Abstract:
:Introduction: Spontaneous (non-traumatic) subarachnoid hemorrhage (ntSAH) is frequently suspected in the emergency department, but the incidence rate is low. Diagnosis registers can provide valuable data for research in uncommon conditions like ntSAH. Unfortunately, validity vary in the registers. We aimed to assess the validity of the ntSAH diagnosis in the Danish National Patient Register (DNPR) and secondly to describe patients misclassified as ntSAH and to calculate the incidence rate of ntSAH. Methods: From the DNPR we extracted information on patients at least 18 years of age on admission registered with a diagnosis of ntSAH and admitted to a hospital in the Capital Region of Denmark between January 1, 2008 and December 31, 2014. Two independent investigators reviewed the medical records to assess if the diagnosis could be confirmed. Those not confirmed were categorized according to a predeveloped case report form. Results: We identified 1101 patients with a diagnosis of ntSAH; medical records were accessible for 1069 (97.7%) and 842 (78.8%) met the inclusion criteria. The diagnosis was confirmed in 537 patients (63.8% (95% confidence interval: 60.5-67.0%)). Among patients where ntSAH was not confirmed, 122 (40.0%) had a traumatic subarachnoid hemorrhage (tSAH), ntSAH had been suspected in 57 (18.9%) patients but was not substantiated during admission, while parenchymal hemorrhages were identified in 45 (14.5%) patients. The incidence rate was 5.5 (95% CI: 4.9-6.1) per 100,000 persons per year. Conclusion: We found a positive predictive value (PPV) of 63.8% for the diagnosis of non-traumatic subarachnoid hemorrhage in the Danish National Patient Register. The low PPV suggests that care should be taken if unvalidated data are used for research and that results of previous studies should be interpreted with caution.
journal_name
Clin Epidemioljournal_title
Clinical epidemiologyauthors
Sonne A,Andersen JB,Rasmussen LSdoi
10.2147/CLEP.S197251subject
Has Abstractpub_date
2019-05-01 00:00:00pages
323-331issn
1179-1349pii
197251journal_volume
11pub_type
杂志文章abstract:Purpose:To report completeness of registered surgeries in the Danish hip arthroscopy registry (DHAR) and proportion of patients completing patient-reported outcome measures (PROMs) prior to surgery and at 1-year follow-up. Patients and Methods:Completeness was determined as the number of surgeries registered in DHAR i...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S264683
更新日期:2020-08-04 00:00:00
abstract:BACKGROUND:Data from the Nordic health care registers have been of great value in perinatal epidemiological research. It has been assumed that findings from the Nordic population (Denmark, Finland, Iceland, Norway, and Sweden) are applicable to other populations as well, including the population of the US. OBJECTIVE:T...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S106126
更新日期:2016-08-03 00:00:00
abstract:BACKGROUND:The aim of the present study was to validate the data in the Aarhus Sarcoma Registry (ASR), to determine if this registry is population-based for western Denmark, and to examine the incidence of sarcomas using validated, population-based registry data. METHODS:This study was based on patients with bone and ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S41835
更新日期:2013-03-06 00:00:00
abstract:Background:Hydroxychloroquine and chloroquine may reduce the risk of cancer as they inhibit autophagy, in particular, in people with connective tissue diseases. Methods:The hazard ratios of cancers, metastases, and death were assessed in adults with connective tissue diseases prescribed hydroxychloroquine/chloroquine ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S143563
更新日期:2017-11-03 00:00:00
abstract:Background:The combination of organized cervical cancer screening and childhood HPV vaccination programs has the potential to eliminate cervical cancer in the future. However, only women participating in both programs gain the full protection, and combined non-attenders remain at high risk of developing cervical cancer...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S203023
更新日期:2019-11-08 00:00:00
abstract:AIM OF THE DATABASE:The main purpose of the database of the Danish Renal Cancer Group (DaRenCaData) is to improve the quality of renal cancer treatment in Denmark and secondarily to conduct observational research. STUDY POPULATION:DaRenCaData includes all Danish patients with a first-time diagnosis of renal cancer in ...
journal_title:Clinical epidemiology
pub_type: 杂志文章,评审
doi:10.2147/CLEP.S106042
更新日期:2016-10-25 00:00:00
abstract:Background:In 2012, liver cancer ranked as the fifth and eighth most common cancer in men and women, respectively, in urban Shanghai. This study aims to present the trend and projection of age-specific incidence and mortality of liver cancer in Shanghai. Methods:We extracted data of liver cancer incident cases and dea...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S153951
更新日期:2018-03-09 00:00:00
abstract:AIM:In 2008, the Danish National Chronic Lymphocytic Leukemia Registry was founded within the Danish National Hematology Database. The primary aim of the registry is to assure quality of diagnosis and care of patients with chronic lymphocytic leukemia (CLL) in Denmark. Secondarily, to evaluate adherence to national gui...
journal_title:Clinical epidemiology
pub_type: 杂志文章,评审
doi:10.2147/CLEP.S99486
更新日期:2016-10-25 00:00:00
abstract:Purpose:To identify the characteristics and initial disease severity of patients with nonalcoholic fatty liver disease (NAFLD) and assess incidence and risk factors for disease progression in a retrospective study. Methods:Patients ≥18 years of age without alcoholism or other liver diseases (eg, hepatitis B/C) were se...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S144368
更新日期:2017-12-14 00:00:00
abstract:Purpose:To validate the use of International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes to identify patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in the Taiwan National Health Insurance (NHI) Outpatient Claims Dataset. Methods:We conducted ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S236823
更新日期:2020-02-20 00:00:00
abstract:Objective:To investigate the impact of moderate wine consumption on the risk of prostate cancer (PCa). We focused on the differential effect of moderate consumption of red versus white wine. Design:This study was a meta-analysis that includes data from case-control and cohort studies. Materials and methods:A systemat...
journal_title:Clinical epidemiology
pub_type: 杂志文章,评审
doi:10.2147/CLEP.S163668
更新日期:2018-04-17 00:00:00
abstract:BACKGROUND:With the emergence of new lipid-lowering therapies, more patients are expected to achieve substantial lowering of low-density lipoprotein cholesterol (LDL-C). However, there are limited data examining the clinical experience of patients with low (<1.3 mmol/L) or very low (<0.65 mmol/L) levels of LDL-C. To pr...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S77676
更新日期:2015-02-26 00:00:00
abstract:Objective:Maternal thyroid disease (TD) during pregnancy is associated with adverse birth outcomes, but little is known on its long-term outcomes. We aimed to examine if children born to mothers with TD have increased disease risk during childhood and adolescence. Patients and methods:A register-based cohort study was...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S167128
更新日期:2018-09-28 00:00:00
abstract:OBJECTIVES:Translational epidemiology studies often use archived tumor specimens to evaluate genetic hypotheses involving cancer outcomes. When the exposure of interest is a germline polymorphism, a key concern is whether the genotype assayed from tumor-derived DNA is representative of the germline. We evaluated the co...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S13811
更新日期:2010-10-22 00:00:00
abstract::The management of brain-dead organ donors is complex. The use of inotropic agents and replacement of depleted hormones (hormonal replacement therapy) is crucial for successful multiple organ procurement, yet the optimal hormonal replacement has not been identified, and the statistical adjustment to determine the best ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S71403
更新日期:2014-12-22 00:00:00
abstract:Background:Primary care databases represent a rich source of data for health care research; however, the quality of recording of secondary care events in these databases is uncertain. This study sought to investigate the completeness of recording of hospital admissions for bleeds in primary care records and explore the...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S170304
更新日期:2018-09-04 00:00:00
abstract:Objective:To evaluate the long-term risk of stroke and poststroke adverse outcomes in patients with heart failure (HF). Methods:We used research data from Taiwan's National Health Insurance Program from 2000 to 2005 and identified 20,072 adults aged ≥30 years who were newly diagnosed with HF. Frequency matching based ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S261179
更新日期:2020-11-05 00:00:00
abstract:BACKGROUND:Data on the safety of selective serotonin-reuptake inhibitors (SSRIs) in pregnancy are inconsistent. We examined associations between SSRI use during early pregnancy and risk of congenital malformations in infants. METHODS:Set in Northern Denmark, our population-based prevalence study included 216,042 women...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/clep.s9256
更新日期:2010-08-09 00:00:00
abstract:INTRODUCTION:Few modern population-based estimates of the prognosis of ruptured abdominal aortic aneurysm (rAAA) exist. METHODS AND MATERIALS:From 1994-2008, a total of 6954 rAAA cases were identified in Danish nationwide population-based registries. RESULTS:Of 3148 (45%) surgery cases, 1454 (46%) died within 30 days...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S31098
更新日期:2012-01-01 00:00:00
abstract:Objective:Reports on the epidemiology of vestibular schwannoma (VS) indicate an increase in diagnosed cases, often based on selected materials over a limited period of time. This report presents prospective 40-year epidemiological data from an unselected national cohort of all patients diagnosed with a VS in Denmark si...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S218670
更新日期:2019-11-08 00:00:00
abstract:Background:Prenatal exposures may contribute to male infertility in adult life, but large-scale epidemiological evidence is still lacking. The Fetal Programming of Semen quality (FEPOS) cohort was founded to provide means to examine if fetal exposures can interfere with fetal reproductive development and ultimately lea...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S242631
更新日期:2020-07-17 00:00:00
abstract:BACKGROUND:A number of population-based studies have demonstrated lower cancer survival in elderly patients than among middle-aged or younger patients. Also, data quality in cancer registries has been shown to be associated with age. The objective of this study was to examine the recent age-specific cancer survival tre...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S87699
更新日期:2015-07-29 00:00:00
abstract:Background:The Swedish Quality Register for Inflammatory Bowel Disease (SWIBREG) contains clinical data for the study of inflammatory bowel disease (IBD). The Epidemiology Strengthened by histoPathology Reports in Sweden (ESPRESSO) cohort was recently established for the study of gastrointestinal histopathology. We aim...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S265404
更新日期:2020-10-09 00:00:00
abstract:AIM OF DATABASE:The aim of the Danish Anaesthesia Database (DAD) is the nationwide collection of data on all patients undergoing anesthesia. Collected data are used for quality assurance, quality development, and serve as a basis for research projects. STUDY POPULATION:The DAD was founded in 2004 as a part of Danish C...
journal_title:Clinical epidemiology
pub_type: 杂志文章,评审
doi:10.2147/CLEP.S99517
更新日期:2016-10-25 00:00:00
abstract:Purpose:Anemia is prevalent in patients with chronic kidney disease (CKD), but the longitudinal risk of anemia in patients with newly identified CKD is unknown. We therefore examined the risks of experiencing anemia in persons with newly identified CKD. Patients and Methods:This cohort study included adult patients wi...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S259648
更新日期:2020-09-11 00:00:00
abstract:Purpose:This paper aims to compare the clinical effectiveness of oral anti-osteoporosis drugs based on the observed risk of fracture while on treatment in primary care actual practice. Materials and methods:We investigated two primary care records databases covering UK National Health Service (Clinical Practice Resear...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S164112
更新日期:2018-10-09 00:00:00
abstract:Purpose:Comorbidity indices are often used to measure comorbidities in register-based research. We aimed to adapt the Charlson comorbidity index (CCI) to a Swedish setting. Methods:Four versions of the CCI were compared and evaluated by disease-specific experts. Results:We created a cohesive coding system for CCI to ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S282475
更新日期:2021-01-12 00:00:00
abstract:BACKGROUND:Large-scale clinical registries are increasingly recognized as important resources for quality assurance and research to inform clinical decision-making and health policy. We established a clinical registry (SpineData) in a conservative care setting where more than 10,000 new cases of spinal pain are assesse...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S83830
更新日期:2015-08-13 00:00:00
abstract:PURPOSE:Large-scale observational studies based on existing medical databases may have an important role in studies of long-term effects of different treatments in prostate cancer patients if the coding of the treatment is valid. We therefore estimated the positive predictive value (PPV) and negative predictive value (...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S32313
更新日期:2012-01-01 00:00:00
abstract:Purpose:Substantial heterogeneity exists in reported kidney function decline in pre-dialysis chronic kidney disease (CKD). By design, kidney function decline can be studied in CKD 3-5 cohorts or dialysis-based studies. In the latter, patients are selected based on the fact that they initiated dialysis, possibly leading...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S153367
更新日期:2018-05-25 00:00:00