Association between depression and insomnia subtypes: a longitudinal study on the elderly in Japan.


STUDY OBJECTIVE:To examine the association between depression and three subtypes of insomnia, namely, difficulty initiating sleep (DIS), early morning awakening (EMA), and difficulty maintaining sleep (DMS). DESIGN:Cross-sectional and longitudinal study. SETTING:Community dwellers in Japan. PARTICIPANTS:Nationally representative samples of adults aged 65 and over (total N=4,997) were selected by a multistage stratified random sampling method in 1999 and were interviewed face-to-face in 1999, 2001, 2003, and 2006. Those who responded to the 3rd survey conducted in 2003 and the 4th survey conducted in 2006 were used in this study. MEASUREMENT AND RESULTS:Depression was evaluated according to the 11-item short form of the CES-D scale at 2 points in time. Insomnia subtypes were assessed by self-reported measures. A logistic regression was employed to examine the association between insomnia subtypes and the presence of depression, controlling for relevant factors. A cross-sectional analysis based on the 2003 data demonstrated statistically significant odds ratios (ORs) for DIS and EMA. In the longitudinal study, DIS at the time of the 3rd survey was found to be significantly related to the presence of depression at the time of the 4th survey, with an odds ratio (95%CI) of 1.592 (1.012 to 2.504). EMA (OR 1.070; 95% CI, 0.664 to 1.723) and DMS (OR 1.215; 95% CI, 0.860 to 1.716), however, were not found to be significantly related to the presence of depression. CONCLUSION:The longitudinal study revealed a statistically significant relationship, controlling for other relevant factors, between DIS and the presence of depression three years later, but not between EMA or DMS and depression. Based on our findings, we recommend that the association between insomnia subtypes and depression be studied longitudinally in clinical settings.






Yokoyama E,Kaneita Y,Saito Y,Uchiyama M,Matsuzaki Y,Tamaki T,Munezawa T,Ohida T




Has Abstract


2010-12-01 00:00:00














  • Myofunctional Therapy to Treat Obstructive Sleep Apnea: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVE:To systematically review the literature for articles evaluating myofunctional therapy (MT) as treatment for obstructive sleep apnea (OSA) in children and adults and to perform a meta-analysis on the polysomnographic, snoring, and sleepiness data. DATA SOURCES:Web of Science, Scopus, MEDLINE, and The Cochrane...


    pub_type: 杂志文章,meta分析,评审


    authors: Camacho M,Certal V,Abdullatif J,Zaghi S,Ruoff CM,Capasso R,Kushida CA

    更新日期:2015-05-01 00:00:00

  • Paradoxical sleep rebound without previous debt: the effect of minute doses of clonidine in man.

    abstract::This report describes an experimental condition in which clonidine administration does not modify paradoxical sleep (PS) directly, but is followed by a secondary rebound. After oral consumption of minute doses of clonidine (CLN), 12 subjects showed no direct effect of CLN, but showed a significant increase of PS produ...


    pub_type: 杂志文章


    authors: Gaillard JM,Iorio G,Kafi S,Blois R

    更新日期:1983-01-01 00:00:00

  • Evaluation of treatment with stimulants in narcolepsy.

    abstract::This paper briefly reviews sleep laboratory studies on the treatment efficacy of methylphenidate, pemoline, dextroamphetamine and methamphetamine. The literature indicates that 1) methylphenidate, dextroamphetamine, pemoline and methamphetamine objectively improve somnolence as measured by the Multiple Sleep Latency o...


    pub_type: 杂志文章


    authors: Mitler MM

    更新日期:1994-12-01 00:00:00

  • Effects of eszopiclone and zolpidem on sleep and waking states in the adult guinea pig.

    abstract:STUDY OBJECTIVE:The present study was designed to compare and contrast the effects of eszopiclone and zolpidem on the states of sleep and wakefulness in chronically instrumented, unanesthetized adult guinea pigs. DESIGN:Adult guinea pigs were implanted with electrodes to record sleep and waking states and to perform a...


    pub_type: 杂志文章


    authors: Xi M,Chase MH

    更新日期:2008-07-01 00:00:00

  • Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration.

    abstract:STUDY OBJECTIVES:The main energy reserve of the brain is glycogen, which is almost exclusively localized in astrocytes. We previously reported that cerebral expression of certain genes related to glycogen metabolism changed following instrumental sleep deprivation in mice. Here, we extended our investigations to anothe...


    pub_type: 杂志文章


    authors: Petit JM,Tobler I,Kopp C,Morgenthaler F,Borbély AA,Magistretti PJ

    更新日期:2010-07-01 00:00:00

  • Sleep apnea and hypertension--what a mess!

    abstract::It is unarguable that obstructive sleep apnea (OSA) causes pulsatile hypertension during sleep, but whether there is significant carryover of hypertension into waking hours is far from clear. It is perhaps more useful to consider whether OSA is related to the consequences of hypertension (e.g. stroke), since both noct...


    pub_type: 杂志文章,评审


    authors: Stradling J,Davies RJ

    更新日期:1997-09-01 00:00:00

  • Prenatal origins of poor sleep in children.

    abstract:STUDY OBJECTIVES:We examined whether small body size at birth and prenatal tobacco or alcohol exposure predict poor sleep and more sleep disturbances in children. DESIGN:An epidemiologic cohort study of 289 eight-year-old children born at term. MEASUREMENTS AND RESULTS:Sleep duration and efficiency were measured by a...


    pub_type: 杂志文章


    authors: Pesonen AK,Räikkönen K,Matthews K,Heinonen K,Paavonen JE,Lahti J,Komsi N,Lemola S,Järvenpää AL,Kajantie E,Strandberg T

    更新日期:2009-08-01 00:00:00

  • Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis.

    abstract:STUDY OBJECTIVES:The sleep-deprivation-induced changes in delta power, an electroencephalographical correlate of sleep need, and brain transcriptome profiles have importantly contributed to current hypotheses on sleep function. Because sleep deprivation also induces stress, we here determined the contribution of the co...


    pub_type: 杂志文章


    authors: Mongrain V,Hernandez SA,Pradervand S,Dorsaz S,Curie T,Hagiwara G,Gip P,Heller HC,Franken P

    更新日期:2010-09-01 00:00:00

  • Dexmedetomidine Induced Deep Sedation Mimics Non-Rapid Eye Movement Stage 3 Sleep: Large Scale Validation using Machine Learning.

    abstract:STUDY OBJECTIVES:Dexmedetomidine induced electroencephalogram (EEG) patterns during deep sedation is comparable with natural sleep patterns. Using large scale EEG recordings and machine learning techniques, we investigated whether dexmedetomidine induced deep sedation indeed mimics natural sleep patterns. METHODS:We u...


    pub_type: 杂志文章


    authors: M Ramaswamy S,Weerink MAS,Struys MMRF,B Nagaraj S

    更新日期:2020-08-29 00:00:00

  • Prevalence of persistent sleep apnea in patients treated with continuous positive airway pressure.

    abstract:STUDY OBJECTIVE:There are limited data on the prevalence of persistent obstructive sleep apnea (OSA) in patients who are clinically asymptomatic with continuous positive airway pressure (CPAP). Our objectives were to estimate the prevalence of persistent OSA and to explore the parameters that may be capable of discrimi...


    pub_type: 杂志文章


    authors: Baltzan MA,Kassissia I,Elkholi O,Palayew M,Dabrusin R,Wolkove N

    更新日期:2006-04-01 00:00:00

  • Auditory inhibition of rapid eye movements and dream recall from REM sleep.

    abstract:STUDY OBJECTIVES:There is debate in dream research as to whether ponto-geniculo-occipital (PGO) waves or cortical arousal during sleep underlie the biological mechanisms of dreaming. This study comprised 2 experiments. As eye movements (EMs) are currently considered the best noninvasive indicator of PGO burst activity ...


    pub_type: 杂志文章


    authors: Stuart K,Conduit R

    更新日期:2009-03-01 00:00:00

  • Symptoms of attention-deficit/hyperactivity disorder in adults with restless legs syndrome.

    abstract:OBJECTIVE:To determine the occurrence of symptoms of attention-deficit/hyperactivity disorder (ADHD) in adults with restless legs syndrome (RLS), normal controls, and controls with insomnia. SETTING:University-based hospital. METHODS:The occurrence and severity of current ADHD symptoms were determined in a prospectiv...


    pub_type: 杂志文章


    authors: Wagner ML,Walters AS,Fisher BC

    更新日期:2004-12-15 00:00:00

  • Early Blood Lead Levels and Sleep Disturbance in Preadolescence.

    abstract:STUDY OBJECTIVES:Little is known about the effect of lead exposure on children's sleep. This study examined the association between blood lead levels (BLL) and sleep problems in a longitudinal study of children. SETTING:Four community-based elementary schools in Jintan City, China. PARTICIPANTS:1,419 Chinese children...


    pub_type: 杂志文章


    authors: Liu J,Liu X,Pak V,Wang Y,Yan C,Pinto-Martin J,Dinges D

    更新日期:2015-12-01 00:00:00

  • The Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea.

    abstract:STUDY OBJECTIVE:To test the hypothesis that respiratory event duration exhibits an endogenous circadian rhythm. DESIGN:Within-subject and between-subjects. SETTINGS:Inpatient intensive physiologic monitoring unit at the Brigham and Women's Hospital. PARTICIPANTS:Seven subjects with moderate/severe sleep apnea and fo...


    pub_type: 杂志文章


    authors: Butler MP,Smales C,Wu H,Hussain MV,Mohamed YA,Morimoto M,Shea SA

    更新日期:2015-11-01 00:00:00

  • Effects of CPAP on vigilance and related functions in patients with the sleep apnea/hypopnea syndrome.

    abstract::There have been relatively few robust studies of the effects of CPAP therapy on vigilance and daytime function. This article will use all known published and unpublished randomized clinical trials on this area. There is good evidence that CPAP helps subjective sleepiness, objective sleepiness, quality of life, mood an...


    pub_type: 杂志文章,评审


    authors: Douglas NJ,Engleman HM

    更新日期:2000-06-15 00:00:00

  • Changes in the waking EEG as a consequence of sleep and sleep deprivation.

    abstract::Electroencephalographic (EEG) activity was monopolarly recorded during resting wakefulness in 10 volunteers under the following conditions: at night before going to sleep, at night before total sleep deprivation, in the morning after waking, in the morning after sleep deprivation and at night after having slept during...


    pub_type: 杂志文章


    authors: Corsi-Cabrera M,Ramos J,Arce C,Guevara MA,Ponce-de León M,Lorenzo I

    更新日期:1992-12-01 00:00:00

  • Heritability of insomnia symptoms in youth and their relationship to depression and anxiety.

    abstract:STUDY OBJECTIVES:Insomnia is a highly prevalent sleep disorder yet little is known about the role of genetic factors in its pathophysiology. The aim of this study was to examine the relative contributions of genetic and environmental factors in explaining variability in insomnia symptoms. DESIGN:Traditional twin desig...


    pub_type: 杂志文章


    authors: Gehrman PR,Meltzer LJ,Moore M,Pack AI,Perlis ML,Eaves LJ,Silberg JL

    更新日期:2011-12-01 00:00:00

  • Endozepine stupor: disease or deception? A critical review.

    abstract::Presentation of patients with recurrent stupor associated with apparently elevated levels of an endogenous benzodiazepine-like agent, endozepine-4, has been reported from several centers, and a new syndrome, endozepine stupor has been proposed. We recently reported a case with typical features of this syndrome, which ...


    pub_type: 杂志文章,评审


    authors: Granot R,Berkovic SF,Patterson S,Hopwood M,Drummer OH,Mackenzie R

    更新日期:2004-12-15 00:00:00

  • Differences in insulin secretion and sensitivity in short-sleep insomnia.

    abstract:OBJECTIVE:Short-sleep insomnia is associated with increased risk of diabetes. The role of altered insulin secretion and action in this association is poorly understood. DESIGN:Observational study. SETTING:Academic clinical research center. PARTICIPANTS:Nondiabetic individuals with insomnia (mean [standard deviation]...


    pub_type: 杂志文章


    authors: Vasisht KP,Kessler LE,Booth JN 3rd,Imperial JG,Penev PD

    更新日期:2013-06-01 00:00:00

  • Significance and treatment of nonapneic snoring.

    abstract::Snoring has been associated with an increased risk of vascular morbidity and mortality and with the complaint of excessive daytime sleepiness. Much of this risk may be attributable to concomitant sleep apnea or hypopnea. Recent work suggests that in certain individuals, snoring without apnea or hypopnea can lead to sl...


    pub_type: 杂志文章


    authors: Strollo PJ Jr,Sanders MH

    更新日期:1993-08-01 00:00:00

  • Practice parameters for the use of stimulants in the treatment of narcolepsy. Standards of Practice Committee of the American Sleep Disorders Association.

    abstract::Narcolepsy is a disorder of the central nervous system characterized by excessive sleepiness, cataplexy, and other rapid-eye-movement (REM)-sleep phenomena such as sleep paralysis and hypnagogic hallucinations. Although stimulants are the only effective treatment for the sleepiness of narcolepsy, no clinical guideline...


    pub_type: 指南,杂志文章,实务指引



    更新日期:1994-06-01 00:00:00

  • Narcolepsy without cataplexy: 2 subtypes based on CSF hypocretin-1/orexin-A findings.

    abstract:STUDY OBJECTIVES:Cerebrospinal fluid (CSF) hypocretin-1 levels and their relationship with the clinical characteristics of narcolepsy without cataplexy have not been well elucidated. Our aim was to examine whether clinical characteristics vary with CSF hypocretin-1 levels among narcoleptic patients without cataplexy. ...


    pub_type: 杂志文章


    authors: Oka Y,Inoue Y,Kanbayashi T,Kuroda K,Miyamoto M,Miyamoto T,Ikeda A,Shimizu T,Hishikawa Y,Shibasaki H

    更新日期:2006-11-01 00:00:00

  • Respiratory monitoring in sleep apnea syndrome.

    abstract::This review provides a critical analysis of current respiratory monitoring techniques in diagnosis of sleep apnea syndrome. The correct analysis of polysomnography requires knowledge of the limitations of the means of recording used. These limitations, for invasive and noninvasive techniques, are discussed in terms of...


    pub_type: 杂志文章,评审


    authors: Lévy P,Pépin JL,Wuyam B,Veale D

    更新日期:1992-12-01 00:00:00

  • Antibodies Against Hypocretin Receptor 2 Are Rare in Narcolepsy.

    abstract:Study Objectives:Recently, antibodies to the hypocretin receptor 2 (HCRTR2-Abs) were reported in a high proportion of narcolepsy patients who developed the disease following Pandemrix® vaccination. We tested a group of narcolepsy patients for the HCRTR2-Abs using a newly established cell-based assay. Methods:Sera from...


    pub_type: 杂志文章


    authors: Giannoccaro MP,Waters P,Pizza F,Liguori R,Plazzi G,Vincent A

    更新日期:2017-02-01 00:00:00

  • Behavioral interventions for pediatric insomnia: one treatment may not fit all.

    abstract:STUDY OBJECTIVES:Behavioral interventions for pediatric insomnia are cost-effective and benefit most families, but there is no evidence indicating which treatments are most suitable for specific patient populations. This randomized controlled trial evaluated the moderating role of infant separation anxiety in two brief...


    pub_type: 杂志文章


    authors: Kahn M,Juda-Hanael M,Livne-Karp E,Tikotzky L,Anders TF,Sadeh A

    更新日期:2020-04-15 00:00:00

  • A method for checking interobserver reliability in observational sleep studies.

    abstract::Disturbances of the sleep/wake cycle occur frequently in nursing home residents. Because of the many technical difficulties in studying sleep and rhythms in such patients, systematic behavioral observations offer an alternative approach. In this study we describe a method for determining interrater reliability of such...


    pub_type: 杂志文章


    authors: Carroll JS,Bliwise DL,Dement WC

    更新日期:1989-08-01 00:00:00

  • The association between short sleep duration and obesity in young adults: a 13-year prospective study.

    abstract:STUDY OBJECTIVES:Obesity has become a major health problem with increasing prevalence. Given the limited availability of effective treatment of weight problems, the identification of potentially modifiable risk factors may lead to preventive approaches to obesity. The objective of this study was to test the hypothesis ...


    pub_type: 杂志文章


    authors: Hasler G,Buysse DJ,Klaghofer R,Gamma A,Ajdacic V,Eich D,Rössler W,Angst J

    更新日期:2004-06-15 00:00:00

  • Minute-by-minute association of heart rate variation with basal heart rate in developing infants.

    abstract::Particular types of heart rate variation are enhanced during periods of slow heart rate and diminished when heart rate is high. We examined how the correlations between heart rate and various types of heart rate variation developed in normal infants. Polygraphic recordings were obtained from 25 infants at 1 week and a...


    pub_type: 杂志文章


    authors: Schechtman VL,Harper RM

    更新日期:1993-01-01 00:00:00

  • Arterial stiffness increases during obstructive sleep apneas.

    abstract:STUDY OBJECTIVES:Obstructive sleep apnea (OSA) appears to be an independent risk factor for diurnal systemic hypertension, but the specific biologic markers for this association have not been well established. Increased arterial stiffness is an important measure of increased left ventricular load and a predictor of car...


    pub_type: 杂志文章


    authors: Jelic S,Bartels MN,Mateika JH,Ngai P,DeMeersman RE,Basner RC

    更新日期:2002-12-01 00:00:00

  • Quantification of penile "buckling" force.

    abstract::A hand-held transducer was developed for measuring penile rigidity. This instrument gives a quantitative measure of the force at which the penis "buckles." The transducer consists of a cantilever beam with strain gages that is rugged, easy to calibrate, and adaptable to most graphic recorders. ...


    pub_type: 杂志文章


    authors: Hahn PM,Leder R

    更新日期:1980-01-01 00:00:00