Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA-96.

abstract：:Recent discoveries have revealed that human cancer involves aberrant epigenetic alterations. We and others have previously shown that the histone methyltransferase EZH2, the catalytic subunit of polycomb repressive complex 2 (PRC2), is frequently overexpressed in non-small-cell lung cancer (NSCLC) and that an EZH2 inh...

journal_title：Cancer science

authors： Takashina T,Kinoshita I,Kikuchi J,Shimizu Y,Sakakibara-Konishi J,Oizumi S,Nishimura M,Dosaka-Akita H

更新日期：2016-07-01 00:00:00

abstract：:Vasculogenic mimicry (VM) formation by cancer cells is known to play a crucial role in tumor progression, but its detailed mechanism is unclear. In the present study, we focused on integrin β1 (ITGB1) and assessed the role of ITGB1 in VM formation. We used in vitro methods to seed cancer cells on Matrigel to evaluate ...

journal_title：Cancer science

authors： Kawahara R,Niwa Y,Simizu S

更新日期：2018-08-01 00:00:00

abstract：:Glypican-3 (GPC3) is a heparan sulfate proteoglycan that is bound to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor, and glypicans can regulate the activity of a wide variety of growth and survival factors. We report here that GPC3 was expressed in clear cell carcinoma of the ovary, and not in other ...

journal_title：Cancer science

authors： Umezu T,Shibata K,Shimaoka M,Kajiyama H,Yamamoto E,Ino K,Nawa A,Senga T,Kikkawa F

更新日期：2010-01-01 00:00:00

abstract：:Angiogenesis, neovascularization from pre-existing vasculature, is necessary to supply oxygen and nutrition for tumor growth in both primary and distant organs. It consists of sprouting and non-sprouting (the enlargement, splitting, and fusion of pre-existing vessels) processes, and both can occur concurrently. Growth...

journal_title：Cancer science

authors： Yano S,Nishioka Y,Goto H,Sone S

更新日期：2003-06-01 00:00:00

abstract：:CADM1, a member of the immunoglobulin superfamily cell adhesion molecule, acts as a tumor suppressor in a variety of human cancers. CADM1 is also ectopically expressed in adult T-cell leukemia (ATL), conferring an invasive phenotype characteristic to ATL. Therefore, CADM1 plays dual roles in human oncogenesis. Here, w...

journal_title：Cancer science

authors： Kikuchi S,Iwai M,Sakurai-Yageta M,Tsuboi Y,Ito T,Maruyama T,Tsuda H,Kanai Y,Onizuka M,Sato Y,Murakami Y

更新日期：2012-06-01 00:00:00

abstract：:Inotuzumab ozogamicin (CMC-544), an antibody-targeted chemotherapeutic agent composed of an anti-CD22 antibody conjugated to calicheamicin, a potent cytotoxic antibiotic, specifically targets the CD22 antigen present in >90% of B-lymphoid malignancies, rendering it useful for treating patients with B-cell non-Hodgkin ...

journal_title：Cancer science

authors： Ogura M,Tobinai K,Hatake K,Uchida T,Kasai M,Oyama T,Suzuki T,Kobayashi Y,Watanabe T,Azuma T,Mori M,Terui Y,Yokoyama M,Mishima Y,Takahashi S,Ono C,Ohata J

更新日期：2010-08-01 00:00:00

abstract：:We recently reported that compound 20d (comp.20d), a novel pyrrolo[3, 2-d]pyrimidine derivative, is a potent and selective inhibitor of tumor angiogenesis-related kinases, including vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR). In this study, we show that comp...

journal_title：Cancer science

authors： Awazu Y,Mizutani A,Nagase Y,Iwata H,Oguro Y,Miki H,Imamura S,Hori A

更新日期：2012-05-01 00:00:00

abstract：:Overexpression of "stemness gene"Bmi-1 has been identified in some solid tumors. We investigated Bmi-1 expression in hepatocellular carcinoma (HCC) and ATP-binding cassette transporter B1 (ABCB1) as a new potential target for Bmi-1. Bmi-1 was highly expressed in HCC cell lines and the most well differentiated cell lin...

journal_title：Cancer science

authors： Effendi K,Mori T,Komuta M,Masugi Y,Du W,Sakamoto M

更新日期：2010-03-01 00:00:00

abstract：:Epigenetic regulation in hematopoiesis has been a field of rapid expansion. Genome-wide analyses have revealed, and will continue to identify genetic alterations in epigenetic genes that are present in various types of hematopoietic neoplasms. Development of new mouse models for individual epigenetic modifiers has rev...

journal_title：Cancer science

authors： Goyama S,Kitamura T

更新日期：2017-04-01 00:00:00

abstract：:Estrogen receptor (ER)-positive breast cancer is a distinct subpopulation of breast cancer exhibiting a high response rate to endocrine therapy. However, not all ER-positive patients respond to the therapy, and a subgrouping of ER-positive patients based on the physiology of estrogen signaling is expected to be useful...

journal_title：Cancer science

authors： Yoshida N,Omoto Y,Inoue A,Eguchi H,Kobayashi Y,Kurosumi M,Saji S,Suemasu K,Okazaki T,Nakachi K,Fujita T,Hayashi S

更新日期：2004-06-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers. OSCC generally has a poor prognosis due to its tendency towards local invasion and subsequent metastasis, which is mediated by multiple proteolytic enzymes and angiogenesis. The purpose of this study was to evaluate the anti-cancer ef...

journal_title：Cancer science

authors： Myoung H,Hong SP,Yun PY,Lee JH,Kim MJ

更新日期：2003-02-01 00:00:00

abstract：:Proinflammatory cytokines and growth factors have been thought to play crucial roles in the pathology of acute myelogenous leukemia (AML) by supporting the proliferation and survival of AML cells in an autocrine and paracrine manner, although further elucidation is required. JTE-607 was originally identified as a mult...

journal_title：Cancer science

authors： Tajima N,Fukui K,Uesato N,Maruhashi J,Yoshida T,Watanabe Y,Tojo A

更新日期：2010-03-01 00:00:00

abstract：:Tumor cell targeting of drug carriers is a promising strategy and uses the attachment of various ligands to enhance the therapeutic potential of chemotherapy agents. Folic acid is a high-affinity ligand for folate receptor, which is a functional tumor-specific receptor. The transforming growth factor (TGF)-β type I re...

journal_title：Cancer science

authors： Taniguchi Y,Kawano K,Minowa T,Sugino T,Shimojo Y,Maitani Y

更新日期：2010-10-01 00:00:00

abstract：:Ten novel human pancreatic carcinoma cell lines (Sui65 through Sui74) were established from a transplantable pancreatic carcinoma cell line. All the cell lines resembled the original clinical carcinoma in terms of the morphological and biological features, presenting with genetic alterations such as point mutations of...

journal_title：Cancer science

authors： Yanagihara K,Takigahira M,Tanaka H,Arao T,Aoyagi Y,Oda T,Ochiai A,Nishio K

更新日期：2008-09-01 00:00:00

abstract：:Autophagy plays a critical role in tumorigenesis, but how autophagy contributes to cancer cells' responses to chemotherapeutics remains controversial. To investigate the roles of autophagy in malignant gliomas, we used CRISPR/CAS9 to knock out the ATG5 gene, which is essential for autophagosome formation, in tumor cel...

journal_title：Cancer science

authors： Vu HT,Kobayashi M,Hegazy AM,Tadokoro Y,Ueno M,Kasahara A,Takase Y,Nomura N,Peng H,Ito C,Ino Y,Todo T,Nakada M,Hirao A

更新日期：2018-08-01 00:00:00

abstract：:The aim of this study was to elucidate differences in the histological features of rectal cancer between patients treated with preoperative chemoradiotherapy and those treated with preoperative chemotherapy. Area of residual tumor (ART) was also evaluated for its utility as a potential prognostic marker between them. ...

journal_title：Cancer science

authors： Sakuyama N,Kojima M,Kawano S,Matsuda Y,Mino-Kenudson M,Ochiai A,Ito M

更新日期：2018-03-01 00:00:00

abstract：:Arsenic trioxide, As(2)O(3) (ATO), has been established to be an effective agent for treating acute promyelocytic leukemia, but its effect on solid tumors has not been fully explored. In the present study in a murine xenograft system, we found that ATO significantly inhibited tumor growth of the inoculated human hepat...

journal_title：Cancer science

authors： Kito M,Matsumoto K,Wada N,Sera K,Futatsugawa S,Naoe T,Nozawa Y,Akao Y

更新日期：2003-11-01 00:00:00

abstract：:Previously we reported that benzyl isothiocyanate (BITC) strongly enhanced rat urinary bladder carcinogenesis after initiation with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), while potently inhibiting BBN-induction of lesions when given simultaneously with the carcinogen. In the present experiment, the effects of si...

journal_title：Cancer science

authors： Okazaki K,Umemura T,Imazawa T,Nishikawa A,Masegi T,Hirose M

更新日期：2003-11-01 00:00:00

abstract：:Immunotoxins are Ab-cytotoxin chimeric molecules with mighty cytotoxicity. Programmed cell death 1-ligand 1 (PD-L1), is a transmembrane protein expressed mainly in inflammatory tumor tissues and plays a pivotal role in immune escape and tumor progression. Although PD-L1 immune checkpoint therapy has been successful in...

journal_title：Cancer science

authors： Zhang C,Xiong J,Lan Y,Wu J,Wang C,Huang Z,Lin J,Xie J

更新日期：2020-09-01 00:00:00

abstract：:10-Hydroxycamptothecin (HCPT) elicits strong anti-cancer effects and is less toxic than camptothecin (CPT), making it widely used in recent clinical trials. However, its low solubility limits its application as an effective anti-cancer therapy. In the present study we investigate the hypothesis that the unique water d...

journal_title：Cancer science

authors： Zhang G,Ding L,Renegar R,Wang X,Lu Q,Huo S,Chen YH

更新日期：2011-06-01 00:00:00

abstract：:Intratumoral hypoxic cells are more resistant to radiotherapy due to a reduction in lifespan of DNA-damaging free radicals and augmentation of post-irradiation molecular restoration. SirT1, a member of the mammalian sirtuin family, deacetylates various transcription factors to trigger cell defense and survival in resp...

journal_title：Cancer science

authors： Xie Y,Zhang J,Ye S,He M,Ren R,Yuan D,Shao C

更新日期：2012-07-01 00:00:00

abstract：:Fas ligand (CD95L/APO-1) is considered as a potent anti-tumor agent due to its mediated cell death properties. We have designed a polymeric microencapsulation system, which encapsulates soluble FasL secreting cells. The encapsulated cells continuously release soluble FasL (sFasL) at the tumor site, while the device pr...

journal_title：Cancer science

authors： Goren A,Gilert A,Meyron-Holtz E,Melamed D,Machluf M

更新日期：2012-01-01 00:00:00

abstract：:Oral lichen planus (OLP) is a chronic inflammatory disease, which has been clinically associated with development to oral cancer. A double immunofluorescence labeling study found that 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) accumulated in oral epithelium in OLP and oral squamous cell carcinoma...

journal_title：Cancer science

authors： Chaiyarit P,Ma N,Hiraku Y,Pinlaor S,Yongvanit P,Jintakanon D,Murata M,Oikawa S,Kawanishi S

更新日期：2005-09-01 00:00:00

abstract：:To understand the molecular mechanism that underlies the role of various prominent signal pathways in hepatocellular carcinoma (HCC) metastasis, a human signal transduction oligonucleotide microarray analysis was carried out in cultured HCC cell models with increasing spontaneous metastatic potential (MHCC97L, MHCC97H...

journal_title：Cancer science

authors： Guo K,Liu Y,Zhou H,Dai Z,Zhang J,Sun R,Chen J,Sun Q,Lu W,Kang X,Chen P

更新日期：2008-03-01 00:00:00

abstract：:Telomeres protect chromosome ends from being recognized as DNA double-strand breaks. Telomere shortening, which occurs due to incomplete replication of DNA termini, limits the proliferative capacity of human somatic cells and contributes as a barrier to carcinogenesis. In most human cancer cells, telomerase maintains ...

journal_title：Cancer science

authors： Muramatsu Y,Ohishi T,Sakamoto M,Tsuruo T,Seimiya H

更新日期：2007-06-01 00:00:00

abstract：:Despite receiving rituximab-combined chemotherapy, follicular lymphoma (FL) patients often suffer tumor recurrence and understand that the cause of relapse in FL would thus significantly ameliorate the tumor therapeutics. In the present study, we show that TRA-1-60-expressing cells are a unique population in FL, conve...

journal_title：Cancer science

authors： Takata K,Saito K,Maruyama S,Miyata-Takata T,Iioka H,Okuda S,Ling Y,Karube K,Miki Y,Maeda Y,Yoshino T,Steidl C,Kondo E

更新日期：2019-01-01 00:00:00

abstract：:Emerging evidence indicates that small RNAs, including microRNAs (miRNAs) and their isoforms (isomiRs), and transfer RNA fragments (tRFs), are differently expressed in breast cancer (BC) and can be detected in blood circulation. Circulating small RNAs and small RNAs in extracellular vesicles (EVs) have emerged as idea...

journal_title：Cancer science

authors： Koi Y,Tsutani Y,Nishiyama Y,Ueda D,Ibuki Y,Sasada S,Akita T,Masumoto N,Kadoya T,Yamamoto Y,Takahashi RU,Tanaka J,Okada M,Tahara H

更新日期：2020-06-01 00:00:00

abstract：:Tumor tissue consists of a heterogeneous cell population. The allelic imbalance (AI) ratio, determined in isolated tumor glands, is a good index of tumor heterogeneity. However, associations of the patterns of AI and microsatellite instability (MSI) development, observed in most cases of colorectal cancer (CRC), with ...

journal_title：Cancer science

authors： Sugai T,Eizuka M,Takahashi Y,Fukagawa T,Habano W,Yamamoto E,Akasaka R,Otuska K,Matsumoto T,Suzuki H

更新日期：2017-03-01 00:00:00

abstract：:Stage IV marginal zone B-cell lymphomas (MZL) are detected in more than 25% of lymphoma patients. In this study, we conducted retrospective analyses of specific cases of stage IV MZL in order to assess their clinical features, as well as the treatments and prognoses of these cases. A total of 94 patients with histolog...

journal_title：Cancer science

authors： Oh SY,Kim WS,Kim JS,Kim SJ,Lee S,Lee DH,Won JH,Hwang IG,Kim MK,Lee SI,Chae YS,Yang DH,Kang HJ,Choi CW,Park J,Kim HJ,Kwon JH,Lee HS,Lee GW,Eom HS,Kwak JY,Suh C,Kim HJ

更新日期：2010-11-01 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) have been recently found to be pervasively transcribed in the genome and critical regulators of the epigenome. HOTAIR, as a well-known LncRNA, has been found to play important roles in several tumors. Herein, the clinical application value and biological functions of HOTAIR were focused ...

journal_title：Cancer science

authors： Ge XS,Ma HJ,Zheng XH,Ruan HL,Liao XY,Xue WQ,Chen YB,Zhang Y,Jia WH

更新日期：2013-12-01 00:00:00