Neurotropic viruses and cerebral palsy: population based case-control study.

Abstract:

OBJECTIVE:To investigate the association between cerebral palsy and direct evidence for perinatal exposure to neurotropic viruses. DESIGN:Population based case-control study. SETTING:Adelaide Women's and Children's Hospital Research Laboratory. PARTICIPANTS AND MAIN OUTCOME MEASURES:Newborn screening cards of 443 white case patients with cerebral palsy and 883 white controls were tested for viral nucleic acids from enteroviruses and herpes viruses by using polymerase chain reaction. Herpes group A viruses included herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus 8 (HHV-8), and herpes group B viruses included varicella zoster virus (VZV) and human herpes viruses 6 and 7 (HHV-6 and HHV-7). RESULTS:The prevalence of viral nucleic acids in the control population was high: 39.8% of controls tested positive, and the prevalence was highest in preterm babies. The detection of herpes group B viral nucleic acids increased the risk of developing cerebral palsy (odds ratio 1.68, 95% confidence interval 1.09 to 2.59). CONCLUSIONS:Perinatal exposure to neurotropic viruses is associated with preterm delivery and cerebral palsy.

journal_name

BMJ

authors

Gibson CS,MacLennan AH,Goldwater PN,Haan EA,Priest K,Dekker GA,South Australian Cerebral Palsy Research Group.

doi

10.1136/bmj.38668.616806.3A

keywords:

subject

Has Abstract

pub_date

2006-01-14 00:00:00

pages

76-80

issue

7533

eissn

0959-8138

issn

1756-1833

pii

bmj.38668.616806.3A

journal_volume

332

pub_type

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