Risk of cervical and other cancers after treatment of cervical intraepithelial neoplasia: retrospective cohort study.

Abstract:

OBJECTIVE:To study the long term risk of cervical and other cancers after treatment for cervical intraepithelial neoplasia. DESIGN:Retrospective cohort study. SETTING:University Hospital, Helsinki, Finland. PARTICIPANTS:7564 women treated for cervical intraepithelial neoplasia during 1974 and 2001 and followed up through the Finnish cancer registry until 2003. MAIN OUTCOME MEASURES:Standardised incidence ratio for cervical cancer and other cancers. RESULTS:During follow-up 22 cases of invasive cervical cancer occurred in women treated for cervical intraepithelial neoplasia (standardised incidence ratio 2.8, 95% confidence interval 1.7 to 4.2). The highest risk was during the second decade (10 cases observed: 3.1, 1.5 to 5.7). The standardised incidence ratio for cervical intraepithelial cancer type 1 was 3.1 (1.4 to 6.2) and for type 2 was 3.7 (0.9 to 10.7). CONCLUSIONS:The risk of cervical cancer in the first 20 years after treatment for cervical intraepithelial neoplasia is higher than in the average population. The risk of smoking related cancers is also increased.

journal_name

BMJ

authors

Kalliala I,Anttila A,Pukkala E,Nieminen P

doi

10.1136/bmj.38663.459039.7C

keywords:

subject

Has Abstract

pub_date

2005-11-19 00:00:00

pages

1183-5

issue

7526

eissn

0959-8138

issn

1756-1833

pii

331/7526/1183

journal_volume

331

pub_type

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