Type 2 diabetes mellitus in children and adolescents.

abstract：:We examined the distribution of nuclear T3 in mature rat brain with the aim of determining specific targets of thyroid hormones within this tissue. Saturation experiments, performed in 9 different structures of the brain and in 4 parts of the cortex, revealed the presence of a single class of binding sites with a mean...

journal_title：Journal of endocrinological investigation

authors： Ruel J,Faure R,Dussault JH

更新日期：1985-08-01 00:00:00

abstract：AIM:In the last years there has been a progressive reduction of the average duration of sleep and an increase in the incidence of sleep disturbances. At the same time, an increase of the incidence of the metabolic syndrome has been described, partly attributable to the progressive worsening of dietary habits and the in...

journal_title：Journal of endocrinological investigation

authors： Gramaglia E,Ramella Gigliardi V,Olivetti I,Tomelini M,Belcastro S,Calvi E,Dotta A,Ghigo E,Benso A,Broglio F

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study was to determine the protein pattern of human thyroid fine needle aspiration fluid (FNA) using a proteomic approach. FNA proteins were separated using 2-dimensional gel electrophoresis (2DE), digested and then analyzed by peptide mass fingerprinting. For the first time, we provided an image of th...

journal_title：Journal of endocrinological investigation

authors： Giusti L,Iacconi P,Ciregia F,Giannaccini G,Basolo F,Donatini G,Miccoli P,Lucacchini A

更新日期：2007-11-01 00:00:00

abstract：:Several in vivo experimental and clinical studies suggest that the production of thymic hormones, such as thymulin (Zn-FTS), is modulated by thyroid hormones. It was not determined in these studies, however whether such modulation is exerted directly on the thymic epithelial cells which synthesize and secrete thymic h...

journal_title：Journal of endocrinological investigation

authors： Mocchegiani E,Amadio L,Fabris N

更新日期：1990-02-01 00:00:00

abstract：:Formation of connective tissue is an essential step in the process of wound healing. After menopause an atrophy of connective tissues in skin, bone, and reproductive organs takes place. Using a dead-space wound healing model we measured collagen synthesis and deposition, and cell replication in the granulation tissue ...

journal_title：Journal of endocrinological investigation

authors： Gniadecki R,Wyrwas B,Kabala A,Matecka J

更新日期：1996-04-01 00:00:00

abstract：:Anorexia nervosa (AN) is an eating disorder characterized by self-induced starvation due to fear of adiposity. Ghrelin, gastric peptide with potent orexigenic, adipogenic, GH-releasing and metabolic properties, is elevated in AN. We have previously shown that intervention with exogenous ghrelin is not effective in ter...

journal_title：Journal of endocrinological investigation

authors： Miljic D,Djurovic M,Pekic S,Doknic M,Stojanovic M,Milic N,Casanueva FF,Ghatei M,Popovic V

更新日期：2007-10-01 00:00:00

abstract：:Growth hormone (GH), insulin-like growth factor-1 (IGF-1) and prolactin (PRL) in blood and urine were observed in 20 patients with acromegaly in a double-blind placebo-controlled 14-day clinical trial with the somatostatin analog octreotide. Hormones were determined by the same radioimmunoassays in blood and urine. Si...

journal_title：Journal of endocrinological investigation

authors： Fredstorp L,Werner S

更新日期：1993-04-01 00:00:00

abstract：:Recent evidence suggests that patients with traumatic brain injury (TBI) are at substantial risk of hypopituitarism. The pathomechanisms, however, are not completely understood yet. Little is known about the association of morphological changes in the sella region with pituitary function in TBI. In this study, we asse...

journal_title：Journal of endocrinological investigation

authors： Schneider HJ,Sämann PG,Schneider M,Croce CG,Corneli G,Sievers C,Ghigo E,Stalla GK,Aimaretti G

更新日期：2007-04-01 00:00:00

abstract：:Numerous clinical and experimental reports suggest that a high von Willebrand factor (vWf) level reflects endothelial damage or endothelial dysfunction. The present study was designed to evaluate vWf in subclinical hyperthyroidic subjects compared with euthyroidic subjects. We selected 20 subclinical hyperthyroidic su...

journal_title：Journal of endocrinological investigation

authors： Coban E,Aydemir M,Yazicioglu G,Ozdogan M

更新日期：2006-03-01 00:00:00

abstract：:It has recently been suggested that the classical routine of glucocorticoid administration before and after transsphenoidal surgery (TSS) in Cushing's disease (CD) patients may not be necessary, since it is likely that peritumoral normal corticotrophs are not completely suppressed during this period. We compared the d...

journal_title：Journal of endocrinological investigation

authors： Pimentel-Filho FR,Silva ME,Nogueira KC,Berger K,Cukiert A,Liberman B

更新日期：2005-06-01 00:00:00

abstract：:Scavenger receptor A (SR-A) is the main receptor through which oxidized LDL (oxLDL) and advanced glycation end products get into the cells. The aim of the present study was to investigate the effect of an ACE inhibitor, perindopril, on the expression of SR-A in renal tubulointerstitium of diabetic rats. Diabetes was i...

journal_title：Journal of endocrinological investigation

authors： Sun L,Wen JH,Sun HL,Shu XC,Hu F,Yin DC,Yang Q,Zeng YJ,Sun Y,Liu L

更新日期：2012-05-01 00:00:00

abstract：:The aim of this paper is to briefly review some practical aspects of the relationship between thyroid function and several disorders of the hemostatic system in terms of bleeding and thrombosis. Thrombocytopenia, acquired hemophilia, hypercoagulability, cardioembolism and other biochemical coagulative and fibrinolytic...

journal_title：Journal of endocrinological investigation

authors： Marongiu F,Cauli C,Mariotti S

更新日期：2004-12-01 00:00:00

abstract：:Pathogenesis of idiopathic diabetes insipidus is unknown and the clinical course of the disease is permanent. However, we observed one patient who was diagnosed of idiopathic diabetes insipidus spontaneously reverted after approximately 13 months. The cause and pathogenesis of the disease were not evident. However, so...

journal_title：Journal of endocrinological investigation

authors： Ohshima K,Okada S,Onai T,Umahara M,Mori M,Kobayashi I,Kobayashi S,Katakai S

更新日期：1989-11-01 00:00:00

abstract：:Estrogen deficiency in females and androgen deficiency in males may harm periosteal and endosteal apposition, reduce bone size and both cortical and trabecular thickness, modifying in this way the bone structure later in life. To date, few systematic studies on bone mineral density (BMD) and hypogonadism in adolescent...

journal_title：Journal of endocrinological investigation

authors： Fintini D,Grossi A,Brufani C,Fiori R,Ubertini G,Pecorelli L,Cappa M

更新日期：2009-07-01 00:00:00

abstract：:The aim of acromegaly treatment is to control the disease by suppressing GH hyperactivity and reducing the size or impeding the growth of the pituitary GH secreting mass. Over recent years, many studies have emphasized the role of SS analogs in the treatment of acromegaly. In fact, SS analogs have been demonstrated to...

journal_title：Journal of endocrinological investigation

authors： Gola M,Bonadonna S,Mazziotti G,Amato G,Giustina A

更新日期：2006-01-01 00:00:00

abstract：:Severe bleeding into the peritoneal cavity from a ruptured ovulatory follicle is a rare complication in women receiving anticoagulation therapy. A number of both surgical and non surgical methods have been proposed to solve this problem. We adopted a novel therapeutic approach in a 40-year old patient who presented wi...

journal_title：Journal of endocrinological investigation

authors： Ulrich U,Rossmanith WG

更新日期：1994-05-01 00:00:00

abstract：:We evaluated the effect of six-month treatment with growth hormone (GH) or low-dose oxandrolone in a group of boys with constitutional growth delay (CGD). Sixteen boys were randomly assigned to two treatment groups. Group 1 received GH (0.6 U/kg/week sc 5-6 times/week) and Group 2 received oxandrolone (0.07 mg/kg po)....

journal_title：Journal of endocrinological investigation

authors： Loche S,Pintor C,Cambiaso P,Lampis A,Carta D,Corda R,Cappa M

更新日期：1991-10-01 00:00:00

abstract：:The syndrome of apparent mineralocorticoid syndrome (AME) results from defective 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2). This enzyme is co-expressed with the mineralocorticoid receptor (MR) in the kidney and converts cortisol to its inactive metabolite cortisone. Its deficiency allows the unmetabolized co...

journal_title：Journal of endocrinological investigation

authors： Palermo M,Delitala G,Sorba G,Cossu M,Satta R,Tedde R,Pala A,Shackleton CH

更新日期：2000-07-01 00:00:00

abstract：:Graves' disease (GD) is the most prevalent cause of thyrotoxicosis in children. Because spontaneous and lasting resolution of this condition occurs in only a minority of patients, most pediatric patients with GD will need radioactive iodine treatment (131I) or thyroidectomy. Whereas the medication propylthiouracil (PT...

journal_title：Journal of endocrinological investigation

authors： Rivkees SA

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Carcinoids are mainly found in the gastrointestinal (65%) and bronchopulmonary tract (25%). These neuroendocrine tumors secrete a wide range of bioactive peptides, including gastrin releasing peptide and neuromedin B, the mammalian analogs of bombesin. The purpose of this study was to investigate the quant...

journal_title：Journal of endocrinological investigation

authors： Kuiper P,Verspaget HW,Biemond I,de Jonge-Muller ES,van Eeden S,van Velthuysen ML,Taal BG,Lamers CB

更新日期：2011-10-01 00:00:00

abstract：CONTEXT:The latest guidelines of the 4th International Workshop on Asymptomatic Primary Hyperparathyroidism (aPHPT) reintroduced hypercalciuria (i.e. urinary calcium > 400 mg/day) as criterion for surgery. However, the value of hypercalciuria as a predictor of nephrolithiasis and the correct cut-off values still need t...

journal_title：Journal of endocrinological investigation

authors： Saponaro F,Cetani F,Mazoni L,Apicella M,Di Giulio M,Carlucci F,Scalese M,Pardi E,Borsari S,Bilezikian JP,Marcocci C

更新日期：2020-05-01 00:00:00

abstract：:Thyroid hormone acts on the oocytes, sperm and embryo during fertilization, implantation and placentation. Both hypothyroidism and hyperthyroidism may influence fertility. However, evidence of the association of hyperthyroidism with infertility is scarce and sometimes conflicting. Thyroid hormone influences human repr...

journal_title：Journal of endocrinological investigation

authors： Mintziori G,Kita M,Duntas L,Goulis DG

更新日期：2016-08-01 00:00:00

abstract：:We investigated the presence of mutations/polymorphisms in the FSH receptor (FSHR) gene and their association with phenotype in women with premature ovarian failure (POF) in southern Brazil. Clinical and hormonal variables were determined in 36 46,XX women with primary or secondary amenorrhea before the age of 40 yr, ...

journal_title：Journal of endocrinological investigation

authors： Vilodre LC,Kohek MB,Spritzer PM

更新日期：2008-06-01 00:00:00

abstract：:Leptin may be a possible trigger for puberty. In normal males, it has been shown that leptin increases from the pre-pubertal to the early pubertal stage, and then declines in the late pubertal stage. We examined leptin levels in six male adolescents (mean age 16.3+/-0.6 yr; range 14.2-17.6 yr) with delayed puberty (co...

journal_title：Journal of endocrinological investigation

authors： Giusti M,Guido R,Valenti S,Giordano G

更新日期：1999-01-01 00:00:00

abstract：:Human amniotic fluid (HAF) contains multipotent stem cells [amniotic fluid-derived stem cells (AFSC)] which can differentiate into a variety of different cell types. Recently, we demonstrated that obestatin, a peptide encoded by the ghrelin gene, exerts anti-apoptotic effects in pancreatic beta-cells and human islets ...

journal_title：Journal of endocrinological investigation

authors： Trovato L,De Fazio R,Annunziata M,Sdei S,Favaro E,Ponti R,Marozio L,Ghigo E,Benedetto C,Granata R

更新日期：2009-12-01 00:00:00

abstract：:General dynamic penile color doppler ultrasound (D-PCDU) screening in patients with erectile dysfunction (ED) has been questioned due to an inadequate cost-benefit ratio. The aim of the present study is to evaluate the validity of different risk scores in the identification of patients being screened for arteriogenic ...

journal_title：Journal of endocrinological investigation

authors： Corona G,Mannucci E,Fisher AD,Lotti F,Bandini E,Vignozzi L,Balercia G,Paggi F,Petrone L,Forti G,Maggi M

更新日期：2008-12-01 00:00:00

abstract：:The possible role of the renin-angiotensin system and ACTH in controlling the temporal organization of circadian rhythm of aldosterone was studied in patients with mesor-hypertension (MH) by simultaneous radioimmunological determinations of within-day changes in plasma renin, aldosterone and cortisol. Thirty-nine unco...

journal_title：Journal of endocrinological investigation

authors： Cugini P,Manconi R,Serdoz R,Mancini A,Meucci T,Scavo D

更新日期：1980-04-01 00:00:00

abstract：:Seventy years after the first successful radioiodine treatment of metastatic differentiated thyroid cancer (DTC), radioiodine (131I) therapy for this type of tumor is still without alternative. During the last decade, some key issues such as individual dosimetry, and preparation of 131I therapy by recombinant human TS...

journal_title：Journal of endocrinological investigation

authors： Luster M,Hänscheid H,Freudenberg LS,Verburg FA

更新日期：2012-01-01 00:00:00

abstract：:Data concerning the cardiovascular manifestations of primary hyperparathyroidism (PHPT) are inconsistent, which is due, in part, to the decrease in disease severity over the last several decades. In areas where patients tend to be more symptomatic, data support the presence of cardiovascular findings including myocard...

journal_title：Journal of endocrinological investigation

authors： Walker MD,Silverberg SJ

更新日期：2008-10-01 00:00:00

abstract：:Adrenal origin and ACTH-dependent secretion of endogenous digitalis-like factor(s) (EDLF) was investigated. Twelve normal weight normotensive subjects (normal group) and 10 patients with Addison's disease (Addison group) were subjected to prolonged ACTH stimulation with 1 mg tetracosactin-depot im. Blood sampling was ...

journal_title：Journal of endocrinological investigation

authors： Sophocleous A,Elmatzoglou I,Souvatzoglou A

更新日期：2003-07-01 00:00:00