Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO1) promoter DNA in pancreatic cancer.

abstract：:Systemic administration of drugs into the blood circulation is standard treatment for prevention of metastasis. However, systemic delivery cannot maintain sufficiently high concentrations of anticancer drugs in lymph nodes (LN). Here, we show that giving cisplatin (CDDP) using a lymphatic drug delivery system (LDDS) h...

journal_title：Cancer science

authors： Tada A,Horie S,Mori S,Kodama T

更新日期：2017-11-01 00:00:00

abstract：:We conducted a multicenter retrospective analysis to evaluate the efficacy of systemic chemotherapy for unresectable combined hepatocellular and cholangiocarcinoma. We enrolled 36 patients with pathologically proven, unresectable combined hepatocellular and cholangiocarcinoma treated with systemic chemotherapy. The lo...

journal_title：Cancer science

authors： Kobayashi S,Terashima T,Shiba S,Yoshida Y,Yamada I,Iwadou S,Horiguchi S,Takahashi H,Suzuki E,Moriguchi M,Tsuji K,Otsuka T,Asagi A,Kojima Y,Takada R,Morizane C,Mizuno N,Ikeda M,Ueno M,Furuse J

更新日期：2018-08-01 00:00:00

abstract：:It has been well established that microRNA (miR)-143 is downregulated in human bladder cancer (BC). Recent precision medicine has shown that mutations in BC are frequently observed in FGFR3, RAS and PIK3CA genes, all of which correlate with RAS signaling networks. We have previously shown that miR-143 suppresses cell ...

journal_title：Cancer science

authors： Tsujino T,Sugito N,Taniguchi K,Honda R,Komura K,Yoshikawa Y,Takai T,Minami K,Kuranaga Y,Shinohara H,Tokumaru Y,Heishima K,Inamoto T,Azuma H,Akao Y

更新日期：2019-07-01 00:00:00

abstract：:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported to enhance proliferation and invasion in various cancers. The role of IMP3 on neuroblastoma (NB) is unknown. We aimed to clarify the prognostic significance of IMP3 expression in patients with NB. By microarray analysis, high IMP3 expression...

journal_title：Cancer science

authors： Chen ST,Jeng YM,Chang CC,Chang HH,Huang MC,Juan HF,Hsu CH,Lee H,Liao YF,Lee YL,Hsu WM,Lai HS

更新日期：2011-12-01 00:00:00

abstract：:Despite advances in the development of human papillomavirus (HPV) prophylactic vaccines, little progress has been made in the field of therapeutic vaccines in recent years. In the present study, we found a significant accumulation of immature myeloid cells (ImC) in large TC-1 tumors and demonstrated that a HPV therape...

journal_title：Cancer science

authors： Song X,Ye D,Liu B,Cui J,Zhao X,Yi L,Liang J,Song J,Zhang Z,Zhao Q

更新日期：2009-02-01 00:00:00

abstract：:Death-associated protein (DAP) kinase is a pro-apoptotic serine/threonine kinase with a death domain, which is involved in apoptosis induced by interferon-gamma, tumor necrosis factor-alpha, and Fas ligand. Down-regulation of DAP kinase gene expression by hypermethylation of its promoter region might result in resista...

journal_title：Cancer science

authors： Nakatsuka S,Takakuwa T,Tomita Y,Hoshida Y,Nishiu M,Yamaguchi M,Nishii K,Yang WI,Aozasa K

更新日期：2003-01-01 00:00:00

abstract：:Arsenic trioxide (ATO) is of limited therapeutic benefit for the treatment of solid tumors. Genistein exhibits anticancer and pro-oxidant activities, making it a potential candidate to enhance the efficacy of ATO whose cytotoxicity is oxidation-sensitive. This study sought to determine whether genistein synergizes wit...

journal_title：Cancer science

authors： Jiang H,Ma Y,Chen X,Pan S,Sun B,Krissansen GW,Sun X

更新日期：2010-04-01 00:00:00

abstract：:Tumor tissue consists of a heterogeneous cell population. The allelic imbalance (AI) ratio, determined in isolated tumor glands, is a good index of tumor heterogeneity. However, associations of the patterns of AI and microsatellite instability (MSI) development, observed in most cases of colorectal cancer (CRC), with ...

journal_title：Cancer science

authors： Sugai T,Eizuka M,Takahashi Y,Fukagawa T,Habano W,Yamamoto E,Akasaka R,Otuska K,Matsumoto T,Suzuki H

更新日期：2017-03-01 00:00:00

abstract：:While smoking has consistently been shown to be related to increased risk of colorectal adenomas, few studies have addressed the association between smoking and site-specific colorectal adenomas. The reported association between alcohol use and colorectal adenomas has been inconsistent. We evaluated risks of adenomas ...

journal_title：Cancer science

authors： Toyomura K,Yamaguchi K,Kawamoto H,Tabata S,Shimizu E,Mineshita M,Ogawa S,Lee KY,Kono S

更新日期：2004-01-01 00:00:00

abstract：:Asbestos is a proven human carcinogen. Asbestos-related diseases (ARDs) typically comprise lung cancer, malignant mesothelioma, asbestosis, pleural plaques, thickening and effusion. International organizations, notably the World Health Organization and the International Labour Organization, have repeatedly declared th...

journal_title：Cancer science

authors： Park EK,Takahashi K,Jiang Y,Movahed M,Kameda T

更新日期：2012-10-01 00:00:00

abstract：:Sequential changes in the phenotype of prostatic lesions and the impact of additional carcinogen treatment or castration on development and progression of prostate cancers were examined in probasin/simian virus 40 (SV40) T antigen transgenic (TG) rats. Non-invasive prostate adenocarcinomas were evident in all lobes at...

journal_title：Cancer science

authors： Cho YM,Takahashi S,Asamoto M,Suzuki S,Inaguma S,Hokaiwado N,Shirai T

更新日期：2003-02-01 00:00:00

abstract：:Laminin γ2 (Lmγ2) chain, a subunit of laminin-332, is a typical molecular marker of invading cancer cells, and its expression correlates with poor prognosis of cancer patients. It was previously found that forced expression of Lmγ2 in cancer cells promotes their invasive growth in nude mice. However, the mechanism of ...

journal_title：Cancer science

authors： Sato H,Oyanagi J,Komiya E,Ogawa T,Higashi S,Miyazaki K

更新日期：2014-02-01 00:00:00

abstract：:The extracellular-signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase signaling pathway plays an important role in various cellular responses, including cell proliferation, cell differentiation and cell survival. Recent studies have identified a number of Ras/ERK signaling-related proteins, such as sc...

journal_title：Cancer science

authors： Torii S,Yamamoto T,Tsuchiya Y,Nishida E

更新日期：2006-08-01 00:00:00

abstract：:Occupational asbestos exposure occurs in many workplaces and is a well-known cause of mesothelioma and lung cancer. However, the association between nonoccupational asbestos exposure and those diseases is not clearly described. The aim of this study was to investigate cause-specific mortality among the residents of Am...

journal_title：Cancer science

authors： Zha L,Kitamura Y,Kitamura T,Liu R,Shima M,Kurumatani N,Nakaya T,Goji J,Sobue T

更新日期：2019-03-01 00:00:00

abstract：:We conducted a retrospective, nationwide multicenter study to evaluate the clinical outcomes of proton beam therapy for bone sarcomas of the skull base and spine in Japan. Eligibility criteria included: (i) histologically proven bone sarcomas of the skull base or spine; (ii) no metastases; (iii) ≥20 years of age; and ...

journal_title：Cancer science

authors： Demizu Y,Mizumoto M,Onoe T,Nakamura N,Kikuchi Y,Shibata T,Okimoto T,Sakurai H,Akimoto T,Ono K,Daimon T,Murayama S

更新日期：2017-05-01 00:00:00

abstract：:CIC/Capicua is an HMG-box transcription factor that is well conserved during evolution. CIC recognizes the T(G/C)AATG(A/G)A sequence and represses its target genes, such as PEA3 family genes. The receptor tyrosine kinase/RAS/MAPK signals downregulate CIC and relieves CIC's target genes from the transrepressional activ...

journal_title：Cancer science

authors： Tanaka M,Yoshimoto T,Nakamura T

更新日期：2017-12-01 00:00:00

abstract：:Mutant selective epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such as rociletinib and AZD9291, are effective for tumors with T790M secondary mutation that become refractory to first-generation EGFR-TKI. However, acquired resistance to these prospective drugs is anticipated considering the h...

journal_title：Cancer science

authors： Mizuuchi H,Suda K,Murakami I,Sakai K,Sato K,Kobayashi Y,Shimoji M,Chiba M,Sesumi Y,Tomizawa K,Takemoto T,Sekido Y,Nishio K,Mitsudomi T

更新日期：2016-04-01 00:00:00

abstract：:Mouse thymus-leukemia antigens (TL) are aberrantly expressed on T lymphomas in C57BL/6 (B6) and C3H/He (C3H) mice, while they are not expressed on normal T lymphocytes in these strains. When N-butyl-N-nitrosourea (NBU), a chemical carcinogen, was administered orally to B6 and C3H strains, lymphoma development was slow...

journal_title：Cancer science

authors： Tsujimura K,Obata Y,Matsudaira Y,Ozeki S,Taguchi O,Nishida K,Okanami Y,Akatsuka Y,Kuzushima K,Takahashi T

更新日期：2004-11-01 00:00:00

abstract：:Epidermal growth factor (EGF) gene single-nucleotide polymorphism (SNP) is associated with an increased risk of hepatic tumors. The study aimed to elucidate the impact of EGF SNP and EGF receptor (EGFR) expression on the recurrence of hepatocellular carcinoma (HCC) after hepatectomy. To examine the impact of EGF SNP a...

journal_title：Cancer science

authors： Yoshiya S,Fujimoto Y,Bekki Y,Konishi H,Yamashita Y,Ikegami T,Yoshizumi T,Shirabe K,Oda Y,Maehara Y

更新日期：2014-06-01 00:00:00

abstract：:The mdm2 and mdmx oncogenes play essential yet nonredundant roles in synergistic inactivatiosn of p53. However, the biochemical mechanism by which Mdmx synergizes with Mdm2 to inhibit p53 function remains obscure. Here we demonstrate that, using nonphosphorylatable mutants of Mdmx, the cooperative inhibition of p53 by...

journal_title：Cancer science

authors： Ohtsubo C,Shiokawa D,Kodama M,Gaiddon C,Nakagama H,Jochemsen AG,Taya Y,Okamoto K

更新日期：2009-07-01 00:00:00

abstract：:In spite of the clinical importance of prostate cancer (PCa) bone metastasis, the precise mechanisms for the directed migration of malignant cells remain unclear. In the present study, the expression of CXCR6 in human PCa and benign prostatic hyperplasia samples, and the expression of CXCL16 in human osseous tissues w...

journal_title：Cancer science

authors： Hu W,Zhen X,Xiong B,Wang B,Zhang W,Zhou W

更新日期：2008-07-01 00:00:00

abstract：:Lung cancer patients with human immunodeficiency virus (HIV) have a poorer prognosis than do patients without HIV infection. HIV1 Tat is a secreted viral protein that penetrates the plasma membrane and interacts with a number of proteins in non-HIV-infected cells. The loss of function of Tat-interacting protein 30 (TI...

journal_title：Cancer science

authors： Liu YP,Chen CH,Yen CH,Tung CW,Chen CJ,Chen YA,Huang MS

更新日期：2018-10-01 00:00:00

abstract：:TP53 alterations are frequent relapse-acquired mutations in childhood acute lymphoblastic leukemia (ALL). The present study evaluated the clinical significance of relapsed childhood ALL in Taiwan. Diagnostic and/or relapsed bone marrow or peripheral blood was obtained from 111 children with relapsed ALL who were initi...

journal_title：Cancer science

authors： Yu CH,Chang WT,Jou ST,Lin TK,Chang YH,Lin CY,Lin KH,Lu MY,Chen SH,Wu KH,Wang SC,Chang HH,Su YN,Hung CC,Lin DT,Chen HY,Yang YL

更新日期：2020-01-01 00:00:00

abstract：:This study aimed to analyze the association between driver mutations and predictive markers for some anti-tumor agents in non-small cell lung cancer (NSCLC). A cohort of 785 Chinese patients with NSCLC who underwent resection from March 2016 to November 2017 in the First Affiliated Hospital of Guangzhou Medical Univer...

journal_title：Cancer science

authors： Liang W,Guo M,Pan Z,Cai X,Li C,Zhao Y,Liang H,Yang H,Wang Z,Chen W,Xu C,Yang X,Sun J,He P,Gu X,Yin W,He J

更新日期：2019-06-01 00:00:00

abstract：:Recent studies suggest that SIPA1 encoding a Rap GTPase-activating protein SPA-1 is a candidate metastasis efficiency-modifying gene in human breast cancer. In this study, we investigated the expression and function of SPA-1 in human prostate cancer (CaP). Immunohistochemical studies of tumor specimens from CaP patien...

journal_title：Cancer science

authors： Shimizu Y,Hamazaki Y,Hattori M,Doi K,Terada N,Kobayashi T,Toda Y,Yamasaki T,Inoue T,Kajita Y,Maeno A,Kamba T,Mikami Y,Kamoto T,Yamada T,Kanno T,Yoshikawa K,Ogawa O,Minato N,Nakamura E

更新日期：2011-04-01 00:00:00

abstract：:Autophagy plays a critical role in tumorigenesis, but how autophagy contributes to cancer cells' responses to chemotherapeutics remains controversial. To investigate the roles of autophagy in malignant gliomas, we used CRISPR/CAS9 to knock out the ATG5 gene, which is essential for autophagosome formation, in tumor cel...

journal_title：Cancer science

authors： Vu HT,Kobayashi M,Hegazy AM,Tadokoro Y,Ueno M,Kasahara A,Takase Y,Nomura N,Peng H,Ito C,Ino Y,Todo T,Nakada M,Hirao A

更新日期：2018-08-01 00:00:00

abstract：:Krüppel-like factor 5 (KLF5) plays an oncogenic role and has diverse functions in cancer cells. However, correlation between KLF5 and clinical outcome has not been determined in patients with colorectal cancer and colorectal liver metastasis. Herein, we analyzed 65 patients with colorectal cancer who developed colorec...

journal_title：Cancer science

authors： Takagi Y,Sakai N,Yoshitomi H,Furukawa K,Takayashiki T,Kuboki S,Takano S,Suzuki D,Kagawa S,Mishima T,Nakadai E,Miyauchi H,Matsubara H,Ohtsuka M

更新日期：2020-06-01 00:00:00

abstract：:We recently reported that compound 20d (comp.20d), a novel pyrrolo[3, 2-d]pyrimidine derivative, is a potent and selective inhibitor of tumor angiogenesis-related kinases, including vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR). In this study, we show that comp...

journal_title：Cancer science

authors： Awazu Y,Mizutani A,Nagase Y,Iwata H,Oguro Y,Miki H,Imamura S,Hori A

更新日期：2012-05-01 00:00:00

abstract：:Monitoring p53 transcriptional activity to identify genotoxic damages induced by drugs has been proposed and validated in vitro. However, this methodology is by design limited to the cell line tested. In this study, we have fully validated a luciferase-based p53-reporter system in vitro and in vivo. We generated a mou...

journal_title：Cancer science

authors： Briat A,Vassaux G

更新日期：2008-04-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers. OSCC generally has a poor prognosis due to its tendency towards local invasion and subsequent metastasis, which is mediated by multiple proteolytic enzymes and angiogenesis. The purpose of this study was to evaluate the anti-cancer ef...

journal_title：Cancer science

authors： Myoung H,Hong SP,Yun PY,Lee JH,Kim MJ

更新日期：2003-02-01 00:00:00