当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > Growth hormone insufficiency in a girl with the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

Growth hormone insufficiency in a girl with the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

Abstract：

:Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited disease which may comprise many endocrine and non-endocrine components. GH insufficiency has not been recognised as a classical manifestation of this syndrome. We describe the case of a girl with APECED, who presented with four endocrine (hypoparathyroidism, Addison's disease, hypothyroidism, gonadal failure) and three non-endocrine components (candidiasis, ectodermal dystrophy and lichen ruber planus). In addition, growth failure was documented beginning at approximately 8 years; bone age was delayed and stimulated GH peaks after clonidine and arginine were 2.2 and 9.2 microg/l, respectively. A partial empty sella was found on a computed tomography scan of the hypothalamic-pituitary region. At 10.5 years rhGH therapy was started and height gain of 26 cm was observed after 2.7 years of treatment. Puberty started at 11.2 years and menarche occurred at 12.7 years. At 13.25 years rhGH therapy was discontinued owing to frequent hypocalcemic crises; serum IGF-1 levels were persistently low in the following years (between 160 and 180 microg/l, normal range for age 250-600 microg/l). The patient attained a final height of 160.8 cm, which was appropriate for her target height. The presence of lichen ruber planus and GH insufficiency probably secondary to empty sella are two unusual findings in patients with APECED.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Franzese A,Valerio G,Di Maio S,Iannucci MP,Bloise A,Tenore A

doi

10.1007/BF03345481

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

66-9

issue

1

eissn

0391-4097

issn

1720-8386

journal_volume

22

pub_type

杂志文章

相关文献

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION文献大全
  • Maternal nutrition, fetal weight, body composition and disease in later life.

    abstract：:Nutritional and hormonal milieu in utero affect fetal growth. Both parties involved have an independent chance, for the occurrence of a developmental error at any stage of their constant developing system. Studies suggest that pregnancy outcome is associated with fetal demand for nutrients and the materno-placental ca...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03345248

    authors： Zadik Z

    更新日期：2003-09-01 00:00:00

  • Metabolic impact of body fat distribution.

    abstract：:Many studies have shown that fat distribution influences metabolism independently of the effects of total body fat stores. The accumulation of fat in the abdominal area, particularly in the visceral fat compartment, seems to be associated with an increased risk to display complications such as insulin resistance, diab...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03344051

    authors： Gasteyger C,Tremblay A

    更新日期：2002-11-01 00:00:00

  • Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines.

    abstract：BACKGROUND:Agents capable of increasing radioiodine concentration by stimulating the sodium/iodide symporter (NIS) expression have been extensively investigated for the treatment of certain well-differentiated breast cancers. AIM:In this study, we analyzed the regulation of the NIS and lactoperoxidase (LPO) gene expre...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346542

    authors： Sponziello M,Scipioni A,Durante C,Verrienti A,Maranghi M,Giacomelli L,Ferretti E,Celano M,Filetti S,Russo D

    更新日期：2010-01-01 00:00:00

  • Principles and clinical applications of liquid chromatography - tandem mass spectrometry for the determination of adrenal and gonadal steroid hormones.

    abstract：:Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample prepa...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.3275/7843

    authors： Kulle AE,Welzel M,Holterhus PM,Riepe FG

    更新日期：2011-10-01 00:00:00

  • Multiple endocrine neoplasia type 2A/localized cutaneous lichen amyloidosis associated with malignant pheochromocytoma and ganglioneuroma.

    abstract：:We hereby present a rare variant of multiple endocrine neoplasia type 2A (MEN2A) associated with a rare skin disease primary cutaneous lichen amyloidosis and discrete malignant pheochromocytoma in both adrenal glands and pancreatic tail, and interestingly accompanied ganglioneuroma located in retroperitoneum in a 34-y...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347557

    authors： Gullu S,Gursoy A,Erdogan MF,Dizbaysak S,Erdogan G,Kamel N

    更新日期：2005-09-01 00:00:00

  • The inductive effects of progestogens on aromatase activity in stromal cells of human uterine endometrium.

    abstract：:Aromatase activity for androstenedione was measured in stromal cells of human uterine endometrium throughout the menstrual cycle. The effect of progestogen on aromatase activity was also examined in the endometrial stromal cells. Aromatase activity tended to be high in the proliferative cells compared to the secretory...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349962

    authors： Yamamoto T,Shiroshita K,Kitawaki J,Okada H

    更新日期：1989-03-01 00:00:00

  • The modulation of glucocorticoid receptor content by 3-O-methyl-D-glucose transport in human mononuclear leukocyte in obesity.

    abstract：:Glucocorticoid receptors (GR) and 3-O-methyl-D glucose (3-O-MG) transport were determined in mononuclear leukocytes (MNL) from 11 abdominal obese subjects, 10 pituitary-dependent Cushing's syndrome (Cushing's disease) and 10 healthy controls. Using a whole-cell competitive binding assay and 3H-dexamethasone as tracer,...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350794

    authors： Güven M,Hatemi H,Taşan E,Altuntaş Y,Ulutin T,Tezcan V,Kanigür-Sultuybek G

    更新日期：1998-11-01 00:00:00

  • EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man.

    abstract：:EP1572 UMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after s.c. administration in neonatal rats. Preliminary data in 2 normal young men s...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345096

    authors： Broglio F,Boutignon F,Benso A,Gottero C,Prodam F,Arvat E,Ghè C,Catapano F,Torsello A,Locatelli V,Muccioli G,Boeglin D,Guerlavais V,Fehrentz JA,Martinez J,Ghigo E,Deghenghi R

    更新日期：2002-09-01 00:00:00

  • Case of an ivory vertebra.

    abstract：:The differential diagnosis of an osteoblastic vertebral lesion (ivory vertebra) includes metastatic prostate cancer, lung cancer, lymphoma, osteosarcoma and Paget's disease. We report a case of a man who was initially diagnosed with Paget's disease on vertebral biopsy. He failed to respond to conventional bisphosphate...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343770

    authors： Basaria S,McCarthy EF,Belzberg AJ,Ball DW

    更新日期：2000-09-01 00:00:00

  • Decrease of thyroid antibodies during pregnancy.

    abstract：:The behavior of serum anti-thyroglobulin (Abs-Tg) and antimicrosomal antibodies (Abs-Mc) was examined during and after normal pregnancies. The antibodies titer decreases as pregnancy progresses; they cross the placenta and are present in the fetal serum. Infants' thyroid function is not affected by this transplacentar...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349385

    authors： D'Armiento M,Salabé H,Vetrano G,Scucchia M,Pachi A

    更新日期：1980-10-01 00:00:00

  • Subclinical hypothyroidism: the state of the art.

    abstract：:Subclinical hypothyroidism (SH) is a common clinical problem, particularly in adulthood and the elderly. Its prevalence is conditioned by several etiological and risk factors. The highest age- and sex-specific rates are in women over 60. SH may be associated with manifestations of mild thyroid failure, which may rever...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03345571

    authors： Arrigo T,Wasniewska M,Crisafulli G,Lombardo F,Messina MF,Rulli I,Salzano G,Valenzise M,Zirilli G,De Luca F

    更新日期：2008-01-01 00:00:00

  • Twenty-four-hour prolactin secretory patterns in women with galactorrhea, normal menses, normal random prolacting levels and abnormal sellar tomograms.

    abstract：:During a systematic study of women with idiopathic galactorrhea, we observed several patients with normal random serum prolactin (PRL) levels and normal menses, but abnormal sellar tomograms characteristic of a pituitary adenoma. To test the hypothesis that these women might have intermittent PRL hypersecretion, we st...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348450

    authors： Kapcala LP,Molitch ME,Arno J,King LW,Reichlin S,Wolpert SM

    更新日期：1984-10-01 00:00:00

  • 17beta-Hydroxysteroid dehydrogenase-3 deficiency: from pregnancy to adolescence.

    abstract：OBJECTIVE:Aim of this study is to report on basal clinical phenotype and follow up after diagnosis, of patients with 17beta-hydroxysteroid-dehydrogenase type 3 (17beta-HSD3) deficiency in Italy. SETTING:Pediatric Endocrine Departments, University Hospitals. PATIENTS:The cases of 5 Italian subjects affected by 17beta-...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345738

    authors： Bertelloni S,Balsamo A,Giordani L,Fischetto R,Russo G,Delvecchio M,Gennari M,Nicoletti A,Maggio MC,Concolino D,Cavallo L,Cicognani A,Chiumello G,Hiort O,Baroncelli GI,Faienza MF

    更新日期：2009-09-01 00:00:00

  • Genotype, phenotype and hormonal levels correlation in non-classical congenital adrenal hyperplasia.

    abstract：:Non-classical congenital adrenal hyperplasia (NCAH) is a morbid condition sustained by the reduced function of one of the enzymes involved in the adrenal steroid biosynthesis pathway, mainly the 21-hydroxylase. Different degrees of enzyme activity impairment determine different clinical pictures, with childhood or pos...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/7410

    authors： Einaudi S,Napolitano E,Restivo F,Motta G,Baldi M,Tuli G,Grosso E,Migone N,Menegatti E,Manieri C

    更新日期：2011-10-01 00:00:00

  • Portal, hepatic and peripheral insulin immunoreactive substances before and after removal of an insulinoma.

    abstract：:Plasma insulin immunoreactivity (IRI) results from high molecular weight substances with insulin immunoreactivity (HWIRI), proinsulin (PI) and insulin (I). Their respective concentrations and percentages of IRI were determined preoperatively in the hepatic and peripheral circulations and after surgery in the latter tw...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350520

    authors： Villaume C,Beck B,Pointel JP,Drouin P,Debry G

    更新日期：1982-09-01 00:00:00

  • Reproducibility and validity of the Italian version of the International Physical Activity Questionnaire in obese and diabetic patients.

    abstract：PURPOSE:Aims of this study were to evaluate the agreement between the short and long versions of the International Physical Activity Questionnaire (IPAQ: Italian versions), their reproducibility (agreement and reliability) and construct validity (relative to pedometry) in a clinical population. METHODS:Ninety patients...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-017-0746-3

    authors： Minetto MA,Motta G,Gorji NE,Lucini D,Biolo G,Pigozzi F,Portincasa P,Maffiuletti NA

    更新日期：2018-03-01 00:00:00

  • Prolactin decrease and shift to a normal-like isoform profile during treatment with quinagolide in a patient affected by an invasive prolactinoma.

    abstract：:Prolactin (PRL) circulates as multiple molecular weight variants: glycosylated phosphorylated, deamidated and sulphated forms. The profiles of the forms, as determined by isoelectrofocusing (IEF), differ in physiological and pathological conditions. The case of a 72-year-old woman affected by an invasive prolactinoma ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350303

    authors： Guido R,Valenti S,Foppiani L,De Martini D,Cossu M,Giusti M

    更新日期：1997-05-01 00:00:00

  • An in vitro procedure for the estimation of thyroid hormone releasing factors in sera of thyrotoxic patients.

    abstract：:LATS containing sera and a number of Graves' disease sera stimulated T4 release from mouse thyroids in vitro as determined by RIA, thus confirming the presence of a thyroid hormone releasing factor in sera of thyrotoxic patients. The pattern of stimulation was similar to that previously shown for TSH in terms of T4 re...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350973

    authors： Maayan ML,Volpert EM,Dawry FP

    更新日期：1978-10-01 00:00:00

  • The association of plasma free amino acids with liver enzymes in Type 2 diabetic patients.

    abstract：BACKGROUND:Elevated γ-glutamyl transpeptidase (GGT) and alanine aminotransferase (ALT) could predict the risk of Type 2 diabetes (T2D), but the reason for their elevation was unclear. GGT and ALT mediated the metabolism of many amino acids (AA). Up to now, it was not investigated whether abnormal AA concentration was a...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/8059

    authors： Chen T,Zhang X,Long Y,Yu H,Ran X,Gao Y,Lu H,Xie X,Chen X,Ren Y,Shi J,Tian H

    更新日期：2012-09-01 00:00:00

  • Modulating effect of leptin on basal and follicle stimulating hormone stimulated steroidogenesis in cultured human lutein granulosa cells.

    abstract：BACKGROUND:In vitro data have shown conflicting results in terms of the effect of leptin on granulosa cells steroidogenesis. AIM:The aim of the present study was to investigate the effect of low and high doses of leptin on basal and FSH-induced steroids secretion by human luteinized granulosa cells in culture. MATERI...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346478

    authors： Karamouti M,Kollia P,Kallitsaris A,Vamvakopoulos N,Kollios G,Messinis IE

    更新日期：2009-05-01 00:00:00

  • Regional distribution of nuclear T3 receptors in rat brain and evidence for preferential localization in neurons.

    abstract：:We examined the distribution of nuclear T3 in mature rat brain with the aim of determining specific targets of thyroid hormones within this tissue. Saturation experiments, performed in 9 different structures of the brain and in 4 parts of the cortex, revealed the presence of a single class of binding sites with a mean...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348511

    authors： Ruel J,Faure R,Dussault JH

    更新日期：1985-08-01 00:00:00

  • Prevalence of cardiovascular risk factors in male and female patients with primary hyperparathyroidism.

    abstract：OBJECTIVE:To investigate the prevalence of cardiovascular risk factors in patients with primary hyperparathyroidism (PHPT) and to determine if they are gender specific. METHODS:This was a retrospective case control study. Three hundred and sixty-three men and women with PHPT and 363 age-, sex-, and body mass index (BM...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/7861

    authors： Han D,Trooskin S,Wang X

    更新日期：2012-06-01 00:00:00

  • Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhood.

    abstract：:Ghrelin, a natural GH secretagogue, exerts remarkable endocrine and non-endocrine activities such as orexigenic effect and modulation of the endocrine and metabolic response to variations in energy balance. Ghrelin levels have been reported to be negatively associated to insulin secretion, enhanced in anorexia and red...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03344026

    authors： Bellone S,Rapa A,Vivenza D,Castellino N,Petri A,Bellone J,Me E,Broglio F,Prodam F,Ghigo E,Bona G

    更新日期：2002-05-01 00:00:00

  • The use of ultrasensitive thyroglobulin assays reduces but does not abolish the need for TSH stimulation in patients with differentiated thyroid carcinoma.

    abstract：:Measurement of serum Tg using ultrasensitive assays is proposed to replace TSH-stimulated Tg measurement in the follow-up of differentiated thyroid cancer (DTC). Aim of our study was to verify this possibility using two ultrasensitive Tg assays. We selected 215 DTC patients with undetectable (<1 ng/ml) basal serum Tg ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/7571

    authors： Castagna MG,Tala Jury HP,Cipri C,Belardini V,Fioravanti C,Pasqui L,Sestini F,Theodoropoulou A,Pacini F

    更新日期：2011-09-01 00:00:00

  • Structure-function correlations of growth hormone or/and prolactin-producing pituitary adenomas: an in vitro study with the reverse hemolytic plaque assay.

    abstract：:The purpose of this study was to detect in vitro growth hormone (GH) and prolactin (PRL) secretion from adenomas clinically associated with GH or PRL hypersecretion. The reverse hemolytic plaque assay (RHPA) was applied in order to reveal possible differences among various morphologic adenoma types, and to examine the...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343628

    authors： Thodou E,Kontogeorgos G,Kyrodimou E,Salla H,Ramyar L,Vamvassakis E,Piaditis G,Anagnostopoulos N,Tzanis S,Levedis A,Rologis D,Asa SL

    更新日期：1999-10-01 00:00:00

  • Growth hormone therapy in a poorly growing child with hypophosphatemic rickets.

    abstract：:We treated a 10 6/12 year old prepubertal male with hypophosphatemic rickets, who was growing poorly despite appropriate treatment with calcitriol and phosphate, with exogenous growth hormone (for an initial trial period of 4 months, followed by 14 months of continuous treatment at a dose of 4 IU three times weekly) e...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349633

    authors： Lanes R,Harrison HE

    更新日期：1990-11-01 00:00:00

  • Lack of dissociation of prolactin responses to thyrotropin releasing hormone and metoclopramide in chronic alcoholic men.

    abstract：:Prolactin, growth hormone and thyroid stimulating hormone responses to thyrotropin releasing hormone (TRH) and metoclopramide were determined in 12 alcoholic men with biopsy proven liver disease and were compared to those of 8 age matched normal controls. All subjects were challenged with TRH (400 micrograms) and meto...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350515

    authors： Van Thiel DH,Gavaler JS,Sanghvi A

    更新日期：1982-09-01 00:00:00

  • Sexual function in young women with type 1 diabetes: the METRO study.

    abstract：PURPOSE:The aim of this study was to evaluate the prevalence and risk factors associated with female sexual dysfunction (FSD) in young women with type 1 diabetes treated with different intensive insulin regimens. METHODS:Type 1 diabetic women aged 18-35 years were included in this study if they had stable couple relat...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章

    doi：10.1007/s40618-016-0542-5

    authors： Maiorino MI,Bellastella G,Castaldo F,Petrizzo M,Giugliano D,Esposito K

    更新日期：2017-02-01 00:00:00

  • Decreased IGF-I bioavailability after ethanol abuse in alcoholics: partial restitution after short-term abstinence.

    abstract：:IGF-I stimulates protein synthesis, lowers blood glucose, and affects cell differentiation. The main production site of IGF-I is the liver. One of its binding proteins, IGFBP-1, is also produced by the liver. It is well known that ethanol affects the function of the human liver. Long-term alcohol abuse may therefore n...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343879

    authors： Röjdmark S,Brismar K

    更新日期：2001-07-01 00:00:00

  • Hexarelin-induced growth hormone response in short stature. Comparison with growth hormone-releasing hormone plus pyridostigmine and arginine plus estrogen.

    abstract：UNLABELLED:Hexarelin (HEX) is a synthetic hexapeptide with strong GH-stimulating activity. We evaluated GH response (expressed as maximum value after stimulus [Cmax] and as area under the curve [AUC]) to HEX at the doses of 1 microg/kg i.v. (HEX 1) and 2 microg/kg i.v. (HEX 2), in comparison with the responses to GHRH ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343574

    authors： Guzzaloni G,Grugni G,Morabito F

    更新日期：1999-05-01 00:00:00