Abstract:
OBJECTIVE:To study the long term risk of cervical and other cancers after treatment for cervical intraepithelial neoplasia. DESIGN:Retrospective cohort study. SETTING:University Hospital, Helsinki, Finland. PARTICIPANTS:7564 women treated for cervical intraepithelial neoplasia during 1974 and 2001 and followed up through the Finnish cancer registry until 2003. MAIN OUTCOME MEASURES:Standardised incidence ratio for cervical cancer and other cancers. RESULTS:During follow-up 22 cases of invasive cervical cancer occurred in women treated for cervical intraepithelial neoplasia (standardised incidence ratio 2.8, 95% confidence interval 1.7 to 4.2). The highest risk was during the second decade (10 cases observed: 3.1, 1.5 to 5.7). The standardised incidence ratio for cervical intraepithelial cancer type 1 was 3.1 (1.4 to 6.2) and for type 2 was 3.7 (0.9 to 10.7). CONCLUSIONS:The risk of cervical cancer in the first 20 years after treatment for cervical intraepithelial neoplasia is higher than in the average population. The risk of smoking related cancers is also increased.
journal_name
BMJjournal_title
BMJ (Clinical research ed.)authors
Kalliala I,Anttila A,Pukkala E,Nieminen Pdoi
10.1136/bmj.38663.459039.7Ckeywords:
subject
Has Abstractpub_date
2005-11-19 00:00:00pages
1183-5issue
7526eissn
0959-8138issn
1756-1833pii
331/7526/1183journal_volume
331pub_type
杂志文章abstract:STUDY QUESTION:What are the long term trends in the total (live births, fetal deaths, and terminations of pregnancy for fetal anomaly) and live birth prevalence of neural tube defects (NTD) in Europe, where many countries have issued recommendations for folic acid supplementation but a policy for mandatory folic acid f...
journal_title:BMJ (Clinical research ed.)
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更新日期:1997-01-04 00:00:00
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更新日期:2007-02-10 00:00:00
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pub_type: 杂志文章
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更新日期:2012-11-05 00:00:00
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doi:10.1136/bmj.306.6883.979
更新日期:1993-04-10 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1136/bmj.315.7111.779
更新日期:1997-09-27 00:00:00
abstract::The Swedish government recently published a report on priorities in health care. It was written by a cross party group of politicians and drew extensively on the views of the public, health professionals, experience of earlier local exercises in priority setting, and research based evidence. It laid down an ethical fr...
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更新日期:1996-03-16 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2002-10-05 00:00:00
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更新日期:2012-10-31 00:00:00
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更新日期:2002-10-26 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2005-04-23 00:00:00
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更新日期:2014-09-10 00:00:00
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更新日期:1995-07-08 00:00:00
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更新日期:2013-10-01 00:00:00
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更新日期:1995-07-29 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1136/bmj.b4353
更新日期:2009-11-11 00:00:00