Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo.

abstract：:1. Emotional stress is one of the aetiologies of cardiac accidents, but the precise mechanisms remain to be elucidated. In the present study we used the immobilization stress model in rats to investigate electrocardiographic (ECG) changes. 2. A rapid elevation of the ST segment at the II, III, aVF and precordial leads...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ueyama T,Yoshida K,Senba E

更新日期：2000-05-01 00:00:00

abstract：:1. Administration of 2-thiophenecarboxylic acid to rats maintained on a low calcium diet resulted in a significant depression in the serum levels of total and ionized calcium and inorganic phosphate. 2. The serum magnesium levels were not altered by the drug. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Raman A,Chong YK

更新日期：1975-03-01 00:00:00

abstract：:1. Neutrophil function was studied in 10 males presenting with acute myocardial infarction (MI) within 6 h of onset and in 10 normal males. Neutrophil production of platelet-activating factor (PAF), determined by bioassay, that of leukotriene B4 by HPLC, and the activity of an enzyme involved in the synthesis of PAF, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Strahan ME,Graham RM,Eccleston DS,Sturm MJ,Taylor RR

更新日期：1995-02-01 00:00:00

abstract：:1. Mechanical stretch leads to cardiac hypertrophy and may ultimately cause heart failure. However, the effect of mechanical stretch on gene induction in cardiomyocytes remains to be determined. 2. In the present study, we compared transcript profiles of mechanically stretched neonatal rat cardiomyocytes with those of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cheng TH,Chen JJ,Shih NL,Lin JW,Liu JC,Chen YL,Chen CH,Chen JJ

更新日期：2009-05-01 00:00:00

abstract：:1. The purpose of this study was to determine whether hepatic mitochondria of guinea-pigs with spontaneous diabetes mellitus differ from those of non-diabetic guinea-pigs in the oxidation of fatty acids, the activity of beta-hydroxybutyrate dehydrogenase, or respiration-linked oxidative phosphorylation. During the cou...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nevalainen TO,White WJ,Lang CM,Munger BL

更新日期：1978-05-01 00:00:00

abstract：:1. To elucidate the physiological role of nitric oxide (NO) in regulating vascular tone, the effects of NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, on the vasoconstrictor response to noradrenaline (NA) in rat caudal artery was examined. 2. NG-Nitro-L-arginine methyl ester significantly potenti...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kwon YM,Shinozuka K,Kagota S,Yamaguchi Y,Nakamura K,Kunitomo M

更新日期：1999-05-01 00:00:00

abstract：:Studies in rats have shown that neomycin administration attenuates certain types of adrenocortical steroid dependent hypertension, including ACTH hypertension. The effects of oral neomycin on ACTH induced hypertension were examined in conscious sheep. Neomycin has no effect on the blood pressure or metabolic responses...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tresham J,Coghlan JP,Denton DA,Scoggins BA,Whitworth JA

更新日期：1984-11-01 00:00:00

abstract：:1. The present report documents evidence suggesting that endothelin (ET) is a mediator and modulator of post-ganglionic sympathetic neuronal development. 2. Endothelin is produced by post-ganglionic neurons and by cells adjacent to these neurons. 3. Post-ganglionic sympathetic neurons express functional receptors for ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Damon DH

更新日期：1999-12-01 00:00:00

abstract：:1. In order to determine whether the antihypertensive effect of neonatal thymectomy in genetically hypertensive rats could be mediated through altered adrenal function, systolic blood pressure (SBP) and urinary excretion of deoxycorticosterone (DOC), corticosterone (B) and aldosterone were measured in thymectomized hy...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bataillard A,Gomez-Sanchez CE,Vincent M,Touraine JL,Sassard J

更新日期：1988-11-01 00:00:00

abstract：:Diabetes mellitus and depressive disorders are both common chronic diseases that increase functional disability and social burden. Cognitive impairment is a potentially debilitating feature of depression. Previous evidence indicates that the antidiabetic drug metformin could be suitable for diabetic patients with cogn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Guo M,Mi J,Jiang QM,Xu JM,Tang YY,Tian G,Wang B

更新日期：2014-09-01 00:00:00

abstract：:1. (-)[125I]-Cyanopindolol (CYP) binding to non-beta-adrenoceptor sites in dog kidney was characterized in homogenate preparations and their distribution in sections determined using autoradiography. 2. In homogenate studies, (-)[125I]-CYP bound to a single population of non-interacting sites (Bmax = 5.45, s.e.m. = 1....

journal_title：Clinical and experimental pharmacology & physiology

authors： Lew R,Summers RJ

更新日期：1987-09-01 00:00:00

abstract：:1. Recent data from randomized controlled dietary trials have shown blood pressure-lowering effects of foodstuffs and dietary patterns to be of practical importance for both individual and population blood pressure control. 2. The salient studies include Dietary Approaches to Stop Hypertension (DASH) trials, on comple...

journal_title：Clinical and experimental pharmacology & physiology

authors： Beilin LJ,Burke V,Puddey IB,Mori TA,Hodgson JM

更新日期：2001-12-01 00:00:00

abstract：:1. There is mounting evidence that a wide range of antidepressants share the common feature of increasing hippocampal neurogenesis. The specificity of this association has suggested that an ability to increase neurogenesis might be a useful paradigm to screen for compounds with antidepressant activity. 2. The hope of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nandam LS,Jhaveri D,Bartlett P

更新日期：2007-05-01 00:00:00

abstract：:1. Erlotinib, a small-molecule epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitor, has been approved for the management of advanced non-small cell lung cancer. The aim of the present study was to investigate whether erlotinib exerts potent antitumour activities through the reactive oxygen species (RO...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qian X,Li J,Ding J,Wang Z,Zhang W,Hu G

更新日期：2009-05-01 00:00:00

abstract：:Osteosarcoma is the most common non-hematological primary bony malignancy in children and young adults with tumor metastasis being a common event at diagnosis. Understanding the pathogenesis of metastatic osteosarcoma may help identify potential therapeutic targets. In this study, we found that the level of microRNA-6...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiao GJ,Zhang SJ,Li Y,Wu WL,Liu HC

更新日期：2018-12-01 00:00:00

abstract：:1. The aim of this study was to compare the effect of acute versus chronic ADH administration on the handling of sodium, potassium and water by the nephron. Simultaneous clearance and free-flow micropuncture experiments were performed on rats, infused with hypotonic Ringer solution, following either 1-3 h ('acute') or...

journal_title：Clinical and experimental pharmacology & physiology

authors： Field MJ,Seow F,Lawrence JR

更新日期：1989-02-01 00:00:00

abstract：:1. The objectives of the study were to establish that inhibition of neuronal differentiation in culture (assessed by neurite outgrowth) can be used as a broad spectrum in vitro measure of neurotoxicity. 2. To establish whether a rapid measure of neurite outgrowth could be used. Thus the study examined the relationship...

journal_title：Clinical and experimental pharmacology & physiology

authors： Abdulla EM,Calaminici M,Campbell IC

更新日期：1995-05-01 00:00:00

abstract：:1. Endothelin mediates its effects in a variety of renal cells via a multiplicity of intracellular signalling pathways. 2. Stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC), resulting in the activation of inositol trisphosphate and diacylglycerol, can be detected even at picomolar concentrations of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nord EP

更新日期：1996-04-01 00:00:00

abstract：:1. Despite the array of sophisticated imaging techniques available for biological applications, none of the standard biomedical techniques adequately provides the capability to measure motion and flow. Those techniques currently in use are particularly lacking in spatial and temporal resolution. 2. Herein, we introduc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fouras A,Dusting J,Sheridan J,Kawahashi M,Hirahara H,Hourigan K

更新日期：2009-02-01 00:00:00

abstract：:1. To facilitate investigation of diverse rodent behaviours in rodents' home cages, we have developed an integrated modular platform, the SmartCage(™) system (AfaSci, Inc. Burlingame, CA, USA), which enables automated neurobehavioural phenotypic analysis and in vivo drug screening in a relatively higher-throughput and...

journal_title：Clinical and experimental pharmacology & physiology

authors： Khroyan TV,Zhang J,Yang L,Zou B,Xie J,Pascual C,Malik A,Xie J,Zaveri NT,Vazquez J,Polgar W,Toll L,Fang J,Xie X

更新日期：2012-07-01 00:00:00

abstract：:1. The effects on the coronary and systemic haemodynamics of intravenous and intracoronary injections of two benzfuran derivatives, amiodarone and its brominated analogue (L8040), were studied in open-chest anaesthetized dogs. The effects of L8040 on cardiac intracellular potentials after 6 weeks of 20 mg/kg intraperi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Singh BN,Jewitt DE,Downey JM,Kirk ES,Sonnenblick EH

更新日期：1976-09-01 00:00:00

abstract：:1. Renomedullary interstitial cells (RMIC), abundant throughout the medulla of the kidney, have been demonstrated to have binding sites for many vasoactive peptides, including atrial natriuretic peptide, endothelin, angiotensin II and bradykinin (BK). These observations would support the hypothesis that interactions b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dean R,Maric C,Aldred GP,Casley D,Zhuo J,Harris P,Alcorn D,Mendelsohn FA

更新日期：1999-01-01 00:00:00

abstract：:1. We examined the effects of torasemide (0.3 and 1 mg/kg i.v.) on renal haemodynamics and function employing renal clearance and stop-flow techniques in anaesthetized dogs and compared these with furosemide (1 and 3 mg/kg i.v.). 2. Torasemide and furosemide did not influence renal haemodynamics, in the renal clearanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Uchida T,Hayashi K,Suzuki Y,Matsumura Y

更新日期：1991-07-01 00:00:00

abstract：:1. Four, six and eight hours after gavage of rats with alpha-mercapto-beta-(2-furan)acrylic acid (MFA) (25 mg/kg) serum zinc concentration was increased ten-fold over control levels and a mean molar ratio of 1 albumin:0-4 zinc:0-8 MFA was found for seventeen sera. 2. At pH 7-5 a maximum of 1 mole of MFA could be bound...

journal_title：Clinical and experimental pharmacology & physiology

authors： Giroux E,Prakash NJ,Schechter PJ

更新日期：1977-01-01 00:00:00

abstract：:Agmatine, an endogenous ligand of imidazoline receptors, is reported to exhibit anti-hyperglycaemic and many other effects. It has been established that the imidazoline I3 receptor is involved in insulin secretion. The current study characterizes the role of the imidazoline I3 receptor in the protection of pancreatic ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li Y,Cheng KC,Asakawa A,Amitani H,Takimoto Y,Runtuwene J,Inui A

更新日期：2015-09-01 00:00:00

abstract：:1. Landrace swine were identified as malignant hyperpyrexia susceptible (MHS) or control by the contracture responses of gracilis muscle fibre bundles to 3% halothane, 2 mmol/l caffeine and 80 mmol/l KCl. The effects of calmodulin-antagonist drugs on the contractile behaviour of control and MHS preparations were inves...

journal_title：Clinical and experimental pharmacology & physiology

authors： Collins SP,White MD,Denborough MA

更新日期：1988-06-01 00:00:00

abstract：:1. The leucocyte-mediated inflammatory response plays a pivotal role in ischaemia-reperfusion injury. P-Selectin and CD11b are important mediators for the recruitment of leucocytes into the endothelium. However, the time-course of changes in P-selectin and CD11b expression during reperfusion is not defined. Magnesium ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ying SQ,Fang L,Xiang MX,Xu G,Shan J,Wang JA

更新日期：2007-12-01 00:00:00

abstract：:1. To determine whether total interruption of the local cardiac renin-angiotensin system by angiotensin II (AngII) receptor antagonist limits myocardial ischaemia, intracoronary (i.c.) or intravenous (i.v.) infusion of AngII receptor antagonists was compared in ischaemic dogs. 2. Dogs subjected to 90 min coronary arte...

journal_title：Clinical and experimental pharmacology & physiology

authors： So T,Nakashima Y,Imamura M,Arakawa K

更新日期：1998-07-01 00:00:00

abstract：:This study investigated if the protective effect of taurine against high fat diet-induced hepatic steatosis involves modulating the hepatic activity of 5' AMP-activated protein kinase (AMPK) and levels/activity of the sterol regulatory element-binding proteins-1/2 (SREBP1/2). Rats were divided into four groups (n = 12...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morsy MD,Aboonq MS,ALsleem MA,Abusham AA

更新日期：2020-07-21 00:00:00

abstract：:The purpose of the present study was to identify the differential proteins that synchronously change in urine and glomeruli and could be used to monitor glomerular lesions of IgA nephropathy (IgAN). The proteomes of urine and glomeruli from four IgAN patients who were graded III/IV according to the grading system of L...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ning X,Yin Z,Li Z,Xu J,Wang L,Shen W,Lu Y,Cai G,Zhang X,Chen X

更新日期：2017-05-01 00:00:00