Abstract：
:Antioxidant, antitumor and anticarcinogenic activity of gossypin (3,5,8,3',4'-pentahydroxy-7-O glucosyl flavone) was carried out. The compound needed for 50% inhibition of superoxide, hydroxyl and nitric oxide radicals was 3 microg/ml, 41 microg/ml and 12 microg/ml, respectively. Gossypin also impart 50% inhibition at concentrations 37 microg/ml and 43 microg/ml, respectively for in vitro lipid peroxidation. The compound shows IC50 of 30 microM, 42.5 microM and 45.1 microM concentrations in L 929, HT 29 and K 562 cell lines in 72 hrs MTT assay. The compound shows a zone of inhibition of 8 mm in topo I and topo II inhibition assay in Saccharomyces ceriviseae mutant cultures. It reduces the tumor burden in solid tumor harboring animals (p < 0.001) and effectively inhibits the formation of new blood vessels on tumor mass. 20 mg/kg b.wt of gossypin increase the life span of ascites tumor harboring animals (100%) and (164.7%) respectively by oral and intraperitoneal administration of the drug. Gossypin reduced the incidence of papilloma formation and papilloma/mouse in DMBA/ croton oil induced skin papilloma.
journal_name
J Exp Clin Cancer Resjournal_title
Journal of experimental & clinical cancer research : CRauthors
Babu BH,Jayram HN,Nair MG,Ajaikumar KB,Padikkala Jkeywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
581-9issue
4eissn
0392-9078issn
1756-9966journal_volume
22pub_type
杂志文章abstract：:An amendment to this paper has been published and can be accessed via the original article. ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,已发布勘误
doi：10.1186/s13046-020-01663-2
更新日期：2020-08-24 00:00:00
abstract：BACKGROUND:Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles a...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-016-0471-3
更新日期：2017-01-05 00:00:00
abstract：BACKGROUND:The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated these proteins in saliva and their association with the tumor, which may represent potential useful...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-29-40
更新日期：2010-04-29 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities. The paper aims to identify marker genes able to predict an increased risk of l...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 临床试验,杂志文章
doi：10.1186/1756-9966-31-7
更新日期：2012-01-24 00:00:00
abstract：BACKGROUND:Viscum album L. extracts (VAE, European mistletoe) are a widely used medicinal plant extract in gynaecological and breast-cancer treatment. METHODS:Systematic review to evaluate clinical studies and preclinical research on the therapeutic effectiveness and biological effects of VAE on gynaecological and bre...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/1756-9966-28-79
更新日期：2009-06-11 00:00:00
abstract：BACKGROUND:Manganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor activities in various cancers. This study aimed to assess whether isovitexin inhibits hepatic carcinoma stem-like cells (HCSLCs) features via regulating Mn...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1244-6
更新日期：2019-06-17 00:00:00
abstract：:Pseudogene was recognized as a potential tumor suppressor or oncogene in varies of diseases, however its roles in glioma have not been investigated. Our study was to identify the pseudogene-signature that predicted glioma survival. Using a pseudogene-mining approach, we performed pseudogene expression profiling in 183...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-015-0137-6
更新日期：2015-03-04 00:00:00
abstract：:Naphthalmustine, 2-[2-[bis-(2-chloroethyl)amino]ethyl]-1H-benz[de]isoquinoline-1,3-dione (Compound 1) has been synthesized as a rationally designed new anticancer agent from N-(2-bromoethyl)naphthalimide. Its chemical alkylating activity exceeded that of nor-HN2 used as standard compound for comparison. Its antitumour...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:This study was carried out statistically to evaluate the present situation of carcinoids and related endocrine variants in the uterine cervix. A total of 205 patients who had been reported on in world-wide literature were divided into two groups; one, as a carcinoid group, consisting of 81 patients with carcinoids, 49...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:Gastric tissue was transplanted from the fundic and pyloric mucosa of 8-week old female F344 rats into the duodenum of males. Autopsy, 12 months after the operation, revealed grafts associated with persistent stones in the duodenum and/or calcification in the tissue. Pepsinogen positive chimeric glands with goblet cel...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:The primary glioblastoma multiforme (GBM) is the most malignant form of astrocytic tumor with an average survival of approximately 12-14 months. The search for novel and more efficient chemo-agents against this disease is urgent. Salinomycin induces broad anti-cancer effects; however, its role in GBM and the...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-015-0174-1
更新日期：2015-05-30 00:00:00
abstract：:The mutational spectrum of p53 gene and the biological effects of mutant p53 protein vary greatly from one type of tumor to another. To investigate the biological effects of mutant p53 gene in human lung adenocarcinoma, mutant p53 was silenced by RNA interference (RNAi) in cell line Anip973. Then, the effects of mutan...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) remain mostly unknown. METHODS:In this study, quantitative real-time PCR (qPCR) and western blotting ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-020-01633-8
更新日期：2020-07-20 00:00:00
abstract：:Adenosquamous carcinomas of the colorectum are rare neoplasms. Our experience with two cases is presented in this paper. One patient, who complained of bloody stool, was found to have adenocarcinoma in the sigmoid colon. He received a laparoscopy-assisted sigmoidectomy. The histological examination revealed that the t...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive neoplasia with no effective therapy. Our laboratory has developed a unique TNBC cell model presenting epithelial mesenchymal transition (EMT) a process known to be important for tumor progression and metastasis. There is increasing evidence showing that e...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-0988-8
更新日期：2018-12-14 00:00:00
abstract：:RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy receptor osteoprotegerin (OPG). Although this system is critical for the regulation of osteoclast differentia...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/s13046-018-1001-2
更新日期：2019-01-08 00:00:00
abstract：BACKGROUND:Dysregulated endocytosis of membrane proteins contributes significantly to several hallmarks of cancer. Basigin can enhance cancer progression, but its precise mechanism remains unclear. CD98 promotes cell spreading and tumorigenicity by triggering integrin clustering and enhancing cell adhesion to the extra...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-015-0226-6
更新日期：2015-10-06 00:00:00
abstract：BACKGROUND:Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored the exposure of PS on platelets and microparticles (MPs), and evaluate its role in procoagulant activ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-016-0328-9
更新日期：2016-03-25 00:00:00
abstract：:Even though it is well established that oxygen-free radicals are the main mechanism responsible for the cytotoxicity produced during radiotherapy, the role of the human antioxidant defense system in clinical radiation oncology is still to be clarified. Changes in the human plasma total peroxyl radical trapping capacit...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：PURPOSE:There has been no satisfactory treatment for advanced melanoma until now. Targeted radionuclide therapy (TRNT) may be a promising option for this heretofore lethal disease. Our goal in this study was to synthesize 131I-N-(2-(diethylamino)ethyl)-5-(iodo-131I)picolinamide (131I-5-IPN) and evaluate its therapeutic...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-0983-0
更新日期：2018-12-11 00:00:00
abstract：BACKGROUND:Ovarian cancer (OC) is the most lethal gynecological malignancy and the second leading cause of cancer-related death in women. Treatment with PARP inhibitors (PARPi), such as Olaparib, has been recently introduced for OC patients, but resistance may occur and underlying mechanisms are still poorly understood...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-019-1490-7
更新日期：2020-01-02 00:00:00
abstract：:The efficacy of currently developed methods for gene transfer into mammalian cells depends primarily on the transfection technique, and also on the type of targeted cells. Considering the importance of gene transfer in the creation of gene therapies, our study was aimed at the assessment of transfection capacity of re...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:This study was conducted to establish a feasible intraperitoneal xenograft model in nude mice which mimicked the dynamic progression of human ovarian cancer and to explore its potential for preclinical trials. A human ovarian tumor line SKOV3 was originally injected s.c. to develop tumors; then the tumors were harvest...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Osteosarcoma (OS) is a high-grade bone sarcoma with early metastasis potential, and the clinical chemotherapy drugs that are currently used for its treatment have some limitations. Recently, several studies have reported the selective antitumor effect of oleandrin on various tumor cells. In this study, we ai...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-015-0232-8
更新日期：2015-10-06 00:00:00
abstract：BACKGROUND:Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis. MATERIALS AND METHODS:Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal can...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-30-23
更新日期：2011-02-23 00:00:00
abstract：:In the original publication of this manuscript [1], Fig. 1 contained a typographical error ('Metabolic' incorrectly written as 'Metabolig'). ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 已发布勘误
doi：10.1186/s13046-020-1532-1
更新日期：2020-02-24 00:00:00
abstract：:After aggressive surgery and chemotherapy, patients (PTS) with advanced solid tumors have often an impaired immune function that may facilitate tumor relapse. We have demonstrated, in a phase IB study, that administering low-dose interleukin-2 (IL-2) and 13-cis retinoic acid (RA), there was a significant improvement o...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molecular mechanism. METHODS:The changes of macrophage phenotypes after P...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-020-01786-6
更新日期：2021-01-04 00:00:00
abstract：BACKGROUND:Yes-associated protein (YAP), an essential component of Hippo pathway, was identified as an oncoprotein which participated in the progression of various malignancies. However, its role in chronic myeloid leukemia (CML) remains to be further clarified. METHODS:The expression of YAP in CML cells was determine...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-016-0414-z
更新日期：2016-09-06 00:00:00
abstract：:Arsenic trioxide has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukemia (APL) as well as solid tumors. Arsenic can act through a considerable number of different pathways including mitochondrial respiration and tubulin formation, affecting growth, blood flow, diffe...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
