Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma.

Abstract:

:Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic resonance imaging demonstrated a pituitary tumor. The surgically removed sellar mass was investigated by histology, immunocytochemistry and electron microscopy. Morphologic study revealed a collision tumor; one was a somatotroph adenoma, the other a gonadotroph adenoma. Authors call attention to the difficulties in clinical, imaging and pathological diagnosis. Detailed morphologic studies are needed to establish the presence of two distinct tumors composed of two different cell types.

journal_name

J Endocrinol Invest

authors

Syro LV,Horvath E,Kovacs K

doi

10.1007/BF03343674

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

37-41

issue

1

eissn

0391-4097

issn

1720-8386

journal_volume

23

pub_type

杂志文章
  • Proteomic analysis of human thyroid fine needle aspiration fluid.

    abstract::The aim of this study was to determine the protein pattern of human thyroid fine needle aspiration fluid (FNA) using a proteomic approach. FNA proteins were separated using 2-dimensional gel electrophoresis (2DE), digested and then analyzed by peptide mass fingerprinting. For the first time, we provided an image of th...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349229

    authors: Giusti L,Iacconi P,Ciregia F,Giannaccini G,Basolo F,Donatini G,Miccoli P,Lucacchini A

    更新日期:2007-11-01 00:00:00

  • Peptide receptor radionuclide therapy with 177Lu-DOTA-TATE as a promising treatment of malignant insulinoma: a series of case reports and literature review.

    abstract:INTRODUCTION:Insulinomas are a rare type of pancreatic neuroendocrine tumours characterized by insulin hypersecretion. They are considered malignant when metastases are present. Traditional therapies often promote only temporarily symptomatic relief and may be associated with severe adverse effects. There is scarce exp...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-018-0911-3

    authors: Magalhães D,Sampaio IL,Ferreira G,Bogalho P,Martins-Branco D,Santos R,Duarte H

    更新日期:2019-03-01 00:00:00

  • Transoral thyroidectomy: a viable surgical option with unprecedented complications-a case series.

    abstract:PURPOSE:To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS:From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0808-6

    authors: Bakkar S,Al Hyari M,Naghawi M,Corsini C,Miccoli P

    更新日期:2018-07-01 00:00:00

  • Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features.

    abstract::Pituitary adenomas are common neoplasms requiring medical and/or surgical treatment when associated with hormonal hypersecretion. Treatment of non-functioning pituitary adenomas is necessary when symptoms of mass effect or hormonal deficits occur. However, therapeutic options, including surgical resection and/or radio...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347449

    authors: Ballian N,Chrisoulidou A,Nomikos P,Samara C,Kontogeorgos G,Kaltsas GA

    更新日期:2007-09-01 00:00:00

  • Primary hyperparathyroidism in pregnancy: observations from the Indian PHPT registry.

    abstract:PURPOSE:To present the data on primary hyperparathyroidism (PHPT) in pregnancy from India obtained from a large database maintained over 15 years. METHODS:We retrieved data of all women with gestational PHPT from the Indian PHPT registry between July 2005 and January 2020, and compared their clinical, biochemical, and...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01441-z

    authors: Pal R,Bhadada SK,Gupta N,Behera A,Aggarwal N,Aggarwal A,Raviteja KV,Saikia UN,Kaur G,Arvindbhai SM,Walia R

    更新日期:2020-10-09 00:00:00

  • Primary hypothyroidism associated with secondary adrenocortical insufficiency.

    abstract::A 50 year old man is described in whom primary hypothyroidism and isolated ACTH deficiency leading to adrenocortical insufficiency occurred simultaneously. Low thyroid hormone levels, elevated serum TSH values and high titers of antithyroid antibodies (ATA) were consistent with primary hypothyroidism. The diagnosis of...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348331

    authors: Roosens B,Maes E,Van Steirteghem A,Vanhaelst L

    更新日期:1982-07-01 00:00:00

  • Effect of alpha-1-blockade by prazosin on blood sugar, insulin and glucagon levels in normals and non-insulin dependent diabetics.

    abstract::The AA. studied the glycometabolic activity of prazosin, a hypotensive drug with an adrenergic blocking activity of alpha-1-selective type. Twenty-two moderately hypertensive subjects were studied. Their ages ranged from 37 to 57 years; 10 of the patients had non-insulin dependent diabetes mellitus. After overnight fa...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03350608

    authors: Ferlito S,Puleo F,Carrà G,Damante G,Di Vincenzo S,Del Campo F

    更新日期:1983-06-01 00:00:00

  • Differences in the cluster of depressive symptoms between subjects with type 2 diabetes and individuals with a major depressive disorder and without diabetes.

    abstract:BACKGROUND:Depressive disorder encompasses a wide spectrum of somatic and psychological symptoms. It is not known whether there are differences regarding the cluster of depressive symptomatology between subjects with depression with and without T2DM. PURPOSE:To explore whether the cluster of depression that prevails a...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-019-01020-x

    authors: Nicolau J,Simó R,Conchillo C,Sanchís P,Blanco J,Romerosa JM,Fortuny R,Bonet A,Masmiquel L

    更新日期:2019-08-01 00:00:00

  • 5-HT2 receptors are partially involved in the relationship between renin release and delta relative power.

    abstract::A strong relationship was previously described between the nocturnal oscillations of plasma renin activity (PRA) and the sleep cycles, with levels of PRA that increase during non rapid eye movement sleep and decrease during rapid eye movement sleep. This study was designed to determine whether ritanserin, a 5-hydroxyt...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03349016

    authors: Brandenberger G,Luthringer R,Muller G,Gronfier C,Schaltenbrand N,Macher JP,Muzet A,Follenius M

    更新日期:1996-09-01 00:00:00

  • Insulin receptor binding and degradation in IM-9 cultured human lymphocytes - importance of extracellular degradation.

    abstract::Insulin degradation in IM-9 cultured human lymphocytes occurs extracellularly. In the presence of 0.1% bovine serum albumin, insulin degradation products are formed that are soluble in 5% trichloroacetic acid. In the presence of 5% bovine serum albumin, the major products of insulin degradation are insoluble in 5% tri...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348223

    authors: Misbin RI,Mehl TD

    更新日期:1980-01-01 00:00:00

  • Thyroid function tests in acute viral hepatitis: relative reduction in serum thyroxine levels due to T4-TBG binding inhibitors in patients with severe liver cell necrosis.

    abstract::Thyroid function tests were evaluated in 34 patients with acute viral hepatitis (AVH) and in 38 healthy controls (C). As expected, AVH patients displayed a significant increase in T4, rT3 and TBG serum levels with respect to C, while FT4 and TSH concentrations were similar. A positive correlation between TBG and T4 wa...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349947

    authors: Pagliacci MC,Pelicci G,Francisci D,Giammartino C,Fedeli L,Stagni G,Nicoletti I

    更新日期:1989-03-01 00:00:00

  • Effects of two different somatostatin analogs on glucose tolerance in acromegaly.

    abstract::Impaired glucose tolerance is present in many acromegalic patients and treatment with somatostatin analogs has variable effects on glycemic control. The aim of this study was to compare the effects of 2 somatostatin analogs on glucose metabolism, lanreotide slow release (L-SR) and octreotide long acting release (O-LAR...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03345491

    authors: Ronchi C,Epaminonda P,Cappiello V,Beck-Peccoz P,Arosio M

    更新日期:2002-06-01 00:00:00

  • Spot urinary iodine concentration as a measure of dietary iodine, evaluated in over 3800 young male subjects undergoing medical check-up preliminary to military enrolment in Piemonte and Aosta Valley (Italy).

    abstract::The aim of the study was to assess iodine status in over 3800 young male subjects aged 18, living in 6 different provinces of Piemonte and in Aosta Valley, Italy. A cross-sectional study on 3837 young male subjects undergoing medical evaluation preliminary to military enrolment was performed. Spot urine samples were o...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349155

    authors: Fonzo D,Germano L,Gallone G,Migliardi M

    更新日期:2003-12-01 00:00:00

  • The association between circulating irisin levels and different phenotypes of polycystic ovary syndrome.

    abstract:PURPOSE:The diagnosis of polycystic ovary syndrome (PCOS) is based on a combination of various clinical phenotypes in each patient. However, insulin resistance (IR) and dysmetabolism are not included in the diagnostic criteria of PCOS. Therefore, the definition of PCOS is controversial. The objective of this study is t...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-018-0902-4

    authors: Zhang L,Fang X,Li L,Liu R,Zhang C,Liu H,Tan M,Yang G

    更新日期:2018-12-01 00:00:00

  • Hyperinsulinemic hypoglycemia associated with ectopic Cushing's syndrome due to a pancreatic endocrine tumor in a Type 2 diabetes mellitus patient: clinical implications of a rare association.

    abstract:BACKGROUND:The coexistence of insulin and ACTH hypersecretion in the same patient is extremely rare. A diabetic patient with a pancreatic endocrine tumor (PET) co-secreting insulin and ACTH is even rarer and has never been described. The combination of these two endocrine syndromes results in a peculiar clinical pictur...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347062

    authors: Filippella M,Davì MV,Doveri G,Lillaz E,Ciccarelli A,Massimetti E,Toaiari M,Falconi M,Colao A,Faggiano A

    更新日期:2011-03-01 00:00:00

  • Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study.

    abstract:PURPOSE:Arginine vasopressin (AVP) may be involved in metabolic syndrome (MetS) by altering liver glycogenolysis, insulin and glucagon secretion, and pituitary ACTH release. Moreover, AVP stimulates the expression of 11β-hydroxysteroid-dehydrogenase-type 2 (11β-HSD2) in mineralocorticosteroid cells. We explored whether...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0807-7

    authors: Canivell S,Mohaupt M,Ackermann D,Pruijm M,Guessous I,Ehret G,Escher G,Pechère-Bertschi A,Vogt B,Devuyst O,Burnier M,Martin PY,Ponte B,Bochud M

    更新日期:2018-07-01 00:00:00

  • The 769G>A variant of the inhibin-alpha gene in Korean patients with preeclampsia.

    abstract:OBJECTIVE:Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A v...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346418

    authors: Kim SY,Lim JH,Yang JH,Kim MY,Kim MH,Park SY,Ryu HM

    更新日期:2008-08-01 00:00:00

  • Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism.

    abstract::The pituitary and peripheral responses to L-T4 and L-T3 therapy were studied in 12 patients with congenital goitrous hypothyroidism, in 10 patients with an ectopic thyroid and onset of hypothyroidism at 3-8 years of age, and in 6 patients with adult-onset hypothyroidism, after they had had their chronic thyroid hormon...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348554

    authors: Cavaliere H,Medeiros-Neto GA,Rosner W,Kourides IA

    更新日期:1985-12-01 00:00:00

  • Positive association of serum interleukin-1beta and CRH levels in women with pre-term labor.

    abstract:OBJECTIVE:The aim of this study was to investigate the hypothesis that interleukin-1beta (IL-1beta) might be involved in the increase of the circulating levels of placental-derived CRH leading to the initiation of pre-term labor. SUBJECTS AND METHODS:Forty-eight primigravidae with a singleton viable pregnancy between ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347393

    authors: Vitoratos N,Mastorakos G,Kountouris A,Papadias K,Creatsas G

    更新日期:2007-01-01 00:00:00

  • Synthesis of esters of androgens with unsaturated fatty acids for androgen requiring therapy.

    abstract::Androgens' metabolism and activity are gaining a more and more important role in human physiology particularly referring to aging and to neurodegenerative diseases. Androgen treatment is often required for long-lasting disorders. In order to improve their duration and effects, androgens can be administered as esters o...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8655

    authors: Aiello F,Garofalo A,Aloisi AM,Lamponi S,Magnani A,Petroni A

    更新日期:2013-06-01 00:00:00

  • Metastatic thyroid carcinoma of the adrenal gland.

    abstract::Follicular thyroid carcinoma may spread distant metastases in sites such as bone, lung and brain. In our series of 448 patients with follicular thyroid carcinoma, distant metastases were present in 25% of cases. We report here a case of follicular thyroid carcinoma with a single metastasis at the right adrenal gland, ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347667

    authors: Girelli ME,Casara D,Rubello D,Piccolo M,Piotto A,Pelizzo MR,Busnardo B

    更新日期:1993-02-01 00:00:00

  • A case of hypersensitivity to thyroid hormones with normally functioning thyroid gland and increased nuclear triiodothyronine receptors.

    abstract::A 52-year-old male presented himself with tachycardia crises which appeared first during childhood, increased in frequency without goiter or exophthalmos. Cardiac and adrenergic diseases were excluded. The thyroid function was normal regarding T4, free T4 and T3, TBG, radioiodine uptake, TSH and T3 suppressibility; ho...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349636

    authors: Jaffiol C,Baldet L,Torresani J,Bismuth J,Papachristou C

    更新日期:1990-11-01 00:00:00

  • Arterial erectile dysfunction: reliability of new markers of endothelial dysfunction.

    abstract:OBJECTIVE:Blood endothelial progenitor cells (EPC) and microparticles (EMP) have been proposed as markers of endothelial dysfunction. Aim of this study was to evaluate a new immunophenotype of EPC and EMP in patients with arterial erectile dysfunction (AED) compared to psychogenic erectile dysfunction (PED). MATERIALS...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346728

    authors: La Vignera S,Condorelli R,Vicari E,D'Agata R,Calogero AE

    更新日期:2011-11-01 00:00:00

  • Synthetic salmon calcitonin is not diabetogenic in patients with normal or impaired glucose metabolism.

    abstract::The effects of short term administration of 200 MRC U of synthetic salmon calcitonin (sCT) daily on carbohydrate metabolism were investigated in 10 patients with various bone diseases, 3 of whom had type II diabetes mellitus and 3 of whom had impaired glucose tolerance. Blood glucose levels during the nocturnal postab...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350629

    authors: Giustina G,Cerudelli B,Cimino A,Rigosa C,Rotondi A,Radaeli E

    更新日期:1985-02-01 00:00:00

  • A naturally occurring deletion in the SRY promoter region affecting the Sp1 binding site is associated with sex reversal.

    abstract::Male to female sex reversal results from failure of testis development. Mutations in the SRY gene or in other genes involved in the sexual differentiation pathway are considered to cause XY gonadal dysgenesis. The majority of the mutations in the SRY described so far are located within the SRY coding region, mainly in...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347266

    authors: Assumpção JG,Ferraz LF,Benedetti CE,Maciel-Guerra AT,Guerra G Jr,Marques-de-Faria AP,Baptista MT,de Mello MP

    更新日期:2005-07-01 00:00:00

  • Glycometabolic control in acromegalic patients with diabetes: a study of the effects of different treatments for growth hormone excess and for hyperglycemia.

    abstract:BACKGROUND:Diabetes mellitus is frequently observed in patients with acromegaly. Current therapies for acromegaly may impact glucose regulation, influencing insulin sensitivity and secretion. The question whether these therapies modify control and progression of diabetes once present is still open. AIM:Aim of our stud...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/7685

    authors: Cambuli VM,Galdiero M,Mastinu M,Pigliaru F,Auriemma RS,Ciresi A,Pivonello R,Amato M,Giordano C,Mariotti S,Colao A,Baroni MG

    更新日期:2012-02-01 00:00:00

  • Cardiovascular outcome trials and major cardiovascular events: does glucose matter? A systematic review with meta-analysis.

    abstract:PURPOSE:We did a meta-analysis with meta-regression to evaluate the relationship between hemoglobin A1c (A1C) reduction and the primary CV outcome of cardiovascular outcome trials (CVOTs). METHODS:We used a random effects meta-analysis of the 12 CVOTs to quantify the effect of A1C reduction on major cardiovascular eve...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,meta分析

    doi:10.1007/s40618-019-01047-0

    authors: Giugliano D,Chiodini P,Maiorino MI,Bellastella G,Esposito K

    更新日期:2019-10-01 00:00:00

  • Glycated hemoglobin, diabetes mellitus, and cardiovascular risk in a cross-sectional study among She Chinese population.

    abstract:OBJECTIVE:To determine whether glycated hemoglobin (HbA1c) could be used to diagnose Type 2 diabetes mellitus in She Chinese People and to assess the role of HbA1c in the development of cardiovascular disease. RESEARCH DESIGN AND METHODS:An ethnically representative sample of 687 (277 males and 410 females) adults, 20...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.3275/7749

    authors: Lin Y,Xu Y,Chen G,Huang B,Chen Z,Yao L,Chen Z

    更新日期:2012-01-01 00:00:00

  • Graves' disease and Hashimoto's thyroiditis: effects of high doses of antithyroid drugs on thyroid autoantibody levels.

    abstract::We studied the effects of high doses of methimazole (MMI) or propylthiouracil (PTU) on thyroid-stimulating antibody (TSAb), antithyroid microsomal (MCHA) and antithyroglobulin (TGHA) levels in Graves' disease and Hashimoto's thyroiditis. Thirty Graves' hyperthyroid patients were treated for 14 +/- 8 months (mean +/- S...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348107

    authors: Romaldini JH,Werner MC,Rodrigues HF,Teixeira VL,Werner RS,Farah CS,Bromberg N

    更新日期:1986-06-01 00:00:00

  • Thyrotropin receptor-adenylate cyclase system in plasma membranes from normal and diseased human thyroid glands.

    abstract::Thyrotropin binding characteristics and adenylate cyclase (AC) activity of thyroid plasma membranes were studied in 52 tissues from normal and diseased human thyroids. Data from normal glands, Graves' goiters, non toxic multinodular goiters and nodular and perinodular tissue of toxic nodular goiters show the same basa...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350977

    authors: Carayon P,Guibout M,Lissitzky S

    更新日期:1978-10-01 00:00:00