First day neonatal mortality since 1935: re-examination of the Cross hypothesis.

abstract：OBJECTIVE:To evaluate the effect of support with human chorionic gonadotrophin in the luteal phase in women taking part in an in vitro fertilisation programme after buserelin and human menopausal gonadotrophin were used to hyperstimulate their ovaries. DESIGN:Controlled group comparison. SETTING:Outpatient department...

journal_title：BMJ (Clinical research ed.)

authors： Smith EM,Anthony FW,Gadd SC,Masson GM

更新日期：1989-06-03 00:00:00

abstract：OBJECTIVES:To determine the prevalence of antibodies to hepatitis B core antigen, hepatitis C virus, and HIV in entrants to Irish prisons and to examine risk factors for infection. DESIGN:Cross sectional, anonymous survey, with self completed risk factor questionnaire and oral fluid specimen for antibody testing. SET...

journal_title：BMJ (Clinical research ed.)

authors： Long J,Allwright S,Barry J,Reynolds SR,Thornton L,Bradley F,Parry JV

更新日期：2001-11-24 00:00:00

abstract：OBJECTIVES:To assess whether supplementation with antioxidants, folinic acid, or both improves the psychomotor and language development of children with Down's syndrome. DESIGN:Randomised controlled trial with two by two factorial design. SETTING:Children living in the Midlands, Greater London, and the south west of ...

journal_title：BMJ (Clinical research ed.)

authors： Ellis JM,Tan HK,Gilbert RE,Muller DP,Henley W,Moy R,Pumphrey R,Ani C,Davies S,Edwards V,Green H,Salt A,Logan S

更新日期：2008-03-15 00:00:00

abstract：OBJECTIVE:To compare the clinical effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts. DESIGN:A multicentre, open, two arm randomised controlled trial. SETTING:University podiatry school clinics, NHS podiatry clinics, and primary care in England, Scotland, and Ireland. PARTICIPANTS:...

journal_title：BMJ (Clinical research ed.)

authors： Cockayne S,Hewitt C,Hicks K,Jayakody S,Kang'ombe AR,Stamuli E,Turner G,Thomas K,Curran M,Denby G,Hashmi F,McIntosh C,McLarnon N,Torgerson D,Watt I,EVerT Team.

更新日期：2011-06-07 00:00:00

abstract：OBJECTIVE:To estimate the risk of acute hepatotoxicity associated with nimesulide compared with other non-steroidal anti-inflammatory drugs. DESIGN:Retrospective cohort and nested case-control study. SETTING:Umbria region, Italy. PARTICIPANTS:400 000 current, recent, and past users (almost 2 million prescriptions) o...

journal_title：BMJ (Clinical research ed.)

authors： Traversa G,Bianchi C,Da Cas R,Abraha I,Menniti-Ippolito F,Venegoni M

更新日期：2003-07-05 00:00:00

abstract：OBJECTIVE:To determine whether the increased iron demands of pregnancy could be met by increased absorption from dietary sources. DESIGN AND SETTING:Longitudinal prospective study in the research unit of a maternity hospital. SUBJECTS:12 normal pregnant women. INTERVENTIONS:At 12, 24, and 36 weeks' gestation (within...

journal_title：BMJ (Clinical research ed.)

authors： Barrett JF,Whittaker PG,Williams JG,Lind T

更新日期：1994-07-09 00:00:00

abstract：OBJECTIVE:To investigate the differences between skeletal and chronological age and to assess the role of maturity status, anthropometric data, and football related variables in explaining injury statistics in elite schoolboy footballers. DESIGN:Prospective study of injuries in schoolboy footballers according to skele...

journal_title：BMJ (Clinical research ed.)

authors： Johnson A,Doherty PJ,Freemont A

更新日期：2009-02-26 00:00:00

abstract：OBJECTIVE:To determine which treatments for preventing coronary heart disease should be offered to which patients by assessing their incremental cost effectiveness. DESIGN:Modelling study. DATA SOURCES:Cost estimates (for NHS) and estimates of effectiveness obtained for aspirin, antihypertensive drugs, statins and cl...

journal_title：BMJ (Clinical research ed.)

authors： Marshall T

更新日期：2003-11-29 00:00:00

abstract：OBJECTIVES:To determine whether fibrinogen and lipid concentrations are risk factors for ischaemic stroke. DESIGN:Case-control study with a population based comparison within the overall study. SETTING:Oxfordshire community stroke project and a neurology clinic. SUBJECTS:105 patients who had a transient ischaemic at...

journal_title：BMJ (Clinical research ed.)

authors： Qizilbash N,Jones L,Warlow C,Mann J

更新日期：1991-09-14 00:00:00

abstract：OBJECTIVE:To assess treatment related changes in quality of life up to 15 years after diagnosis of localised prostate cancer. DESIGN:Population based, prospective cohort study with follow-up over 15 years. SETTING:New South Wales, Australia. PARTICIPANTS:1642 men with localised prostate cancer, aged less than 70, an...

journal_title：BMJ (Clinical research ed.)

authors： Mazariego CG,Egger S,King MT,Juraskova I,Woo H,Berry M,Armstrong BK,Smith DP

更新日期：2020-10-07 00:00:00

abstract：OBJECTIVES:To document the extent to which maternity data are collected and how they are recorded, and to identify problems that may affect their availability throughout the NHS. METHODS:Postal survey in September 1997 with structured questionnaires. SETTING:207 NHS trusts with maternity units in England. PARTICIPAN...

journal_title：BMJ (Clinical research ed.)

authors： Kenney N,Macfarlane A

更新日期：1999-09-04 00:00:00

abstract：:Physicians need to evaluate clinical research critically, and determining the power of a study is an essential component of research evaluation. This report presents a graphical aid that permits rapid power determination for clinical trials with two groups. Power curves were developed for dichotomous outcomes by setti...

journal_title：BMJ (Clinical research ed.)

authors： Miller DK,Homan SM

更新日期：1988-09-10 00:00:00

abstract：OBJECTIVE:To examine the relation between diameters of the retinal arterioles and 10 year incidence of hypertension. DESIGN:Population based prospective cohort study. SETTING:Beaver Dam eye study. PARTICIPANTS:2451 normotensive people aged 43 to 84 years. MAIN OUTCOME MEASURES:Diameters of retinal arterioles and ve...

journal_title：BMJ (Clinical research ed.)

authors： Wong TY,Shankar A,Klein R,Klein BE,Hubbard LD

更新日期：2004-07-10 00:00:00

abstract：OBJECTIVE:To determine whether inhaled salmeterol, a new long acting inhaled beta adrenergic agonist, reduces nocturnal bronchoconstriction and improves sleep quality in patients with nocturnal asthma. DESIGN:Randomised, double blind, placebo controlled crossover study. SETTING:Hospital outpatient clinics in Edinburg...

journal_title：BMJ (Clinical research ed.)

authors： Fitzpatrick MF,Mackay T,Driver H,Douglas NJ

更新日期：1990-12-15 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of an integrated care programme, combining a patient directed and a workplace directed intervention, for patients with chronic low back pain. DESIGN:Population based randomised controlled trial. SETTING:Primary care (10 physiotherapy practices, one occupational health service, ...

journal_title：BMJ (Clinical research ed.)

authors： Lambeek LC,van Mechelen W,Knol DL,Loisel P,Anema JR

更新日期：2010-03-16 00:00:00

abstract：OBJECTIVE:To evaluate dynamic contrast enhanced computed tomography for detecting and localising pancreatic necrosis in acute pancreatitis. DESIGN:Prospective evaluation with blind reporting of scans. SETTING:Single teaching hospital. PATIENTS:60 Consecutive patients with acute pancreatitis suspected to have pancrea...

journal_title：BMJ (Clinical research ed.)

authors： Larvin M,Chalmers AG,McMahon MJ

更新日期：1990-06-02 00:00:00

abstract：OBJECTIVE:To investigate the facilities for inpatient care of mentally disordered people in prison. DESIGN:Semistructured inspections conducted by doctor and nurse. Expected standards were based on healthcare quality standards published by the Prison Service or the NHS. SETTING:13 prisons with inpatient beds in Engla...

journal_title：BMJ (Clinical research ed.)

authors： Reed JL,Lyne M

更新日期：2000-04-15 00:00:00

abstract：OBJECTIVES:To review completed trials assessing effect of hormone replacement therapy on subsequent risk of stroke, assessing stroke by pathological type, severity, and outcome. DESIGN:Systematic review of randomised controlled trials identified from the Cochrane Library, Embase, and Medline; reviews; and reference li...

journal_title：BMJ (Clinical research ed.)

authors： Bath PM,Gray LJ

更新日期：2005-02-12 00:00:00

abstract：OBJECTIVES:To evaluate the cardiac safety of central nervous system stimulants in children and adolescents. DESIGN:Population based retrospective cohort study. SETTING:Automated healthcare claims data from 1,219,847 children and young people eligible for 28 state Medicaid programmes from 1999 to 2006 linked to the So...

journal_title：BMJ (Clinical research ed.)

authors： Winterstein AG,Gerhard T,Kubilis P,Saidi A,Linden S,Crystal S,Zito J,Shuster JJ,Olfson M

更新日期：2012-07-18 00:00:00

abstract：OBJECTIVE:To compare the rate of moderate to severe exacerbations between triple therapy and dual therapy or monotherapy in patients with chronic obstructive pulmonary disease (COPD). DESIGN:Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES:PubMed, Embase, Cochrane databases, and clini...

journal_title：BMJ (Clinical research ed.)

authors： Zheng Y,Zhu J,Liu Y,Lai W,Lin C,Qiu K,Wu J,Yao W

更新日期：2018-11-06 00:00:00

abstract：OBJECTIVE:To compare ultrasonography with intravenous urography in the investigation of adults with haematuria. DESIGN:Prospective study entailing the examination of all patients with both investigations concurrently. The investigations were performed independently on routine lists by different duty radiologists. Each...

journal_title：BMJ (Clinical research ed.)

authors： Spencer J,Lindsell D,Mastorakou I

更新日期：1990-11-10 00:00:00

abstract：OBJECTIVE:To describe the current methods used by English medical schools to identify prospective medical students for admission to the five year degree course. DESIGN:Review study including documentary analysis and interviews with admissions tutors. SETTING:All schools (n = 22) participating in the national expansio...

journal_title：BMJ (Clinical research ed.)

authors： Parry J,Mathers J,Stevens A,Parsons A,Lilford R,Spurgeon P,Thomas H

更新日期：2006-04-29 00:00:00

abstract：OBJECTIVES:To investigate potential determinants of severe hypoglycaemia, including baseline characteristics, in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial and the association of severe hypoglycaemia with levels of glycated haemoglobin (haemoglobin A(1C)) achieved during therapy. DESIGN:Post ...

journal_title：BMJ (Clinical research ed.)

authors： Miller ME,Bonds DE,Gerstein HC,Seaquist ER,Bergenstal RM,Calles-Escandon J,Childress RD,Craven TE,Cuddihy RM,Dailey G,Feinglos MN,Ismail-Beigi F,Largay JF,O'Connor PJ,Paul T,Savage PJ,Schubart UK,Sood A,Genuth S,ACC

更新日期：2010-01-08 00:00:00

abstract：OBJECTIVE:To examine the associations between neuraxial anaesthesia or general anaesthesia and clinical outcomes, length of hospital stay, and readmission in adults undergoing lower limb revascularisation surgery. DESIGN:Comparative effectiveness study using linked, validated, population based databases. SETTING:Onta...

journal_title：BMJ (Clinical research ed.)

authors： Roberts DJ,Nagpal SK,Kubelik D,Brandys T,Stelfox HT,Lalu MM,Forster AJ,McCartney CJ,McIsaac DI

更新日期：2020-11-25 00:00:00

abstract：OBJECTIVE:To study delays between sending referral letters and the outpatient appointment and to assess the content of referral and reply letters, their educational value, and the extent to which questions asked are answered by reply letters. DESIGN:Retrospective review of referrals to 16 consultant orthopaedic surgeo...

journal_title：BMJ (Clinical research ed.)

authors： Jacobs LG,Pringle MA

更新日期：1990-09-08 00:00:00

abstract：OBJECTIVE:To do an indirect comparison analysis of apixaban against dabigatran etexilate (2 doses) and rivaroxaban (1 dose), as well as of rivaroxaban against dabigatranetexilate (2 doses), for their relative efficacy and safety against each other, with particular focus on the secondary prevention population for stroke...

journal_title：BMJ (Clinical research ed.)

authors： Rasmussen LH,Larsen TB,Graungaard T,Skjøth F,Lip GY

更新日期：2012-11-05 00:00:00

abstract：:The identification of the gene for cystic fibrosis has led to the possibility of population based screening for carriers of cystic fibrosis to identify couples at risk of having an affected child. Pilot studies have shown that screening is feasible and does not cause untoward anxiety, though the uptake of testing vari...

journal_title：BMJ (Clinical research ed.)

authors： Modell M

更新日期：1993-10-02 00:00:00

abstract：OBJECTIVE:To determine the relative contribution of decline in bone density to the increase in risk of hip fracture with age in men and women. DESIGN:Incidence data of hip fracture from the general population were combined with the bone density distribution in a sample from the same population and with a risk estimate...

journal_title：BMJ (Clinical research ed.)

authors： De Laet CE,van Hout BA,Burger H,Hofman A,Pols HA

更新日期：1997-07-26 00:00:00

abstract：OBJECTIVE:To examine variations in teenage pregnancy rates in Trent region and to determine possible associations with local general practice characteristics such as the age and sex of the doctors. DESIGN:Cross sectional survey. SETTING:All 826 general practices in Trent region in existence between 1994 and 1997. SU...

journal_title：BMJ (Clinical research ed.)

authors： Hippisley-Cox J,Allen J,Pringle M,Ebdon D,McPhearson M,Churchill D,Bradley S

更新日期：2000-03-25 00:00:00

abstract：OBJECTIVE:To assess the effects of social deprivation on survival after cardiac surgery and to examine the influence of potentially modifiable risk factors. DESIGN:Analysis of prospectively collected data. Prognostic models used to examine the additional effect of social deprivation on the end points. SETTING:Birming...

journal_title：BMJ (Clinical research ed.)

authors： Pagano D,Freemantle N,Bridgewater B,Howell N,Ray D,Jackson M,Fabri BM,Au J,Keenan D,Kirkup B,Keogh BE,Quality and Outcomes Research Unit (QuORU) UHB Birmingham.,North West Quality Improvement Programme in Cardiac Interventions (U

更新日期：2009-04-02 00:00:00