Use of inhaled corticosteroids during pregnancy and risk of pregnancy induced hypertension: nested case-control study.

Abstract:

OBJECTIVE:To determine whether the use of inhaled corticosteroids during pregnancy increases the risk of pregnancy induced hypertension and pre-eclampsia among asthmatic women. DESIGN:Nested case-control study. SETTING:Three administrative health databases from Quebec: RAMQ, MED-ECHO, and Fichier des evenements demographiques. PARTICIPANTS:3505 women with asthma, totalling 4593 pregnancies, between 1990 and 2000. MAIN OUTCOME MEASURES:Pregnancy induced hypertension and pre-eclampsia. RESULTS:302 cases of pregnancy induced hypertension and 165 cases of pre-eclampsia were identified. Use of inhaled corticosteroids from conception until date of outcome was not associated with an increased risk of pregnancy induced hypertension (adjusted odds ratio 1.02, 95% confidence interval 0.77 to 1.34) or pre-eclampsia (1.06, 0.74 to 1.53). No significant dose-response relation was observed between inhaled corticosteroids and pregnancy induced hypertension or pre-eclampsia. Oral corticosteroids were significantly associated with the risk of pregnancy induced hypertension (adjusted odds ratio 1.57, 1.02 to 2.41), and a trend was seen for pre-eclampsia (1.72, 0.98 to 3.02). CONCLUSION:No significant increase of the risk of pregnancy induced hypertension or pre-eclampsia was detected among users of inhaled corticosteroids during pregnancy, while markers of uncontrolled and severe asthma were found to significantly increase the risks of pregnancy induced hypertension and pre-eclampsia.

journal_name

BMJ

authors

Martel MJ,Rey E,Beauchesne MF,Perreault S,Lefebvre G,Forget A,Blais L

doi

10.1136/bmj.38313.624352.8F

keywords:

subject

Has Abstract

pub_date

2005-01-29 00:00:00

pages

230

issue

7485

eissn

0959-8138

issn

1756-1833

pii

bmj.38313.624352.8F

journal_volume

330

pub_type

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