Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA-96.


:Long noncoding RNAs (lncRNAs) are emerging as key regulators in cancer initiation and progression. TP53TG1 is a recently identified lncRNA and several studies have shown that TP53TG1 may play the role of tumor suppressor gene or oncogene in different tumors. Nevertheless, the involvement of TP53TG1 in carcinogenesis of pancreatic ductal adenocarcinoma (PDAC) has not been characterized. In our studies, we identified that TP53TG1 was highly expressed in PDAC and was a novel regulator of PDAC development. Knockdown of TP53TG1 inhibited proliferation, induced apoptosis, and decreased migration and invasion in PDAC cells, whereas enhanced expression of TP53TG1 had the opposite effects. Mechanistically, TP53TG1 could directly bind to microRNA (miR)-96 and effectively function as a sponge for miR-96, thus antagonizing the functions of miR-96 and leading to derepression of its endogenous target KRAS, which is a core oncogene in the initiation and maintenance of PDAC. Taken together, these observations imply that TP53TG1 contributes to the growth and progression of PDAC by acting as a competing endogenous RNA (ceRNA) to competitively bind to miR-96 and regulate KRAS expression, which highlights the importance of the complicated miRNA-lncRNA network in modulating the progression of PDAC.


Cancer Sci


Cancer science


Zhang Y,Yang H,Du Y,Liu P,Zhang J,Li Y,Shen H,Xing L,Xue X,Chen J,Zhang X




Has Abstract


2019-09-01 00:00:00












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    更新日期:2012-05-01 00:00:00

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    abstract::Epigenetic regulation in hematopoiesis has been a field of rapid expansion. Genome-wide analyses have revealed, and will continue to identify genetic alterations in epigenetic genes that are present in various types of hematopoietic neoplasms. Development of new mouse models for individual epigenetic modifiers has rev...

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    authors: Yoshida N,Omoto Y,Inoue A,Eguchi H,Kobayashi Y,Kurosumi M,Saji S,Suemasu K,Okazaki T,Nakachi K,Fujita T,Hayashi S

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    abstract::Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers. OSCC generally has a poor prognosis due to its tendency towards local invasion and subsequent metastasis, which is mediated by multiple proteolytic enzymes and angiogenesis. The purpose of this study was to evaluate the anti-cancer ef...

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    更新日期:2010-03-01 00:00:00

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    authors: Chaiyarit P,Ma N,Hiraku Y,Pinlaor S,Yongvanit P,Jintakanon D,Murata M,Oikawa S,Kawanishi S

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    authors: Sugai T,Eizuka M,Takahashi Y,Fukagawa T,Habano W,Yamamoto E,Akasaka R,Otuska K,Matsumoto T,Suzuki H

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  • Stage IV marginal zone B-cell lymphoma--prognostic factors and the role of rituximab: Consortium for Improving Survival of Lymphoma (CISL) study.

    abstract::Stage IV marginal zone B-cell lymphomas (MZL) are detected in more than 25% of lymphoma patients. In this study, we conducted retrospective analyses of specific cases of stage IV MZL in order to assess their clinical features, as well as the treatments and prognoses of these cases. A total of 94 patients with histolog...

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    pub_type: 杂志文章


    authors: Ge XS,Ma HJ,Zheng XH,Ruan HL,Liao XY,Xue WQ,Chen YB,Zhang Y,Jia WH

    更新日期:2013-12-01 00:00:00