当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > Colonic polyps of acromegalic patients are not associated with mutations of the peroxisome proliferator activated receptor gamma gene.

Colonic polyps of acromegalic patients are not associated with mutations of the peroxisome proliferator activated receptor gamma gene.

Abstract：

:Peroxisome proliferator activated receptor (PPAR)gamma plays a pivotal role in regulating adipocyte differentiation and metabolism, but also has an antiproliferative effect in several tissues, including colonic mucosa, where it is highly expressed. Loss-of-function mutations have been reported in about 10% of sporadic primary colon cancer. Acromegalic patients have an increased prevalence of colonic neoplasms and lower PPARgamma levels in the colonic mucosa. Thus, PPARgamma may act as a tumor suppressor gene, and its reduced expression or loss-of-function mutations may contribute to tumorigenesis. In this study the expression and mutations of the PPARgamma gene in the colonic polyps and mucosa outside polyps were investigated in 10 acromegalic and 17 non-acromegalic patients. PPARgamma expression was evaluated by RT-PCR. PPARgamma was expressed in each sample, but expression appeared to be lower in polyps than in mucosa outside polyps from either acromegalic or non-acromegalic patients. All exons of the PPARgamma gene were directly sequenced after PCR amplification: no mutations were found either in acromegalic or in non-acromegalic patients. In conclusion, the results of this preliminary study suggest that the lower expression of PPARgamma rather than somatic mutations of this gene is involved in colonic tumorigenesis.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Bogazzi F,Ultimieri F,Raggi F,Russo D,Brogioni S,Cosci C,Gasperi M,Costa A,Viacava P,Mosca F,Bartalena L,Martino E

doi

10.1007/BF03345249

keywords:

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

1054-8

issue

11

eissn

0391-4097

issn

1720-8386

pii

5488

journal_volume

26

pub_type

杂志文章

相关文献

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION文献大全
  • Use of granulosa-luteal cell culture to evaluate low and high clinical responses to menotropin stimulation.

    abstract：:The cause of a poor response to human menopausal gonadotropin (hMG) remains unexplained. To determine whether aromatase activity of cultured granulosa cells obtained from relatively low estradiol (E2) responders (serum E2 < 1000 pg/ml) to hMG therapy differed from that of good responders (E2 > or = 1000 pg/ml), we pro...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03344926

    authors： Hurst BS,Zacur HA,Schlaff WD,Berkovitz GD

    更新日期：1992-09-01 00:00:00

  • Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects.

    abstract：AIM:In the last years there has been a progressive reduction of the average duration of sleep and an increase in the incidence of sleep disturbances. At the same time, an increase of the incidence of the metabolic syndrome has been described, partly attributable to the progressive worsening of dietary habits and the in...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40618-013-0016-y

    authors： Gramaglia E,Ramella Gigliardi V,Olivetti I,Tomelini M,Belcastro S,Calvi E,Dotta A,Ghigo E,Benso A,Broglio F

    更新日期：2014-02-01 00:00:00

  • Positive association of serum interleukin-1beta and CRH levels in women with pre-term labor.

    abstract：OBJECTIVE:The aim of this study was to investigate the hypothesis that interleukin-1beta (IL-1beta) might be involved in the increase of the circulating levels of placental-derived CRH leading to the initiation of pre-term labor. SUBJECTS AND METHODS:Forty-eight primigravidae with a singleton viable pregnancy between ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347393

    authors： Vitoratos N,Mastorakos G,Kountouris A,Papadias K,Creatsas G

    更新日期：2007-01-01 00:00:00

  • Effects of naloxone on adrenal cortex regulation in patients with primary aldosteronism.

    abstract：:Excess production of proopiomelanocortin (POMC)-derived peptides with aldosterone-stimulating activity has been suggested to play a pathogenetic role in idiopathic hyperaldosteronism (IHA). To further investigate this issue, the opiate receptor antagonist naloxone was administered to 14 patients with primary aldostero...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350149

    authors： Fallo F,Boscaro M,Sonino N,Mantero F

    更新日期：1988-04-01 00:00:00

  • Effect of maternal nicotine/thiocyanate exposure during gestational period upon pituitary, thyroid and parathyroid function/morphology of 1-month-old rat offspring.

    abstract：INTRODUCTION:Impact of in utero exposure to nicotine, on the structure of the thyroid-pituitary axis and the parathyroid glands have been examined in 1-month-old rats and compared with that of thiocyanate. MATERIALS AND METHODS:Three pregnant female groups were used; control, nicotine and thiocyanate. Treatment starte...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-013-0043-8

    authors： Abdelhafez AM,Eltony SA,Abdelhameed SY,Elgayar SA

    更新日期：2014-05-01 00:00:00

  • Predictors of electrocardiographic abnormalities in type 1 Diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy.

    abstract：PURPOSE:To determine the incidence and determinants of developing abnormalities on the 12-lead electrocardiogram (ECG) in persons with type 1 diabetes. METHODS:We evaluated the distribution of ECG abnormalities and risk factors for developing new abnormalities in 266 (mean age = 44 years ± 9.0; 50 % female) people wit...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-016-0564-z

    authors： O'Neal WT,Lee KE,Soliman EZ,Klein R,Klein BE

    更新日期：2017-03-01 00:00:00

  • Markers of activation of coagulation and fibrinolysis in patients with Cushing's syndrome.

    abstract：:Patients with active Cushing's syndrome have an increased thrombotic tendency. We chose to reassess the mechanism underlying the thrombophilic state associated with this clinical condition using sensitive markers of coagulation and fibrinolysis activation in 17 patients with active disease. The results were compared w...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF03343697

    authors： Fatti LM,Bottasso B,Invitti C,Coppola R,Cavagnini F,Mannucci PM

    更新日期：2000-03-01 00:00:00

  • Usefulness of a chromatographic method to detect circulating antithyroid hormone autoantibodies in canine serum.

    abstract：:Antithyroid hormone autoantibodies (THBA), described in both humans and animals, result in variable interference when thyroid hormone plasma levels are measured by immunoassays. We previously described a quick chromatographic method to detect circulating THBA in humans. In the present experience, we applied the method...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347880

    authors： Savastano S,Tommaselli AP,Valentino R,Dorato M,Scarpitta MT,Persechino A,Ciaramella P,Lombardi G

    更新日期：1996-12-01 00:00:00

  • Efficacy of long-term growth hormone therapy in short children with reduced growth hormone biological activity.

    abstract：AIM:The optimal GH regimen, in terms of cost-effectiveness, in children with normal GH immunoreactivity but reduced bioactivity is still debated. METHODS:In 12 GH-deficient (GHD) and 12 bioinactive GH children undergoing GH treatment we evaluated the increase in growth velocity, the difference between target height an...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347461

    authors： Pagani S,Meazza C,Laarej K,Cantoni F,Bozzola M

    更新日期：2011-05-01 00:00:00

  • Cardiovascular risk engines can help in selecting patients to be evaluated by dynamic penile color doppler ultrasound.

    abstract：:General dynamic penile color doppler ultrasound (D-PCDU) screening in patients with erectile dysfunction (ED) has been questioned due to an inadequate cost-benefit ratio. The aim of the present study is to evaluate the validity of different risk scores in the identification of patients being screened for arteriogenic ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345652

    authors： Corona G,Mannucci E,Fisher AD,Lotti F,Bandini E,Vignozzi L,Balercia G,Paggi F,Petrone L,Forti G,Maggi M

    更新日期：2008-12-01 00:00:00

  • Regulation of mouse placental lactogen secretion by G proteins before midpregnancy.

    abstract：:To determine whether G proteins are involved in the regulation of mouse placental lactogen-I (mPL-I) and/or mPL-II secretion before midpregnancy, mouse placental tissue from day 7 of pregnancy was dispersed with collagenase, cells were fractionated on a percoll gradient, and the purified trophoblast cells were culture...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349006

    authors： Yamaguchi M,Miyake A

    更新日期：1996-09-01 00:00:00

  • Comparison of single and combined tests for the evaluation of plasma growth hormone secretion in normal short children.

    abstract：:Growth hormone (GH) response to provocative tests was compared in normal short children. Seven of 23 children failed to respond to insulin hypoglycemia. Using insulin hypoglycemia followed by L-dopa only 2 of 23 children did not respond and giving bromocriptine combined with insulin hypoglycemia only 1 of 8 children f...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03351005

    authors： Bazán MC,Domené H,Heinrich JJ,Barontini M,Bergadá C

    更新日期：1984-08-01 00:00:00

  • Serum levels of adipokines in gestational diabetes: a systematic review.

    abstract：OBJECTIVE:To determine the difference of serum levels of 10 adipokines (apelin, chemerin, fatty acid-binding protein-4, fibroblast growth factor-21, monocyte chemoattractant protein-1, nesfatin-1, omentin-1, resistin, vaspin, and visfatin) among women with gestational diabetes and healthy pregnant controls. MATERIALS ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-018-0973-2

    authors： Bellos I,Fitrou G,Pergialiotis V,Perrea DN,Daskalakis G

    更新日期：2019-06-01 00:00:00

  • Interrelationships between follicle stimulating hormone and the growth hormone--insulin-like growth factor--IGF-binding proteins axes in human granulosa cells in culture.

    abstract：:As it has been hypothesized that IGF-binding proteins (IGFBPs) may have a role as autocrine/paracrine factors in regulating the local actions of the insulin-like growth factors (IGFs) in the ovary, we studied the production of the IGFBPs by human granulosa cells (GC) in culture and the role of IGFBP-3 in the modulatio...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347856

    authors： Barreca A,Artini PG,Cesarone A,Arvigo M,D'Ambrogio G,Genazzani AR,Giordano G,Minuto F

    更新日期：1996-01-01 00:00:00

  • Spontaneous growth hormone and somatomedin-C/insulin-like growth factor-I secretion in obese subjects during puberty.

    abstract：:It has been reported that adult obese subjects present a reduced growth hormone secretion. As no data are available in the pubertal period, which is characterized in lean subjects by an increased spontaneous growth hormone secretion, the growth hormone circadian concentration was studied in a group of 18 obese male su...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350166

    authors： Minuto F,Barreca A,Del Monte P,Fortini P,Resentini M,Morabito F,Giordano G

    更新日期：1988-07-01 00:00:00

  • Recombinant matrix metalloproteinase-14 catalytic domain induces apoptosis in human osteoblastic SaOS-2 cells.

    abstract：:Our study previously showed that estrogen and progesterone stimulated the production of matrix metalloproteinase-14 [MMP-14, or also named membrane type matrix metalloproteinses-1 (MT1-MMP)] in osteoblastic cells. MMP-14 was implied to regulate the function of osteoblasts by degrading bone matrix or growth factors, bu...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345259

    authors： Luo XH,Liao EY,Liao HJ,Jin Y,Zhou HD,Huang G

    更新日期：2003-11-01 00:00:00

  • Psychobiology of facial attractiveness.

    abstract：:The last decade has witnessed an upsurge of interest in the research on facial attractiveness. The development of computer graphics has allowed to objectively investigate the conserved features of attractive faces. Averageness, symmetry and sex-specific traits have been associated with attractiveness. The effect of av...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Cellerino A

    更新日期：2003-01-01 00:00:00

  • Relation of adiponectin, visfatin and bone mineral density in patients with metabolic syndrome.

    abstract：BACKGROUND:Adipose tissue has been suggested to influence bone density and metabolism through the effect of some adipokines. However, whether adiponectin and visfatin may correlate with bone metabolism is still unclear. AIM:The aim of this study was to investigate the relationship of adiponectin and visfatin with bone...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346703

    authors： Iacobellis G,Iorio M,Napoli N,Cotesta D,Zinnamosca L,Marinelli C,Petramala L,Minisola S,D'Erasmo E,Letizia C

    更新日期：2011-01-01 00:00:00

  • Assessment of non-traumatic vertebral fractures in Cushing's syndrome patients.

    abstract：PURPOSE:Hypercortisolism has detrimental effects on bone metabolism with the consequences of bone loss and bone fractures. We aimed to evaluate the frequency of vertebral fragility fractures and to determine the factors associated with Cushing's syndrome (CS). METHODS:A total of 135 patients diagnosed with Cushing's s...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-020-01496-y

    authors： Apaydın T,Yavuz DG

    更新日期：2021-01-09 00:00:00

  • Correction to: In memory of Professor Domenico Andreani.

    abstract：:Unfortunately, the author name and his affiliation were published in the original publication. They have now been removed. ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s40618-019-01012-x

    authors：

    更新日期：2019-02-01 00:00:00

  • Role of serotoninergic receptors in gonadotropin secretion in male rats.

    abstract：:Experimental data concerning the role of serotonin (5-HT) in the control of gonadotropins secretion remain controversial: different receptors subtypes should mediate the serotoninergic action. In the present work we analyzed in prepubertal and adult male rats the FSH and LH responses after administration of the follow...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347993

    authors： Pinilla L,Tena-Sempere M,Aguilar E

    更新日期：1997-07-01 00:00:00

  • Weight loss and sex steroid metabolism in massively obese man.

    abstract：:To evaluate the effect of weight loss and diet therapy on plasma sex hormone behavior in male obesity, 9 men with a BMI of 43.4 +/- 6.3 participated in an 8-week semistarvation program [whose energy content ranged from 320 to 500 k calorie/day (proteins 44 to 60 g and carbohydrates 54 to 81 g per day)] followed by a t...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350136

    authors： Pasquali R,Casimirri F,Melchionda N,Fabbri R,Capelli M,Platè L,Patrono D,Balestra V,Barbara L

    更新日期：1988-03-01 00:00:00

  • The inhibitory effects of PKCθ on adiponectin expression is mediated by ERK in 3T3-L1 adipocytes.

    abstract：:The research suggests that adiponectin plays an important role in sensitizing insulin action. It is interesting to find that the lower levels of adiponectin exist in the plasma of obese and Type 2 diabetes subjects and in the adipose tissue of obese, db/db mice, and insulin-resistant individuals. However, the underlyi...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346688

    authors： Sun S,Liu Y,Lu J,Omar A,Sun S,Bi Y,Wang C

    更新日期：2011-01-01 00:00:00

  • Testosterone, body composition and aging.

    abstract：:In addition to growth hormone (GH), sex hormones are important determinants of body composition. Aging is accompanied by a decrease in free testosterone levels and, as BMI as well as fat mass increase with age (with a redistribution of body fat), whereas muscle mass decreases, it is tempting to attribute a causal role...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Vermeulen A,Goemaere S,Kaufman JM

    更新日期：1999-01-01 00:00:00

  • Papillary thyroid carcinoma: occurrence and types of lymph node metastases.

    abstract：:Fifty-seven (35.6%) of 160 patients with papillary thyroid carcinoma had lymph node metastases at the primary treatment. Children and adolescents were most frequently affected (69.2%), followed by the age group of 21-40-year olds (38.8%). Those older than 40 had the lowest incidence of lymph node metastases (29.6%; p ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346863

    authors： Ahuja S,Ernst H,Lenz K

    更新日期：1991-07-01 00:00:00

  • A study on the hyperinsulinism of late pregnancy.

    abstract：:Much research has demonstrated that in late pregnancy glucose administration causes a marked increase of peripheral insulin levels. To ascertain whether this particular increase is due to increased insulin secretion and/or to reduced hepatic insulin removal, we measured blood glucose, plasma C-peptide and plasma insul...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347933

    authors： Piva I,Erle G,Thiella M,Lora L,Strazzabosco M,Sicolo N,Federspil G

    更新日期：1991-11-01 00:00:00

  • Glucose-stimulated insulin secretion: Effects of high-fat diet and acute stress.

    abstract：BACKGROUND:One of the major topics in modern societies is the study of relationships between diet, stress and incidence of metabolic disorders. AIM:This study aimed to investigate possible impairment in glucose-stimulated insulin secretion induced by a high-fat (cow intra-abdominal fat) diet in response to acute stres...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/8959

    authors： Ghalami J,Zardooz H,Rostamkhani F,Farrokhi B,Hedayati M

    更新日期：2013-11-01 00:00:00

  • Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhood.

    abstract：:Ghrelin, a natural GH secretagogue, exerts remarkable endocrine and non-endocrine activities such as orexigenic effect and modulation of the endocrine and metabolic response to variations in energy balance. Ghrelin levels have been reported to be negatively associated to insulin secretion, enhanced in anorexia and red...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03344026

    authors： Bellone S,Rapa A,Vivenza D,Castellino N,Petri A,Bellone J,Me E,Broglio F,Prodam F,Ghigo E,Bona G

    更新日期：2002-05-01 00:00:00

  • The SUBITO-DE study: sexual dysfunction in newly diagnosed type 2 diabetes male patients.

    abstract：INTRODUCTION:No data on the prevalence of erectile dysfunction (ED) in subjects with newly diagnosed Type 2 diabetes mellitus (T2DM) are currently available. AIM:The aim of the present study was to estimate the prevalence of ED and its associated causes in a sample of male patients with recently diagnosed DM (<24 mont...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/8969

    authors： Corona G,Giorda CB,Cucinotta D,Guida P,Nada E,SUBITO-DE study group.

    更新日期：2013-11-01 00:00:00

  • Reduced serum thyroglobulin response to bovine TSH in malignant hypofunctioning solid thyroid nodules: comparison to benign nodular disease.

    abstract：:Forty-three euthyroid patients with a single, solid, nonfunctioning thyroid nodule were submitted to fine needle aspiration biopsy and serum thyroglobulin (Tg) was measured before and after (48h) 10 U of bovine TSH. Twenty-two normal subjects were also submitted to the bTSH test. Patients with nonfunctioning nodules w...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348125

    authors： Leite Z,Carneiro P,Halpern A,Medeiros-Neto G

    更新日期：1987-06-01 00:00:00