097issn
1720-8386journal_volume
14pub_type
临床试验,杂志文章,随机对照试验abstract::Although it is well known that growth hormone may influence protein metabolism, few investigations have been undertaken on serum protein levels in acromegaly; recently hypoglobulinemia has been observed in this endocrine disorder. In 28 acromegalic patients and 56 control subjects sera have been analyzed for total pro...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349317
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:Adiponectin has emerged over the last decade as a key adipokine linking obesity, insulin resistance, and Type 2 diabetes. However, the molecular mechanisms controlling adiponectin expression in adipose tissue are not fully elucidated. Furthermore, increasing evidence indicates that peroxisome proliferator-ac...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347056
更新日期:2011-02-01 00:00:00
abstract::Whole-body vibration is reported to increase muscle performance, bone mineral density and stimulate the secretion of lipolytic and protein anabolic hormones, such as GH and testosterone, that might be used for the treatment of obesity. To date, as no controlled trial has examined the effects of vibration exercise on t...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF03351056
更新日期:2004-04-01 00:00:00
abstract::The case of a 15-yr-old boy with C11 hydroxylase deficiency congenital adrenal hyperplasia is reported who was diagnosed and treated as true precocious puberty at the age of 2 yr because of virilization and bilateral testicular enlargement. He later developed hyperpigmentation, hypertension and short stature and becau...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03345128
更新日期:2003-01-01 00:00:00
abstract::Thyroid function tests were evaluated in 34 patients with acute viral hepatitis (AVH) and in 38 healthy controls (C). As expected, AVH patients displayed a significant increase in T4, rT3 and TBG serum levels with respect to C, while FT4 and TSH concentrations were similar. A positive correlation between TBG and T4 wa...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349947
更新日期:1989-03-01 00:00:00
abstract::No long-term data are available on the efficacy of glargine insulin in comparison with continuous sc insulin infusion (CSII) in children and adolescents affected by Type 1 diabetes (T1D). Our aim was to compare the 2-yr efficacy of the 2 insulin approaches, in order to know how to best supply basal insulin in these pa...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346351
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:Testosterone replacement therapy (TRT) is recommended for the treatment of most cases of male hypogonadism. Transdermal testosterone (T) gels are commonly used in clinical practice; however, there is little evidence concerning how to monitor dosage to bring and maintain serum T levels in the normal physiologic ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01082-x
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:We recently demonstrated a protective effect of the farnesoid X receptor agonist obeticholic acid (OCA) in rat models of bleomycin-induced pulmonary fibrosis (PF). Aim of the present study was to investigate whether the positive effects of OCA treatment are apparent also on ongoing bleomycin-induced PF, i.e., a...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-018-0913-1
更新日期:2019-03-01 00:00:00
abstract::Pituitary adenomas are common neoplasms requiring medical and/or surgical treatment when associated with hormonal hypersecretion. Treatment of non-functioning pituitary adenomas is necessary when symptoms of mass effect or hormonal deficits occur. However, therapeutic options, including surgical resection and/or radio...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347449
更新日期:2007-09-01 00:00:00
abstract::Resveratrol, the naturally occurring polyphenolic compound characterized by anti-oxidative, anti-inflammatory and apoptotic properties, appears to contribute substantially to cardioprotection and cancer-prevention. In addition, resveratrol is believed to regulate several biological processes, mainly metabolism and agi...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.3275/7926
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Depressive disorder encompasses a wide spectrum of somatic and psychological symptoms. It is not known whether there are differences regarding the cluster of depressive symptomatology between subjects with depression with and without T2DM. PURPOSE:To explore whether the cluster of depression that prevails a...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01020-x
更新日期:2019-08-01 00:00:00
abstract::We studied the possibility of an association between serum somatomedin-C (Sm-C) and thyroid hormone concentrations. For this purpose 34 hyperthyroid patients, 39 patients with primary hypothyroidism, 36 patients with severe nonthyroidal illnesses (NTI), and 63 euthyroid healthy control subjects were examined. The mean...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349528
更新日期:1990-02-01 00:00:00
abstract::It has previously been suggested that ghrelin mediates GH-independent biologic activities on the heart. We investigated the acute effects on cardiac contraction of a single iv administration of human ghrelin (in a dose of 1 microg/kg) in severe untreated GH deficient subjects. Prior to the ghrelin infusion, an echocar...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03347499
更新日期:2004-07-01 00:00:00
abstract::A dialyzable, thermostable inhibitor of normal thyroid peroxidase (TPO), with UV absorption maximum at 250-260 nm, was found in the digitonized, washed particulate fraction of two dyshormonogenetic goiters. No intrinsic TPO iodide-oxidation activity was detectable in either of these goiters, and their TPO iodination a...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349651
更新日期:1990-12-01 00:00:00
abstract::The authors report the profiles of luteinizing hormone (LH), estradiol (E2), progesterone (P) and androstenedione (A) in some female pigs with altered plasma hormonal levels. Twenty cycles are described and 19 out of them are characterized by low plasma P in luteal phase of different etiology, at least as measured by ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350557
更新日期:1983-02-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of testosterone treatment on biomarkers calprotectin, fibroblast growth factor 23 (FGF23), soluble Klotho, phosphate, calcium, parathyroid hormone, creatinine and estimated glomerular filtration rate. DESIGN:Randomized, double-blinded, placebo-controlled study. SETTING:Odense Andr...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s40618-016-0597-3
更新日期:2017-05-01 00:00:00
abstract::We report an original application of quantitative reverse transcription-polymerase chain reaction (Q.RT-PCR) for the evaluation of atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) and beta-actin mRNA in small atrial samples (10-15 mg). A fixed amount of total RNA was simultaneously reverse transcribed ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343655
更新日期:1999-12-01 00:00:00
abstract::The effect of an oral dose of 200 or 400 mg sodium valproate (DPA) on ACTH and cortisol secretion was assessed in 11 patients with Cushing's disease (3 bilaterally adrenalectomized), 3 patients with Nelson's syndrome and 6 patients with Addison's disease. In none of the patients examined DPA induced changes in ACTH (a...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03348396
更新日期:1984-04-01 00:00:00
abstract::The pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-017-0732-9
更新日期:2018-01-01 00:00:00
abstract::We summarized the clinical course of 10 patients with silent thyroiditis and evaluated the clinical usefulness of ultrasonography, in combination with clinical and laboratory findings, for the differentiation from Graves' disease. Serum T3 and T4 were increased in all cases, and the ratio of T3/T4 (ng/micrograms) was ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348732
更新日期:1992-04-01 00:00:00
abstract::Ghrelin is a 28-amino-acid hormone produced mainly by the stomach which strongly promotes food intake. It is the only known peripheral orexigenic hormone that induces the release of GH. Ghrelin has been proposed as a link between the enteric system and central regulation of energy balance and growth. Although it has r...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350806
更新日期:2007-10-01 00:00:00
abstract::Circulating TSH bioactivity may vary in several clinical and experimental conditions. Since the reliability of the current methods for the measurement of TSH bioactivity is limited, a new bioassay based on cAMP accumulation in Chinese Hamster Ovary cells transfected with recombinant human TSH receptor (CHO-R) was set ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348894
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To determine the difference of serum levels of 10 adipokines (apelin, chemerin, fatty acid-binding protein-4, fibroblast growth factor-21, monocyte chemoattractant protein-1, nesfatin-1, omentin-1, resistin, vaspin, and visfatin) among women with gestational diabetes and healthy pregnant controls. MATERIALS ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-018-0973-2
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Blepharophimosis syndrome (BPES) is an autosomal dominant genetic condition resulting from heterozygous mutations in the FOXL2 gene and clinically characterized by an eyelid malformation associated (type I) or not (type II) with premature ovarian failure. The distinction between the two forms is critical for ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-015-0334-3
更新日期:2016-02-01 00:00:00
abstract::The unlimited availability of GH obtained by recombinant DNA technology has allowed optimization of treatment in GH-deficient (GHD) children. At the same time it has prompted a number of studies in conditions not characterized by GHD such as Turner syndrome, intrauterine growth retardation, chronic renal failure and o...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/BF03345367
更新日期:2005-02-01 00:00:00
abstract::IGF-I stimulates protein synthesis, lowers blood glucose, and affects cell differentiation. The main production site of IGF-I is the liver. One of its binding proteins, IGFBP-1, is also produced by the liver. It is well known that ethanol affects the function of the human liver. Long-term alcohol abuse may therefore n...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343879
更新日期:2001-07-01 00:00:00
abstract:AIM:We investigated inpatients with and without Type 2 diabetes mellitus, aged over 60 yr, to compare their vitamin D status and calcium homeostatic parameters. MATERIALS AND METHODS:We studied 140 patients consecutively admitted to our Internal Medicine Unit during the year 2010 (61 from November to April, 79 from Ma...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8236
更新日期:2012-10-01 00:00:00
abstract::We evaluated the usefulness of premarin priming on exercise induced growth hormone release and the value of combining several growth hormone screening agents in a large population of prepubertal children. Two hundred five short healthy prepubertal children growing below the 5th percentile in height were studied. One h...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346963
更新日期:1986-12-01 00:00:00
abstract::We describe a patient with Cushing's syndrome and metastatic small cell lung cancer. The plasma ACTH concentrations were markedly elevated (91.6 pmol/L), and the AM cortisol did not suppress by > 50% overnight after administration of 8 mg dexamethasone, both consistent with the ectopic ACTH syndrome. Immunohistochemic...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347737
更新日期:1994-06-01 00:00:00
abstract:INTRODUCTION:Vitamin D (VD) insufficiency has been repeatedly observed in the medical conditions associated with inflammation, such as cardiovascular disease, diabetes and depression. However, contrasting to the observational evidence, randomized trials of VD supplementation failed to demonstrate such link. Given the r...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-014-0191-5
更新日期:2014-11-01 00:00:00