Abstract：
:We report two patients with incidentally discovered enlarged parathyroid glands while performing neck ultrasonography (US) for thyroid nodules. The parathyroid masses were seen as hypoechoic, homogeneous, oval nodules, separated from the thyroid gland. Both patients were completely asymptomatic, although subclinical evidence of hyperparathyroidism (serum PTH and calcium levels in the upper limit of the normal range, increased ionized serum calcium, osteocalcin, urinary calcium and hydroxyproline) was subsequently found in one patient. An enhanced uptake on sesta-MIBI scinti scan was concordant with the US finding in the two cases. PTH levels in the wash-out from the US-guided fine needle aspiration biopsy, confirmed the parathyroid origin of the lesions. Cytology and immunocytochemistry were, in our cases, unreliable diagnostic procedures. The extensive use of US imaging in thyroid pathology may increase the finding of US incidentally discovered parathyroid adenomas. The early detection of silent parathyroid pathologic findings may extend the natural history of these masses to a preclinical stage. Further investigations are necessary to evaluate the evolution of parathyroid incidentalomas and therefore their clinical significance.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Pesenti M,Frasoldati A,Azzarito C,Valcavi Rdoi
10.1007/BF03343646keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
796-9issue
10eissn
0391-4097issn
1720-8386journal_volume
22pub_type
杂志文章abstract：OBJECTIVE:Thyroid hormone resistance (RTH β) is a rare genetic disorder characterized by an altered response of target tissue to the action of thyroid hormone. Few studies on RTH β have been carried out in southern European populations. We aimed to describe the clinical and genetic characteristics at the time of diagno...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-019-1007-4
更新日期：2019-08-01 00:00:00
abstract：:Disulfide bonds are formed between the sulfhydryl groups in two cysteine residues of a protein. The formation of these bonds is necessary for the proper folding of a protein into its active three-dimensional form. In this study, the genes associated with disulfide bond formation of proteins from the rat thyroid cell l...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345141
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Adiponectin, a fat derived cytokine, is a potential independent contributor to bone mineral density (BMD); however, its action on bone metabolism in humans is still unclear. AIM:The aim of this study was to investigate the relationship of adiponectin with bone mass indices and bone metabolic markers in midd...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/7744
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:Growth hormone deficiency (GHD) is the most common endocrine late effect observed in childhood cancer survivors (CCS) previously submitted to cranial irradiation. Radiation therapy can also increase the risk of second neoplasms (SNs). Since in previous studies GH replacement therapy was associated with increase...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-014-0179-1
更新日期：2015-02-01 00:00:00
abstract：:A 34-yr-old nulliparous black woman presented with hair loss, facial hirsutism, irregular menses and infertility associated with greatly increased serum total testosterone levels. The adrenal glands and the ovaries were normal on radiological and ultrasonographic investigation. Catheterization of the veins draining fr...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348033
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVE:We aimed to investigate the differences in emotional and behavioral problems and to explore the association between the level of psychiatric problems and the metabolic control in Type 1 diabetes. METHODS:The children with Type 1 diabetes (no.=42) and the "healthy" control group (no.=42), their parents and en...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345721
更新日期：2009-04-01 00:00:00
abstract：:The case of a 34-yr-old Caucasian male with Graves' disease presenting with a flaccid quadriplegia and severe hypokalemia is reported. The weakness was prevalent at the lower extremities and began during nocturnal sleep, after a strenuous physical exertion performed during the day. Correction of hypokalemia promptly r...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347807
更新日期：1995-03-01 00:00:00
abstract：:Stroke is one of the main causes of death and disability in the adult population. Changes in pituitary hormone secretion may be observed during the acute phase of stroke, representing part of the adaptive response to injury. However, reduced pituitary hormone secretion, caused by pituitary and/or hypothalamus damage, ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2008-09-01 00:00:00
abstract：:Iodine balance during pregnancy and lactation was investigated by measuring iodine concentration in the urine of 11 pregnant women, born and living in a moderately iodine deficient endemic goiter area in Northeastern Sicily, collected during the last week of pregnancy, and between the 5th and 7th day after delivery, a...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348681
更新日期：1992-02-01 00:00:00
abstract：:Serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) responses to exposure to sea-level altitude (LA) were examined in 13 eugonadal males, age 21-22 yr, 3 and 5 days after residing at LA and on the second day of return to basal altitude 90 days later. After 3 days at the...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350195
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVE:We previously demonstrated that patients suffering from moderate hypothyroidism were at increased risk of thrombosis contrasting with the bleeding tendency of those presenting severe hypothyroidism. The latter state is associated with hemostatic anomalies including von Willebrand type 1 disease and increased ...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.1007/BF03347217
更新日期：2005-05-01 00:00:00
abstract：COPEPTIN:Copeptin is secreted in equimolar amount to Arginine Vasopressin (AVP) but can easily be measured with a sandwich immunoassay. Both peptides, copeptin and AVP, show a high correlation. Accordingly, copeptin mirrors the amount of AVP in the circulation and its measurement provides an attractive marker in the di...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-019-01087-6
更新日期：2020-01-01 00:00:00
abstract：:The multiple effects of vitamin D on skeletal and extra-skeletal tissues increased the attention of scientists and public to the possible relationship between hypovitaminosis D and a variety of acute and chronic diseases. However, several points are still largely debated. In particular, the definition of optimal vitam...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-014-0071-z
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:In the last decades, a higher incidence of congenital hypothyroidism (CH) has been recorded in Italy (1:1940) and worldwide, mainly due to the shift to lower screening TSH cutoffs. Although CH can also be caused by dysgenetic defects, most CH cases have recently been found to be more frequently associated wi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-015-0288-5
更新日期：2015-08-01 00:00:00
abstract：:Established methods for definitive ablation of autonomous thyroid nodules are surgery and radioiodine. Since it has been demonstrated that percutaneous ethanol injection can inactivate parathyroid adenomas and small hepatocellular carcinomas, we started a trial of this treatment in patients with autonomous thyroid nod...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348753
更新日期：1992-05-01 00:00:00
abstract：:To analyze the inhibitory effect of hormone replacement therapy (HRT) on bone resorption, we measured urinary excretion of C-telopeptide (CTX) and N-telopeptide (NTX) of type I collagen as new markers of bone resorption and assessed their correlation with bone mineral density, in comparison with urinary pyridinoline (...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347294
更新日期：1998-03-01 00:00:00
abstract：:During a systematic study of women with idiopathic galactorrhea, we observed several patients with normal random serum prolactin (PRL) levels and normal menses, but abnormal sellar tomograms characteristic of a pituitary adenoma. To test the hypothesis that these women might have intermittent PRL hypersecretion, we st...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348450
更新日期：1984-10-01 00:00:00
abstract：BACKGROUND:Bone marrow mesenchymal stem cells (MSC) mediate their protection by paracrine mechanism under ischemic conditions and anoxic pre-conditioning (AP) of MSC strongly enhances their survival and regenerative capacity. However, there is no report about the therapeutic potency of MSC transplantation on diabetic c...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345575
更新日期：2008-02-01 00:00:00
abstract：:Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to re...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-018-0849-5
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Remission of acromegaly has been reported after somatostatin analogs withdrawal, but not after withdrawal of combination therapy with cabergoline, and only in case reports of patients controlled by cabergoline alone. METHODS:To establish the remission rates (normal IGF-1 for age/sex: IGF-1 ≤ 1.00 xULN) after w...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,多中心研究
doi：10.1007/s40618-016-0595-5
更新日期：2017-05-01 00:00:00
abstract：:Plasma insulin immunoreactivity (IRI) results from high molecular weight substances with insulin immunoreactivity (HWIRI), proinsulin (PI) and insulin (I). Their respective concentrations and percentages of IRI were determined preoperatively in the hepatic and peripheral circulations and after surgery in the latter tw...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350520
更新日期：1982-09-01 00:00:00
abstract：:Nine chronic male alcoholics presenting with hypogonadism but without overt liver failure were examined under baseline conditions and after acute injection of gonadotropin releasing hormone (GnRH, 100 micrograms iv) and thyrotropin releasing hormone (TRH, 200 micrograms iv), performed at 60 min of a 3-h infusion of sa...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03348339
更新日期：1983-12-01 00:00:00
abstract：:To assess the role of the renin-angiotensin system in the control of aldosterone reease in response to heat exposure, 6 sodium restricted subjects were studied on three random experimental days: a control day and two heat exposure days (46C, 35 mbar, 90 min) with and without propranolol. Plasma aldosterone, renin acti...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03349377
更新日期：1980-10-01 00:00:00
abstract：:The aim of acromegaly treatment is to control the disease by suppressing GH hyperactivity and reducing the size or impeding the growth of the pituitary GH secreting mass. Over recent years, many studies have emphasized the role of SS analogs in the treatment of acromegaly. In fact, SS analogs have been demonstrated to...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03349183
更新日期：2006-01-01 00:00:00
abstract：:Hexarelin (Hex) is a synthetic hexapeptide with potent GH-releasing activity in both animals and men. Aim of this study was to evaluate the GH response to a maximal dose of Hex and GH-releasing hormone (GHRH) in a group of patients with Prader-Willi syndrome (PWS). Seven patients (4 boys and 3 girls, age 2.4-14.2 yr) ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347335
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:In the mountainous areas of Azerbaijan the schoolchildren suffer from severe Iodine Deficiency (ID) with median Urinary iodine excretion (UIE) 36 mcg/l and prevalence of goiter 99% (estimated by US). In a population of 293,000 schoolchildren aged 8-14 y.o. we administered capsules containing 190 mg of iodized...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Short stature homeobox-containing (SHOX) gene mutations causing haploinsufficiency have been reported in idiopathic short stature, but the real prevalence of this defect in the population with growth failure is debated. Based on current data, the prevalence of SHOXdefect (SHOX-D) has been calculated to have occurred i...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:Following presentation and diagnosis, microprolactinomas usually follow a benign course and rarely progress to macroprolactinomas. However, clinically significant enlargement of prolactinomas during pregnancy, presumably related to estrogen stimulation, has been reported. This report describes a patient with amenorrhe...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349744
更新日期：1995-06-01 00:00:00
abstract：:This study was performed to determine whether phenotypically healthy sisters of women with polycystic ovary syndrome (PCOS) have evidence of insulin resistance. We studied 54 women: 17 with PCOS, 17 sisters of these probands and 20 control women with similar age, body mass index (BMI) and waist-to-hip ratio (WHR). The...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347535
更新日期：2004-11-01 00:00:00
abstract：:Pheochromocytoma resection is often complicated by intra-operative hypertension and post-resection hypotension. Factors associated with these hemodynamic alterations are not well defined. The aim of this study was to analyse the clinical-laboratory features associated with hemodynamic parameters during pheochromocytom...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346458
更新日期：2009-03-01 00:00:00
