Combined fibrinogen and neutrophil-lymphocyte ratio as a predictive factor in resectable colorectal adenocarcinoma.


Purpose:The aim of this study was to investigate the clinical significance of the combined fibrinogen and neutrophil-lymphocyte ratio (F-NLR) in patients with resectable colorectal cancer (CRC). Patients and methods:We retrospectively recruited 693 patients with stage I-III CRC following curative surgery. Cutoff values of the preoperative fibrinogen and neutrophil-lymphocyte ratio (NLR) were determined with the receiver operating characteristic analysis. Patients were divided into three groups based on the F-NLR value and were further divided into the chemotherapy and nonchemotherapy groups. The overall survival (OS) and disease-free survival (DFS) were evaluated with the Kaplan-Meier survival method, the log-rank test, univariate and multivariate Cox proportional hazards models, and subgroup analyses. Results:The Kaplan-Meier survival curves revealed that the 5-year OS rates in the F-NLR 0, 1, and 2 groups were 78.4%, 52%, 42.6%, respectively (P<0.001), and the 5-year DFS rates were 54.9%, 43.9%, 26.7%, respectively (P<0.001). Multivariate analyses revealed that the F-NLR score was an independent prognostic factor for both the OS (P=0.035) and the DFS (P=0.001). In addition, subgroup analyses based on the histological type showed that an elevated F-NLR score was significantly associated with worse OS (P=0.001) and DFS (P<0.001) in patients with colorectal adenocarcinoma. Furthermore, DFS in the F-NLR 0-1 group was significantly shortened after the administration of chemotherapy (P=0.005); however, patients with a relatively higher F-NLR score showed slight OS benefit from adjuvant chemotherapy (P=0.144). Conclusion:The F-NLR score, as a novel inflammation-based grading index, was a potential predictor for the prognosis and responses to chemotherapy in patients with resectable CRC.


Cancer Manag Res


Li X,An B,Zhao Q,Qi J,Wang W,Zhang D,Li Z,Qin C




["colorectal cancer","fibrinogen","inflammation","neutrophil-lymphocyte ratio","prognosis"]


Has Abstract


2018-11-26 00:00:00










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    更新日期:2021-01-06 00:00:00

  • LACTB Regulates PIK3R3 to Promote Autophagy and Inhibit EMT and Proliferation Through the PI3K/AKT/mTOR Signaling Pathway in Colorectal Cancer.

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  • Evaluation of selected ultrasound features of thyroid nodules with atypia of undetermined significance/follicular lesion of undetermined significance for the Bethesda reporting system for thyroid cytology.

    abstract:Background and objective:The risk of malignancy from "atypia of undetermined significance/follicular lesion of undetermined significance" (AUS/FLUS) is estimated to lie between 5% and 15%; however, some authors suggest that the risk of malignancy in AUS/FLUS depends upon specific clinical situations. This was a retrosp...

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    authors: Kaliszewski K,Diakowska D,Wojtczak B,Forkasiewicz Z

    更新日期:2018-07-23 00:00:00

  • Long-term survival effect of the interval between mastectomy and radiotherapy in locally advanced breast cancer.

    abstract:Introduction:The timing of postmastectomy radiotherapy (PMRT) may influence locoregional recurrence and survival outcomes. In this study, we assessed the long-term survival effect of the interval between surgery and PMRT in locally advanced breast cancer treated with mastectomy and adjuvant chemotherapy. Methods:In th...

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    authors: Zhang WW,Wu SG,Sun JY,Li FY,He ZY

    更新日期:2018-07-16 00:00:00

  • Human leukocyte antigen gene polymorphisms are associated with systemic inflammation in hepatitis B virus-related hepatocellular carcinoma.

    abstract:Background:Systemic inflammation (SI) is associated with tumor progression and overall survival (OS) in patients with hepatocellular carcinoma (HCC). The presence of some single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA) region can influence the prognosis of patients with hepatitis B virus (HB...

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    更新日期:2018-07-31 00:00:00

  • High expression of dedicator of cytokinesis 1 adversely influences the prognosis of acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation.

    abstract::Background: Overexpression of dedicator of cytokinesis 1 (DOCK1) has been confirmed as an unfavorable prognostic marker in acute myeloid leukemia (AML). Purpose: This study is to explore the clinical implications of DOCK1 on AML patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). Patient...

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  • Prediction of Overall Survival of Patients with Completely Resected Non-Small Cell Lung Cancer: Analyses of Preoperative Spirometry, Preoperative Blood Tests, and Other Clinicopathological Data.

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    authors: Shi M,Zhan C,Shi J,Wang Q

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    authors: Huang H,Yang X,Sun J,Zhu C,Wang X,Zeng Y,Xu J,Mao C,Shen X

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    authors: Peak SJ,Levin VA

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    authors: Simson DK,Mitra S,Ahlawat P,Saxena U,Sharma MK,Rawat S,Singh H,Bansal B,Sripathi LK,Tanwar A

    更新日期:2018-03-19 00:00:00

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    abstract:Objective:To investigate the effects of different values of the body mass index (BMI) on postoperative hemorrhage (PH) in thyroid cancer (TC) and its clinical management. Methods:This retrospective cohort study selected 43 patients with hemorrhage after TC surgery in 7413 cases. Patients were divided based on the BMI ...

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    authors: Li P,Luo R,Guo L,Li W,Qi J

    更新日期:2020-01-23 00:00:00

  • EGFR-TKI-sensitive mutations in lung carcinomas: are they related to clinical features and CT findings?

    abstract:Background:Epidermal growth factor receptor (EGFR) mutation testing is restricted to several limitations. In this study, we examined the relationship between EGFR mutation status and clinicoradiological characteristics in a Chinese cohort of patients. Materials and methods:The data of patients who were diagnosed with ...

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    authors: Qin X,Gu X,Lu Y,Zhou W

    更新日期:2018-10-01 00:00:00

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    authors: Feng J,Zhan Y,Zhang Y,Zheng H,Wang W,Fan S

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    authors: Zhang L,Yu J,Huang W,Zhang H,Xu J,Cai H

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    authors: Welker MW,Trojan J

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    authors: Fu Y,Yang X,Liang H,Wu X

    更新日期:2019-05-31 00:00:00

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    abstract:Background:Glioma is a prevalent disease of the central nervous system with a high incidence and mortality rate. Many long noncoding RNAs (lncRNAs) have been determined to be critical regulators of glioma oncogenesis. However, the function and mechanism of LINC00963 in glioma have not been fully elucidated. Methods:Th...

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    authors: Ye F,Xu R,Ge Y,Zheng Y,Liu X,Deng P,Xu X

    更新日期:2020-03-27 00:00:00

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    authors: Guo XW,Liu YC,Gao F,Ji SJ,Zhou JY,Ji L,Zhou SB

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  • Prognostic Significance of Preoperative Gamma-Glutamyltransferase to Alkaline Phosphatase Ratio in Hepatocellular Carcinoma Patients with Curative Liver Resection: A Retrospective Cohort Study.

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    authors: Ouyang G,Pan G,Wu Y,Liu Q,Lu W,Chen X

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  • Alcohol consumption, tobacco smoking, betel quid chewing and oral health associations with hypopharyngeal cancer among men in Central South China: a case-control study.

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    journal_title:Cancer management and research

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    authors: Zeng J,Tang Y,Wu P,Fang X,Wang W,Fan Y,Li X,Zhao S

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  • Decreased expression of TRIM21 indicates unfavorable outcome and promotes cell growth in breast cancer.

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    journal_title:Cancer management and research

    pub_type: 杂志文章


    authors: Zhou W,Zhang Y,Zhong C,Hu J,Hu H,Zhou D,Cao M

    更新日期:2018-09-20 00:00:00

  • Survival and Clinical Outcomes with Telotristat Ethyl in Patients with Carcinoid Syndrome.

    abstract:Purpose:The TELEACE study showed reductions in tumor size in patients with neuroendocrine tumors, receiving telotristat ethyl in US clinical practice. Here, we report progression-free survival, time to tumor progression, changes in carcinoid syndrome symptoms, and indictors of overall health. Patients and Methods:This...

    journal_title:Cancer management and research

    pub_type: 杂志文章


    authors: Metz DC,Liu E,Joish VN,Huynh L,Totev TI,Duh MS,Seth K,Giacalone S,Lapuerta P,Morse MA

    更新日期:2020-10-07 00:00:00

  • Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules

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    journal_title:Cancer management and research

    pub_type: 杂志文章


    authors: Lyu YJ,Shen F,Yan Y,Situ MZ,Wu WZ,Jiang GQ,Chen YY

    更新日期:2019-02-07 00:00:00

  • Development and Validation of a Nomogram Predicting the Prognosis of Renal Cell Carcinoma After Nephrectomy.

    abstract:Objective:To develop and validate a nomogram for predicting the overall survival (OS) of renal cell carcinoma (RCC) patients after nephrectomy. Materials and Methods:In total, 488 patients with RCC who underwent nephrectomy at the Urology Department of the First Hospital of Shanxi Medical University between January 20...

    journal_title:Cancer management and research

    pub_type: 杂志文章


    authors: Xia M,Yang H,Wang Y,Yin K,Bian X,Chen J,Shuang W

    更新日期:2020-06-11 00:00:00

  • Predicting Recurrence in Endometrial Cancer Based on a Combination of Classical Parameters and Immunohistochemical Markers.

    abstract:Objective:The aim of this study was to establish a nomogram to predict the recurrence of endometrial cancer (EC) by immunohistochemical markers and clinicopathological parameters and to evaluate the discriminative power of this model. Methods:The data of 473 patients with stages I-III endometrial cancer who had receiv...

    journal_title:Cancer management and research

    pub_type: 杂志文章


    authors: Jiang P,Huang J,Deng Y,Hu J,Huang Z,Jia M,Long J,Hu Z

    更新日期:2020-08-18 00:00:00

  • Impact of physical activity and sleep quality on quality of life of rural residents with and without a history of cancer: findings of the Day and Night Study.

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    journal_title:Cancer management and research

    pub_type: 杂志文章


    authors: Rafie C,Ning Y,Wang A,Gao X,Houlihan R

    更新日期:2018-11-09 00:00:00

  • Management of hemorrhage in gastrointestinal stromal tumors: a review.

    abstract::Gastrointestinal stromal tumors (GISTs) are relatively common mesenchymal tumors. They originate from the wall of hollow viscera and may be found in any part of the digestive tract. The prognosis of patients with stromal tumors depends on various risk factors, including size, location, presence of mitotic figures, and...

    journal_title:Cancer management and research

    pub_type: 杂志文章,评审


    authors: Liu Q,Kong F,Zhou J,Dong M,Dong Q

    更新日期:2018-04-12 00:00:00

  • Cancer therapy and cardiovascular risk: focus on bevacizumab.

    abstract::Recognition and management of treatment-related cardiovascular toxicity, defined as either an acute cardiac event or a chronic condition, has been tightly integrated into routine cancer care and has become an important component in treatment selection. Several chemotherapeutic agents, such as anthracyclines, are tradi...

    journal_title:Cancer management and research

    pub_type: 杂志文章,评审


    authors: Economopoulou P,Kotsakis A,Kapiris I,Kentepozidis N

    更新日期:2015-06-03 00:00:00

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    abstract:Background:Breast cancer (BC) is the most commonly diagnosed cancer in women. Tumor recurrence and metastasis are the key causes of death in BC patients. Long non-coding RNA (lncRNA) is closely associated with BC progression. lncRNA nuclear-enriched abundant transcript (NEAT)1 has been reported to regulate the prolifer...

    journal_title:Cancer management and research

    pub_type: 杂志文章


    authors: Li S,Hao J,Hong Y,Mai J,Huang W

    更新日期:2020-07-21 00:00:00