Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis.

abstract：:Malignant pleural mesothelioma (MPM) usually develops pleural fluid. We investigated the value of DNA methylation in the pleural fluid for differentiating MPM from lung cancer (LC). Pleural fluid was collected from 39 patients with MPM, 46 with LC, 25 with benign asbestos pleurisy (BAP) and 30 with other causes. The m...

journal_title：Cancer science

authors： Fujii M,Fujimoto N,Hiraki A,Gemba K,Aoe K,Umemura S,Katayama H,Takigawa N,Kiura K,Tanimoto M,Kishimoto T

更新日期：2012-03-01 00:00:00

abstract：:Ubiquitin-specific protease 22 (USP22) is a member of the "death-from-cancer" signature, which plays a key role in cancer progression. Previous evidence has shown that USP22 is overexpressed and correlates with poor prognosis in glioma. The effect and mechanism of USP22 in glioma malignancy, especially cancer stemness...

journal_title：Cancer science

authors： Qiu GZ,Mao XY,Ma Y,Gao XC,Wang Z,Jin MZ,Sun W,Zou YX,Lin J,Fu HL,Jin WL

更新日期：2018-07-01 00:00:00

abstract：:Ovarian cancer is the most lethal gynecological malignancy because of its poor prognosis. The Warburg effect is one of the key mechanisms mediating cancer progression. Molecules targeting the Warburg effect are therefore of significant therapeutic value for the treatment of cancers. Many microRNAs (miR) are dysregulat...

journal_title：Cancer science

authors： Zhang S,Pei M,Li Z,Li H,Liu Y,Li J

更新日期：2018-09-01 00:00:00

abstract：:Centrosomes play pivotal roles in cell polarity, regulation of the cell cycle and chromosomal segregation. Centrosome amplification was recently described as a possible cause of aneuploidy in certain solid tumors and leukemias. ATL is a T-cell malignancy caused by HTLV-1. Although the precise mechanism of cell transfo...

journal_title：Cancer science

authors： Nitta T,Kanai M,Sugihara E,Tanaka M,Sun B,Nagasawa T,Sonoda S,Saya H,Miwa M

更新日期：2006-09-01 00:00:00

abstract：:Recurrence and chemoresistance in colorectal cancer remain important issues for patients treated with conventional therapeutics. Metformin and phenformin, previously used in the treatment of diabetes, have been shown to have anticancer effects in various cancers, including breast, lung and prostate cancers. However, t...

journal_title：Cancer science

authors： Park JH,Kim YH,Park EH,Lee SJ,Kim H,Kim A,Lee SB,Shim S,Jang H,Myung JK,Park S,Lee SJ,Kim MJ

更新日期：2019-09-01 00:00:00

abstract：:In several malignant tumors including lymphoma, macrophages that infiltrate tumor tissues are called tumor-associated macrophages (TAMs). We discovered that TAMs, especially the CD163⁺ alternatively activated phenotype (M2), were closely involved with progression of adult T-cell leukemia/lymphoma (ATLL). We used CD68 ...

journal_title：Cancer science

authors： Komohara Y,Niino D,Saito Y,Ohnishi K,Horlad H,Ohshima K,Takeya M

更新日期：2013-07-01 00:00:00

abstract：:Breast cancer is one of the most common malignant diseases in women. Triple-negative breast cancer (TNBC) shows higher aggressiveness and recurrence rates than other subtypes, and there are no effective targets or tailored treatments for TNBC patients. Thus, finding effective prognostic markers for TNBC could help cli...

journal_title：Cancer science

authors： Yao L,Liu Y,Cao Z,Li J,Huang Y,Hu X,Shao Z

更新日期：2018-07-01 00:00:00

abstract：:Chemoresistance, the major obstacle in breast cancer chemotherapy, results in unnecessary chemotherapy and wasting of medical resources. No feasible method has been available to predict chemoresistance before chemotherapy. In our previous study, elevated expression of transient receptor potential channel TRPC5 was fou...

journal_title：Cancer science

authors： Wang T,Ning K,Lu TX,Sun X,Jin L,Qi X,Jin J,Hua D

更新日期：2017-03-01 00:00:00

abstract：:Esophageal squamous cell cancer (ESCC) is one of the most common lethal tumors in the world, and development of new diagnostic and therapeutic methods is needed. In this study, cancer-testis antigen, BORIS, was isolated by functional cDNA expression cloning using screening technique with serum IgG Abs from ESCC patien...

journal_title：Cancer science

authors： Okabayashi K,Fujita T,Miyazaki J,Okada T,Iwata T,Hirao N,Noji S,Tsukamoto N,Goshima N,Hasegawa H,Takeuchi H,Ueda M,Kitagawa Y,Kawakami Y

更新日期：2012-09-01 00:00:00

abstract：:Liver kinase B1 (LKB1) as a tumor suppression gene that is associated with various kinds of cancers, including lung cancer. In this study, we found that the effect of LKB1 on tumor growth was dependent on its subcellular expression in A549 and HCC827 cells. Full-length LKB1 decreased the proliferation and clonogenicit...

journal_title：Cancer science

authors： Liu M,Jiang L,Fu X,Wang W,Ma J,Tian T,Nan K,Liang X

更新日期：2018-10-01 00:00:00

abstract：:Hepatoma-derived growth factor (HDGF) is related to tumorigenesis and the development of cancer; it is an independent factor associated with the prognosis of liver cancer, non-small cell lung cancer and pancreatic cancer. However, the molecular mechanism by which HDGF participates in gastric carcinogenesis and develop...

journal_title：Cancer science

authors： Mao J,Xu Z,Fang Y,Wang H,Xu J,Ye J,Zheng S,Zhu Y

更新日期：2008-11-01 00:00:00

abstract：:In vivo monitoring of conditionally replicative adenovirus (CRAd) replication and assessing its correlation to CRAd biological effects are necessary for the clinical development of gene therapy. Noninvasive bioimaging is one current approach which can monitor in vivo CRAd replication and functional effect. Here we des...

journal_title：Cancer science

authors： Davydova J,Gavrikova T,Brown EJ,Luo X,Curiel DT,Vickers SM,Yamamoto M

更新日期：2010-02-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a lethal malignancy. However, there are few useful markers for diagnosis and treatment. Glutathione S-transferase Pi 1 (GSTP1) has been reported as a predictor of malignancy or anticancer drug resistance in some cancers. We investigated the association of GSTP1 expression w...

journal_title：Cancer science

authors： Ogino S,Konishi H,Ichikawa D,Matsubara D,Shoda K,Arita T,Kosuga T,Komatsu S,Shiozaki A,Okamoto K,Kishimoto M,Otsuji E

更新日期：2019-02-01 00:00:00

abstract：:Lung adenocarcinoma with micropapillary pattern (MPP) has an aggressive malignant behavior. Limited resection should be avoided because of its high recurrence rate. If adenocarcinoma with MPP is diagnosed preoperatively, the selection of proper treatment is possible. To explore a preoperative biomarker for diagnosing ...

journal_title：Cancer science

authors： Sata Y,Nakajima T,Fukuyo M,Matsusaka K,Hata A,Morimoto J,Rahmutulla B,Ito Y,Suzuki H,Yoshino I,Kaneda A

更新日期：2020-07-01 00:00:00

abstract：:An association between deregulation of homeobox (HOX) gene expression and oncogenic transformation has been recently reported in human tumors. In this study, we investigated HOX gene expression and mutation in cervical carcinoma cells. Using reverse transcription-PCR, 11 human cervical carcinoma cell lines and 14 norm...

journal_title：Cancer science

authors： Hung YC,Ueda M,Terai Y,Kumagai K,Ueki K,Kanda K,Yamaguchi H,Akise D,Ueki M

更新日期：2003-05-01 00:00:00

abstract：:Occupational asbestos exposure occurs in many workplaces and is a well-known cause of mesothelioma and lung cancer. However, the association between nonoccupational asbestos exposure and those diseases is not clearly described. The aim of this study was to investigate cause-specific mortality among the residents of Am...

journal_title：Cancer science

authors： Zha L,Kitamura Y,Kitamura T,Liu R,Shima M,Kurumatani N,Nakaya T,Goji J,Sobue T

更新日期：2019-03-01 00:00:00

abstract：:Tumors require blood supply and, to overcome this restriction, induce angiogenesis. Vascular endothelial growth factor (VEGF) plays an important role in this process, which explains the great number of antiangiogenic therapies targeting VEGF. The research and development of targeted therapy has led to the approval of ...

journal_title：Cancer science

authors： Sanches Jde S,de Aguiar RB,Parise CB,Suzuki JM,Chammas R,de Moraes JZ

更新日期：2016-04-01 00:00:00

abstract：:The usual primary endpoint in clinical trials for first-line chemotherapy in advanced non-small cell lung cancer is overall survival. Second-line chemotherapy can also prolong overall survival. Non-smoking history has been associated with a treatment effect for epidermal growth factor receptor-tyrosine kinase inhibito...

journal_title：Cancer science

authors： Itaya T,Yamaoto N,Ando M,Ebisawa M,Nakamura Y,Murakami H,Asai G,Endo M,Takahashi T

更新日期：2007-02-01 00:00:00

abstract：:The Japanese-German Workshops "Molecular and Cellular Aspects of Carcinogenesis," held biennially since 1987, have been organized traditionally at the University of Essen Medical School and West German Cancer Center Essen in Germany. This 9th Workshop was held on September 18-20, 2003. It was generously supported by t...

journal_title：Cancer science

authors： Miyazono K,Ishikawa F,Winterhager E,Deppert W,Rajewsky MF

更新日期：2004-03-01 00:00:00

abstract：:The sentinel node (SN) concept has been found to be feasible in gastric cancer. However, the lymphatic network of gastric cancer may be more complex, and it may be difficult to visualize all the SN distributed in unexpected areas by conventional modalities. In this study, we evaluate the feasibility and efficacy of CT...

journal_title：Cancer science

authors： Tsujimoto H,Yaguchi Y,Sakamoto N,Kumano I,Takahata R,Matsumoto Y,Yoshida K,Sugasawa H,Ono S,Ichikura T,Yamamoto J,Hase K

更新日期：2010-12-01 00:00:00

abstract：:SALL4 is overexpressed in many cancers and is found to be involved in tumorigenesis and tumor progression. However, the function of SALL4 in cervical cancer remains unknown. Here, we showed that the expression of SALL4 was gradually increased from normal cervical tissue to high-grade squamous intraepithelial lesions a...

journal_title：Cancer science

authors： Chen M,Li L,Zheng PS

更新日期：2019-09-01 00:00:00

abstract：:It is generally accepted that recurrent chromosome translocations play a major role in the molecular pathogenesis of hematological malignancies but not of solid tumors. However, chromosome translocations involving the e26 transformation-specific sequence transcription factor loci have been demonstrated recently in man...

journal_title：Cancer science

authors： Mano H

更新日期：2008-12-01 00:00:00

abstract：:Adult long-term hematopoiesis depends on sustaining hematopoietic stem/progenitor cells (HSPC) in bone marrow (BM) niches, where their balance of quiescence, self-renewal, and hematopoietic differentiation is tightly regulated. Although various BM stroma cells that produce niche factors have been identified, regulatio...

journal_title：Cancer science

authors： Imai T,Tanaka H,Hamazaki Y,Minato N

更新日期：2019-04-01 00:00:00

abstract：:To elucidate a role of ΔNp63α in breast cancer, the expression levels of p63, estrogen receptor, progesterone receptor, p53, CK5, cerBb-2, and Notch1 were assayed in 50 clinical breast cancer specimens using immunochemistry. P63 was highly expressed in a subset of breast cancer with basal-like features. We then transf...

journal_title：Cancer science

authors： Du Z,Li J,Wang L,Bian C,Wang Q,Liao L,Dou X,Bian X,Zhao RC

更新日期：2010-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) are produced through normal cellular metabolism, and their formation is further enhanced by exposure to ionizing radiation and various chemicals. ROS attack DNA, and the resulting oxidative DNA damage is considered to contribute to aging, carcinogenesis and neurodegeneration. Among variou...

journal_title：Cancer science

authors： Tsuzuki T,Nakatsu Y,Nakabeppu Y

更新日期：2007-04-01 00:00:00

abstract：:Recent studies have shown that selective cyclooxygenase-2 (COX-2) inhibitors induce growth inhibition and cell cycle arrest in hepatocellular carcinoma (HCC) cell lines. However, the mechanism by which COX-2 inhibitors regulate the cell cycle and whether or not growth signal pathways are involved in the growth inhibit...

journal_title：Cancer science

authors： Cheng J,Imanishi H,Liu W,Nakamura H,Morisaki T,Higashino K,Hada T

更新日期：2004-08-01 00:00:00

abstract：:Loss of expression of Fhit, a tumor suppressor and genome caretaker, occurs in preneoplastic lesions during development of many human cancers. Furthermore, Fhit-deficient mouse models are exquisitely susceptible to carcinogen induction of cancers of the lung and forestomach. Due to absence of Fhit genome caretaker fun...

journal_title：Cancer science

authors： Paisie CA,Schrock MS,Karras JR,Zhang J,Miuma S,Ouda IM,Waters CE,Saldivar JC,Druck T,Huebner K

更新日期：2016-04-01 00:00:00

abstract：:Over the last few decades, numerous biomarkers in Wilms' tumor have been confirmed and shown variations in prevalence. Most of these studies were based on small sample sizes. We carried out a meta-analysis of the research published from 1992 to 2015 to obtain more precise and comprehensive outcomes for genetic tests. ...

journal_title：Cancer science

authors： Deng C,Dai R,Li X,Liu F

更新日期：2016-05-01 00:00:00

abstract：:Natural killer (NK) cells are innate lymphocytes that rapidly respond to cancer cells without prior sensitization or restriction to the cognate antigen in comparison with tumor antigen-specific T cells. Recent advances in understanding NK-cell biology have elucidated the molecular mechanisms underlying the differentia...

journal_title：Cancer science

authors： Miyazato K,Hayakawa Y

更新日期：2020-06-01 00:00:00

abstract：:Inotuzumab ozogamicin (CMC-544), an antibody-targeted chemotherapeutic agent composed of an anti-CD22 antibody conjugated to calicheamicin, a potent cytotoxic antibiotic, specifically targets the CD22 antigen present in >90% of B-lymphoid malignancies, rendering it useful for treating patients with B-cell non-Hodgkin ...

journal_title：Cancer science

authors： Ogura M,Tobinai K,Hatake K,Uchida T,Kasai M,Oyama T,Suzuki T,Kobayashi Y,Watanabe T,Azuma T,Mori M,Terui Y,Yokoyama M,Mishima Y,Takahashi S,Ono C,Ohata J

更新日期：2010-08-01 00:00:00