Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis.

abstract：:The transcriptional factor hypoxia-inducible factor-1 (HIF-1) plays an important role in solid tumor cell growth and survival. Overexpression of HIF-1alpha has been demonstrated in many human tumors and predicts a poor response to chemoradiotherapy. We examined the HIF-1alpha-induced survival pathways in human oral sq...

journal_title：Cancer science

authors： Sasabe E,Tatemoto Y,Li D,Yamamoto T,Osaki T

更新日期：2005-07-01 00:00:00

abstract：:L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to develop a LAT1-mediated chemotherapeutic agent. We screened doxorubicin modified by seven different large neutral amino acids. The aspartate-modified doxo...

journal_title：Cancer science

authors： Wu W,Dong Y,Gao J,Gong M,Zhang X,Kong W,Li Y,Zeng Y,Si D,Wei Z,Ci X,Jiang L,Li W,Li Q,Yi X,Liu C

更新日期：2015-06-01 00:00:00

abstract：:RNA-binding proteins (RBPs) play fundamental roles in the RNA life cycle. The aberrant expression of RBPs is often observed in human disease, including cancer. In this study, we screened for the expression levels of 1542 human RBPs in The Cancer Genome Atlas liver hepatocellular carcinoma samples and found 92 consiste...

journal_title：Cancer science

authors： Li T,Li S,Chen D,Chen B,Yu T,Zhao F,Wang Q,Yao M,Huang S,Chen Z,He X

更新日期：2017-05-01 00:00:00

abstract：:Discovery of a high-risk group for pancreatic cancer is important for prevention of pancreatic cancer. The present study was conducted as a nested case-control study including 170 pancreatic cancer cases and 340 matched controls of our population-based cohort study involving 30 239 subjects who answered a baseline que...

journal_title：Cancer science

authors： Nakagawa T,Kobayashi T,Nishiumi S,Hidaka A,Yamaji T,Sawada N,Hirata Y,Yamanaka K,Azuma T,Goto A,Shimazu T,Inoue M,Iwasaki M,Yoshida M,Tsugane S

更新日期：2018-05-01 00:00:00

abstract：:Biliary tract cancer (BTC) arises from biliary epithelial cells (BECs) and includes intrahepatic cholangiocarcinoma (IHCC), gallbladder cancer (GC), and extrahepatic cholangiocarcinoma (EHCC). Although frequent KRAS mutations and epigenetic changes at the INK4A/ARF locus have been identified, the molecular pathogenesi...

journal_title：Cancer science

authors： Kasuga A,Semba T,Sato R,Nobusue H,Sugihara E,Takaishi H,Kanai T,Saya H,Arima Y

更新日期：2020-10-17 00:00:00

abstract：:Inhibitor of growth (ING) family proteins have been defined as candidate tumor suppressors for more than a decade. Recent emerging results using siRNA and knockout mice are expanding the previous understanding of this protein family. The results of ING1 knockout mouse experiments revealed that ING1 has a protective ef...

journal_title：Cancer science

authors： Unoki M,Kumamoto K,Takenoshita S,Harris CC

更新日期：2009-07-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) and Hodgkin lymphoma (HL) express CD30 at high levels, but stimulation of this molecule has been reported to induce contradictory effects. To elucidate the molecular mechanism of CD30-mediated apoptosis of ALCL, we compared the gene expression profiles of t(2;5)(p23;q35)-positive ...

journal_title：Cancer science

authors： Nishikori M,Ohno H,Haga H,Uchiyama T

更新日期：2005-08-01 00:00:00

abstract：:The antitumor effects of tumor necrosis factor (TNF-α) were evaluated following transfection of TNF-α plasmid DNA into solid mouse tumors using the nanobubbles (NBs) and ultrasound (US) gene delivery system. Murine breast carcinoma (EMT6) cells expressing luciferase (1 × 10(6) cells) were injected intradermally into t...

journal_title：Cancer science

authors： Horie S,Watanabe Y,Ono M,Mori S,Kodama T

更新日期：2011-11-01 00:00:00

abstract：:Uniform antibody microdistribution throughout tumor nodules is crucial for antibody-targeted therapy, because non-uniform microdistribution leads to suboptimal therapeutic effect, a commonly observed limitation of therapeutic antibodies. Herein, we evaluated the microdistribution of different doses of intraperitoneall...

journal_title：Cancer science

authors： Kosaka N,Ogawa M,Paik DS,Paik CH,Choyke PL,Kobayashi H

更新日期：2010-03-01 00:00:00

abstract：:Tumor angiogenesis inhibition is one of the most potent strategies in cancer chemotherapy. From past clinical studies, inhibition of the vascular endothelial growth factor pathway successfully treats malignant tumors. However, vascular endothelial growth factor inhibitors alone cannot cure tumors. Moreover, resistance...

journal_title：Cancer science

authors： Shimazu K,Inoue M,Sugiyama S,Fukuda K,Yoshida T,Taguchi D,Uehara Y,Kuriyama S,Tanaka M,Miura M,Nanjyo H,Iwabuchi Y,Shibata H

更新日期：2018-10-01 00:00:00

abstract：:Telomeres protect chromosome ends from being recognized as DNA double-strand breaks. Telomere shortening, which occurs due to incomplete replication of DNA termini, limits the proliferative capacity of human somatic cells and contributes as a barrier to carcinogenesis. In most human cancer cells, telomerase maintains ...

journal_title：Cancer science

authors： Muramatsu Y,Ohishi T,Sakamoto M,Tsuruo T,Seimiya H

更新日期：2007-06-01 00:00:00

abstract：:This study aims to identify postoperative recurrence patterns of pancreatic cancer with different molecular profiles, which provides evidence for personalized target volumes of adjuvant radiotherapy. Patients with pathologically confirmed resectable pancreatic ductal adenocarcinoma were included. Recurrences were trea...

journal_title：Cancer science

authors： Zhu X,Cao Y,Ju X,Zhao X,Jiang L,Ye Y,Shen Y,Cao F,Qing S,Zhang H

更新日期：2020-05-17 00:00:00

abstract：:Lipoxygenases induce malignant tumor progression and lipoxygenase inhibitors have been considered as promising anti-tumor agents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is one of the most promising candidates for new cancer therapeutics. Combined treatment with nordihydroguaiaretic acid (NDGA)...

journal_title：Cancer science

authors： Yoshida T,Shiraishi T,Horinaka M,Nakata S,Yasuda T,Goda AE,Wakada M,Mizutani Y,Miki T,Nishikawa A,Sakai T

更新日期：2007-09-01 00:00:00

abstract：:Neuroblastoma (NB) is the most common extracranial solid tumor that originates from multipotent neural crest cells. NB cell populations that express embryonic stem cell-associated genes have been identified and shown to retain a multipotent phenotype. However, whether somatic reprogramming of NB cells can produce simi...

journal_title：Cancer science

authors： Islam SM,Suenaga Y,Takatori A,Ueda Y,Kaneko Y,Kawana H,Itami M,Ohira M,Yokoi S,Nakagawara A

更新日期：2015-10-01 00:00:00

abstract：:Estrogen receptor (ER) status is an essential determinant of clinical and biological behavior of human breast cancers. While ER-positive breast cancers respond well to adjuvant hormone therapy, ER-negative tumors are generally resistant. To date, no attempts have succeeded in finding molecular markers for classifying ...

journal_title：Cancer science

authors： Nagahata T,Onda M,Emi M,Nagai H,Tsumagari K,Fujimoto T,Hirano A,Sato T,Nishikawa K,Akiyama F,Sakamoto G,Kasumi F,Miki Y,Tanaka T,Tsunoda T

更新日期：2004-03-01 00:00:00

abstract：:Estrogen receptor (ER)-positive breast cancer is a distinct subpopulation of breast cancer exhibiting a high response rate to endocrine therapy. However, not all ER-positive patients respond to the therapy, and a subgrouping of ER-positive patients based on the physiology of estrogen signaling is expected to be useful...

journal_title：Cancer science

authors： Yoshida N,Omoto Y,Inoue A,Eguchi H,Kobayashi Y,Kurosumi M,Saji S,Suemasu K,Okazaki T,Nakachi K,Fujita T,Hayashi S

更新日期：2004-06-01 00:00:00

abstract：:Tissue factor (TF) is known to be overexpressed in various cancers including pancreatic cancer. The upregulation of TF expression has been observed not only in tumor cells, but also in tumor stromal cells. Because of the potential of TF as a delivery target, several studies investigated the effectiveness of Ab-drug co...

journal_title：Cancer science

authors： Tsumura R,Manabe S,Takashima H,Koga Y,Yasunaga M,Matsumura Y

更新日期：2019-10-01 00:00:00

abstract：:Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication and regulation of p53. In hematological malignancies, the NPM1 gene is frequently involved in chromosomal translocation, mutation and deletion. The NPM...

journal_title：Cancer science

authors： Naoe T,Suzuki T,Kiyoi H,Urano T

更新日期：2006-10-01 00:00:00

abstract：:TLR-9 agonists are immunostimulating agents that have antitumor effects in animal models. A phase I trial was conducted to define the safety profile of subcutaneous injections, combined with intrathecally administration of CpG-28, a TRL 9 agonist, in patients with neoplastic meningitis (NM). Cohorts of 3-6 patients wi...

journal_title：Cancer science

authors： Ursu R,Taillibert S,Banissi C,Vicaut E,Bailon O,Le Rhun E,Guillamo JS,Psimaras D,Tibi A,Sacko A,Marantidou A,Belin C,Carpentier AF

更新日期：2015-09-01 00:00:00

abstract：:Multiple myeloma (MM) is a currently incurable blood cancer. Here we tested the effects of a small compound bigelovin on MM cells, and reported that it caused cell cycle arrest and subsequently induced apoptosis. Bigelovin triggered proteolysis of E2F1, which could be inhibited by caspase inhibitor. To investigate the...

journal_title：Cancer science

authors： Liu JL,Zeng GZ,Liu XL,Liu YQ,Hu ZG,Liu Y,Tan NH,Zhou GB

更新日期：2013-12-01 00:00:00

abstract：:With limited treatment options, intraperitoneal spread of ovarian cancer is a common problem leading to high morbidity. Intraperitoneal photodynamic therapy combined with debulking surgery to treat residual disease is an alternative choice for clinicians. Hematoporphyrin monomethyl ether (HMME) is a promising second-g...

journal_title：Cancer science

authors： Song K,Kong B,Li L,Yang Q,Wei Y,Qu X

更新日期：2007-12-01 00:00:00

abstract：:This phase 1, open-label, dose-escalation study was conducted to determine the safety, tolerability, pharmacokinetics and preliminary efficacy of veliparib with carboplatin and weekly paclitaxel in Japanese women with newly diagnosed, advanced ovarian cancer. Patients received veliparib at 100 or 150 mg b.i.d. on days...

journal_title：Cancer science

authors： Nishio S,Takekuma M,Takeuchi S,Kawano K,Tsuda N,Tasaki K,Takahashi N,Abe M,Tanaka A,Nagasawa T,Shoji T,Xiong H,Nuthalapati S,Leahy T,Hashiba H,Kiriyama T,Komarnitsky P,Hirashima Y,Ushijima K

更新日期：2017-11-01 00:00:00

abstract：:Ret finger protein (RFP) is a nuclear protein with transcriptional repressive activity that is highly expressed in a variety of human and rodent tumor cell lines. We examined the expression of RFP in human endometrial cancer and assessed its clinical significance. Formalin-fixed, paraffin-embedded sections from endome...

journal_title：Cancer science

authors： Tsukamoto H,Kato T,Enomoto A,Nakamura N,Shimono Y,Jijiwa M,Asai N,Murakumo Y,Shibata K,Kikkawa F,Takahashi M

更新日期：2009-10-01 00:00:00

abstract：:Nasal natural killer (NK)/T-cell lymphoma (NKTCL) and chronic active Epstein-Barr virus infection (CAEBV) are relatively frequent, especially in Asia, and are poor in prognosis. Both diseases are proliferative diseases of NK/T cells that show highly complicated karyotypes, suggesting the involvement of chromosomal ins...

journal_title：Cancer science

authors： Liu A,Takakuwa T,Luo WJ,Fujita S,Aozasa K

更新日期：2006-07-01 00:00:00

abstract：:Atrazine, one of the most commonly used herbicides in the world, has been reported to have endocrine disrupting effects in vivo. In the present experiment, influence of dietary atrazine on the late promotion/progression stage of mammary carcinogenesis in ovariectomized female Sprague-Dawley rats was examined after a s...

journal_title：Cancer science

authors： Ueda M,Imai T,Takizawa T,Onodera H,Mitsumori K,Matsui T,Hirose M

更新日期：2005-01-01 00:00:00

abstract：:We present an acute promyelocytic leukemia (APL) patient with two subtypes of IRF2BP2-RARA, in which the IRF2BP2 gene showed completely new breakpoints. Bone marrow examination revealed morphologic features indicative of APL. However, promyelocytic leukemia-RARA fusion was not detected. A paired-end mRNA sequencing fo...

journal_title：Cancer science

authors： Shimomura Y,Mitsui H,Yamashita Y,Kamae T,Kanai A,Matsui H,Ishibashi T,Tanimura A,Shibayama H,Oritani K,Kuyama J,Kanakura Y

更新日期：2016-08-01 00:00:00

abstract：:Dietary factors may affect the prognosis of digestive tract cancer, but evidence has been sparse. We investigated the association between pretreatment intake of 6 Japanese foods (including soy food, miso [soybean paste] soup and seaweed) and the risk of death among patients with histologically confirmed major digestiv...

journal_title：Cancer science

authors： Minami Y,Kanemura S,Oikawa T,Suzuki S,Hasegawa Y,Nishino Y,Fujiya T,Miura K

更新日期：2020-07-01 00:00:00

abstract：:Skin cancer is the most frequently diagnosed cancer in the fair-skinned population. In recent years, the incidence of nonmelanoma skin cancer (NMSC) has been increasing worldwide. However, there is no epidemiological study on skin cancer in the Asian population. A prospective cohort study including 140 420 participant...

journal_title：Cancer science

authors： Cai H,Sobue T,Kitamura T,Sawada N,Iwasaki M,Shimazu T,Tsugane S

更新日期：2020-11-01 00:00:00

abstract：:Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) are effective for non-small cell lung cancers (NSCLC) with EGFR-activating mutations. However, most responders develop resistance. Efatutazone, a novel peroxisome proliferator-activated receptor gamma (PPARγ) agonist, is currently under clinical ev...

journal_title：Cancer science

authors： Serizawa M,Murakami H,Watanabe M,Takahashi T,Yamamoto N,Koh Y

更新日期：2014-06-01 00:00:00

abstract：:Drug resistance is a major concern in the successful treatment of ovarian cancer. In the present study we report a combinational drug regime using arsenic trioxide (ATO) and cisplatin (CDDP) to increase therapeutic potentiality in ovarian cancer cells. ATO-mediated growth inhibition and apoptosis in human suspension o...

journal_title：Cancer science

authors： Zhang N,Wu ZM,McGowan E,Shi J,Hong ZB,Ding CW,Xia P,Di W

更新日期：2009-12-01 00:00:00