The psychopharmacotherapy of anorexia nervosa: clinical, neuroendocrine and metabolic aspects.

Abstract:

:Anorexia nervosa (AN) is a complex mental disorder presenting psychiatric and physical symptoms. Literature recognizes the role of several factors in the pathogenesis of this disorder, according to the biopsychosocial model. Many mechanisms are still partly unclear. Endocrine and metabolic alterations usually occur in AN, probably having a role in its pathogenesis and in the disorder perseverance. In consideration of the multifactorial pathogenesis, a multidisciplinary approach is needed in the treatment of anorexic patients. Up-to-date psychotherapy, psychopharmacological, endocrine and nutritional treatments are considered effective in improving AN. Literature does not however provide evidence of a single validated psychopharmacotherapy for anorexic patients. It is known that psychopharmacotherapy can influence hormonal and metabolic states in some conditions, but for the moment few data are present about these effects in AN. This article aims to review the data about the psychopharmacotherapy role in AN, focusing on the endocrine and metabolic effects of anti-depressants (AD) and novel antipsychotic drugs which seem to be the most effective in AN. Scant data are however available and further research should provide more evidence about these effects and also assess whether the severity of the neuroendocrine, hormonal and metabolic impairments can predict the lack of response to the psychopharmacological treatment with AD and neuroleptics.

journal_name

J Endocrinol Invest

authors

Abbate Daga G,Gianotti L,Mondelli V,Quartesan R,Fassino S

doi

10.1007/BF03347545

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

975-81

issue

10

eissn

0391-4097

issn

1720-8386

pii

5176

journal_volume

27

pub_type

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