Budesonide/formoterol and formoterol provide similar rapid relief in patients with acute asthma showing refractoriness to salbutamol.

abstract：:The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms, such as inflammation, in a broad range of chronic conditions has...

journal_title：Respiratory research

authors： He P,Gelissen IC,Ammit AJ

更新日期：2020-09-25 00:00:00

abstract：:The diagnosis of depression, a frequent comorbidity of chronic obstructive pulmonary disease (COPD), is often supported by questionnaires, such as the Patient Health Questionnaire 9 (PHQ-9). It is unknown to which extent its single questions are affected by the clinical characteristics of COPD patients.We addressed th...

journal_title：Respiratory research

authors： von Siemens SM,Jörres RA,Behr J,Alter P,Lutter J,Lucke T,Söhler S,Welte T,Watz H,Vogelmeier CF,Trudzinski F,Rief W,Herbig B,Kahnert K,COSYCONET study group.

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor metastasis is accelerated by...

journal_title：Respiratory research

authors： Li L,Ren F,Qi C,Xu L,Fang Y,Liang M,Feng J,Chen B,Ning W,Cao J

更新日期：2018-02-12 00:00:00

abstract：BACKGROUND:Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. METHODS:Based on the fact that postnatal regeneration of alveolar tissue has been attributed to alveolar epithelial cells, we established a hem...

journal_title：Respiratory research

authors： Zeng L,Yang XT,Li HS,Li Y,Yang C,Gu W,Zhou YH,Du J,Wang HY,Sun JH,Wen DL,Jiang JX

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin, an...

journal_title：Respiratory research

authors： Emson C,Diver S,Chachi L,Megally A,Small C,Downie J,Parnes JR,Bowen K,Colice G,Brightling CE

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural pathways may account for different components of clinical dyspnoea. Our objective was to evaluate i...

journal_title：Respiratory research

authors： Grogono JC,Butler C,Izadi H,Moosavi SH

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:A disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by activated leukocytes, and fibroblasts in vitro. Whether ADAM15 expression is increased in the lungs of COPD patients is not known. METHODS:ADAM15 gene expression and/or protein levels were measured in whole lung and bronchoalveolar lavag...

journal_title：Respiratory research

authors： Wang X,Zhang D,Higham A,Wolosianka S,Gai X,Zhou L,Petersen H,Pinto-Plata V,Divo M,Silverman EK,Celli B,Singh D,Sun Y,Owen CA

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:Impaired regulatory T cell (Treg) function is thought to contribute to ongoing inflammatory responses in sarcoidosis, but underlying mechanisms remain unclear. Moreover, it is not known if increased apoptotic susceptibility of Tregs may contribute to an impaired immunosuppressive function in sarcoidosis. The...

journal_title：Respiratory research

authors： Broos CE,van Nimwegen M,Kleinjan A,ten Berge B,Muskens F,in 't Veen JC,Annema JT,Lambrecht BN,Hoogsteden HC,Hendriks RW,Kool M,van den Blink B

更新日期：2015-09-16 00:00:00

abstract：BACKGROUND:Exhaled nitric oxide (F(E)NO) measurements are used as a surrogate marker for eosinophilic airway inflammation. However, many constitutional and environmental factors affect F(E)NO, making it difficult to devise reference values. Our aim was to evaluate the relative importance of factors affecting F(E)NO in ...

journal_title：Respiratory research

authors： Taylor DR,Mandhane P,Greene JM,Hancox RJ,Filsell S,McLachlan CR,Williamson AJ,Cowan JO,Smith AD,Sears MR

更新日期：2007-11-15 00:00:00

abstract：BACKGROUND:In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibros...

journal_title：Respiratory research

authors： Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G

更新日期：2011-09-26 00:00:00

abstract：BACKGROUND:Cognitive impairment has been found in chronic obstructive pulmonary disease (COPD) patients. However, the structural alteration of the brain and underlying mechanisms are poorly understood. METHODS:Thirty-seven mild-to-moderate COPD patients, forty-eight severe COPD patients, and thirty-one control subject...

journal_title：Respiratory research

authors： Li J,Fei GH

更新日期：2013-12-21 00:00:00

abstract：BACKGROUND:Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesity-related changes in the response to ozone in mice with diet-induced obesity. METHODS:Male wild...

journal_title：Respiratory research

authors： Kasahara DI,Shore SA

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provide an ideal source for stem-cell based therapy, mesenchymal stem cells (MSCs) remain the most popula...

journal_title：Respiratory research

authors： Dinh PC,Cores J,Hensley MT,Vandergriff AC,Tang J,Allen TA,Caranasos TG,Adler KB,Lobo LJ,Cheng K

更新日期：2017-06-30 00:00:00

abstract：RATIONALE:We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction. OBJECTIVES:Evaluate gender differences in respiratory factors associated with dyspnea in COPD patients. METHODS:In a FEV1 % matched population of 100 men and women with COPD we measured: age, MMRC, FEV1, ...

journal_title：Respiratory research

authors： de Torres JP,Casanova C,Montejo de Garcini A,Aguirre-Jaime A,Celli BR

更新日期：2007-03-06 00:00:00

abstract：BACKGROUND:High frequency chest wall oscillation (HFCWO) is used for airway mucus clearance. The objective of this study was to evaluate the use of HFCWO early in the treatment of adults hospitalized for acute asthma or chronic obstructive pulmonary disease (COPD). METHODS:Randomized, multi-center, double-masked phase...

journal_title：Respiratory research

authors： Mahajan AK,Diette GB,Hatipoğlu U,Bilderback A,Ridge A,Harris VW,Dalapathi V,Badlani S,Lewis S,Charbeneau JT,Naureckas ET,Krishnan JA

更新日期：2011-09-10 00:00:00

abstract：BACKGROUND:ABCA3 transporter (ATP-binding cassette transporter of the A subfamily) is localized to the limiting membrane of lamellar bodies, organelles for assembly and storage of pulmonary surfactant in alveolar epithelial type II cells (AECII). It transports surfactant phospholipids into lamellar bodies and absence o...

journal_title：Respiratory research

authors： Weichert N,Kaltenborn E,Hector A,Woischnik M,Schams A,Holzinger A,Kern S,Griese M

更新日期：2011-01-07 00:00:00

abstract：BACKGROUND:Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germa...

journal_title：Respiratory research

authors： Mueller S,Gottschalk F,Groth A,Meeraus W,Driessen M,Kohlmann T,Wilke T

更新日期：2018-08-30 00:00:00

abstract：BACKGROUND:β2 receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (Epac) was identified as another important signaling molecule of cAMP recently. The role of Epac in...

journal_title：Respiratory research

authors： Chen YF,Huang G,Wang YM,Cheng M,Zhu FF,Zhong JN,Gao YD

更新日期：2019-12-18 00:00:00

abstract：BACKGROUND:Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) is currently treated with systemic corticosteroids despite poor efficacy and side effects. This study investigated the therapeutic effect of budesonide/formoterol, montelukast and n-acetylcysteine, which a...

journal_title：Respiratory research

authors： Kim SW,Rhee CK,Kim YJ,Lee S,Kim HJ,Lee JW

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover studies, PT003011 and PT003012, investigating the 24-h lung function profile of GFF MDI (glycopyrrolate...

journal_title：Respiratory research

authors： Reisner C,Gottschlich G,Fakih F,Koser A,Krainson J,Delacruz L,Arora S,Feldman G,Pudi K,Siddiqui S,Orevillo C,Maes A,St Rose E,Martin U

更新日期：2017-08-18 00:00:00

abstract：BACKGROUND:Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight ...

journal_title：Respiratory research

authors： Jouneau S,Crestani B,Thibault R,Lederlin M,Vernhet L,Valenzuela C,Wijsenbeek M,Kreuter M,Stansen W,Quaresma M,Cottin V

更新日期：2020-11-25 00:00:00

abstract：:The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and potential involvement in several airway diseases has become increasingly recognized. In the current review, we focus on the contribution of select neuropeptides...

journal_title：Respiratory research

authors： Atanasova KR,Reznikov LR

更新日期：2018-08-06 00:00:00

abstract：RATIONALE:Smoking-induced chronic obstructive pulmonary disease (COPD) is associated with acquired systemic cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. Recently, sweat evaporimetry has been shown to efficiently measure β-adrenergic sweat rate and specifically quantify CFTR function in the se...

journal_title：Respiratory research

authors： Courville CA,Tidwell S,Liu B,Accurso FJ,Dransfield MT,Rowe SM

更新日期：2014-02-25 00:00:00

abstract：BACKGROUND:The receptor for advanced glycation end products (RAGE) is a multiligand signal transduction receptor that can initiate and perpetuate inflammation. Its soluble isoform (sRAGE) acts as a decoy receptor for RAGE ligands, and is thought to afford protection against inflammation. With the present study, we aime...

journal_title：Respiratory research

authors： Miniati M,Monti S,Basta G,Cocci F,Fornai E,Bottai M

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:There are limited series concerning Dieulafoy disease of the bronchus. We describe the clinical presentation of a series of 7 patients diagnosed with Dieulafoy disease of the bronchus and provide information about the pathological diagnosis approach. PATIENTS AND METHODS:A retrospective review of patients w...

journal_title：Respiratory research

authors： Parrot A,Antoine M,Khalil A,Théodore J,Mangiapan G,Bazelly B,Fartoukh M

更新日期：2008-08-05 00:00:00

abstract：BACKGROUND:Several studies have implicated a role of inflammation in the pathogenesis of lung damage in idiopathic pulmonary fibrosis (IPF). Parenchymal lung damage leads to defects in mechanics and gas exchange and clinically manifests with exertional dyspnea. Investigations of inflammatory cells in IPF have shown tha...

journal_title：Respiratory research

authors： Daniil Z,Kitsanta P,Kapotsis G,Mathioudaki M,Kollintza A,Karatza M,Milic-Emili J,Roussos C,Papiris SA

更新日期：2005-07-24 00:00:00

abstract：BACKGROUND:Hepcidin serves as a major regulator of systemic iron metabolism and immune function. Airway epithelial cells have an extensive interface with the environment, and so must be able to respond locally to the presence of particulates, infection, and inflammation. Therefore, we hypothesized that hepcidin is expr...

journal_title：Respiratory research

authors： Frazier MD,Mamo LB,Ghio AJ,Turi JL

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:Apoptosis has recently been proposed to contribute to the pathogenesis of emphysema. METHODS:In order to establish if cell fate plays a role even in end-stage disease we studied 16 lungs (9 smoking-associated and 7 alpha1antitrypsin (AAT)-deficiency emphysema) from patients who had undergone lung transplant...

journal_title：Respiratory research

authors： Calabrese F,Giacometti C,Beghe B,Rea F,Loy M,Zuin R,Marulli G,Baraldo S,Saetta M,Valente M

更新日期：2005-02-10 00:00:00

abstract：BACKGROUND:For decades, there is an unresolved debate about adequate prescription of antibiotics for patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this systematic review was to analyse randomised controlled trials investigating the clinical benefit of antibiotics for ...

journal_title：Respiratory research

authors： Puhan MA,Vollenweider D,Latshang T,Steurer J,Steurer-Stey C

更新日期：2007-04-04 00:00:00

abstract：BACKGROUND:Pleural effusion (PE) can be divided into benign pleural effusion (BPE) and malignant pleural effusion (MPE). There is no consensus on the identification of lung cancer-associated MPE using the optimal cut-off levels from five common tumor biomarkers (CEA, CYFRA 21-1, CA125, SCC-Ag, and NSE). Therefore, we a...

journal_title：Respiratory research

authors： Zhang H,Li C,Hu F,Zhang X,Shen Y,Chen Y,Li F

更新日期：2020-10-29 00:00:00