Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy.

Abstract:

Objective:This study compared the effect of levetiracetam (LEV) as monotherapy to sodium valproate (VPA) as monotherapy on cognitive functions in patients with epilepsy. Methods:This was a comparative prospective study on 50 patients with newly diagnosed epilepsy started on antiseizure medications. Patients were selected from the neurology-outpatient clinics at Minia University Hospital, Minia, Egypt. They were divided into two groups: group treated with LEV and group treated with VPA. All patients were subjected to cognitive function assessment using reaction-time tests, trail-making tests, and Wisconsin card-sorting test before treatment and 3 months after treatment. Results:Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment. Conclusion:Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment.

authors

El Sabaa RM,Hamdi E,Hamdy NA,Sarhan HA

doi

10.2147/NDT.S256117

subject

Has Abstract

pub_date

2020-08-11 00:00:00

pages

1945-1953

eissn

1176-6328

issn

1178-2021

pii

256117

journal_volume

16

pub_type

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