Interventions for rosacea.


BACKGROUND:Rosacea is a common skin condition affecting the face, characterised by flushing, redness, pimples, pustules and dilated blood vessels. The eyes are often also involved. The cause of rosacea is unclear. It is a chronic disease, which can be controlled in most cases with appropriate treatment. Numerous treatments are in use although it is unclear which are best, and which are most appropriate for the different types of rosacea. OBJECTIVES:To assess and summarise current evidence for the efficacy and safety of treatments for rosacea. SEARCH STRATEGY:We searched the Skin Group Specialised Trials Register (March 2002), Cochrane Central Register of Controlled Trials (CENTRAL, March 2002), MEDLINE (from 1966 to March 2002), EMBASE (from 1980 to March 2002), Biosis (from 1970 to March 2002) and the Science Citation Index (from 1988 to March 2002). Reference lists of trials and key review articles were also searched. Relevant manufacturers and experts were contacted. SELECTION CRITERIA:Randomised controlled trials in people with moderate to severe rosacea were included. Studies judged by the reviewers to have seriously flawed methodology were excluded. DATA COLLECTION AND ANALYSIS:Study selection, assessment of methodological quality, data extraction and analysis were carried out by two independent reviewers. MAIN RESULTS:The evidence provided by twenty-two included studies was generally weak because of poor methodology and reporting. One of our primary outcome measures, 'quality of life', was not assessed in any of the studies. Only two studies of ocular rosacea could be included. Pooled data from two trials involving 174 participants indicated that topical metronidazole is more effective than placebo (odds ratio 5.96, 95% confidence interval 2.95 to 12.06). Data from a between-patient trial (114 patients) and a within-patient trial (33 patients) of azelaic cream versus placebo were not pooled, but both showed good evidence of efficacy. Data pooled from three studies of oral tetracycline versus placebo involving 152 participants showed that, according to physicians' ratings, tetracycline was effective (odds ratio 6.06, 95% confidence interval 2.96 to 12.42). Some evidence of efficacy of oral metronidazole was provided by one small study. REVIEWER'S CONCLUSIONS:The quality of studies evaluating rosacea treatments was generally poor. There is evidence that topical metronidazole and azelaic acid cream have a therapeutic effect. There is some evidence that oral metronidazole and tetracycline are effective. There is insufficient evidence concerning the effectiveness of other treatments. As many of these treatments are used for rosacea, good RCTs are urgently needed.


van Zuuren EJ,Graber MA,Hollis S,Chaudhry M,Gupta AK





Has Abstract


2004-01-01 00:00:00








  • Topical antiseptics for chronic suppurative otitis media.

    abstract:BACKGROUND:Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and infection of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM are ear discharge and...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Head K,Chong LY,Bhutta MF,Morris PS,Vijayasekaran S,Burton MJ,Schilder AG,Brennan-Jones CG

    更新日期:2020-01-06 00:00:00

  • Interventions for preventing delirium in hospitalised patients.

    abstract:BACKGROUND:Delirium is a common mental disorder with serious adverse outcomes in hospitalised patients. It is associated with increases in mortality, physical morbidity, length of hospital stay, institutionalisation and costs to healthcare providers. A range of risk factors has been implicated in its aetiology, includi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Siddiqi N,Stockdale R,Britton AM,Holmes J

    更新日期:2007-04-18 00:00:00

  • Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults.

    abstract:BACKGROUND:Disease-related malnutrition has been reported in 10% to 55% of people in hospital and the community. Dietary advice encouraging the use of energy- and nutrient-rich foods rather than oral nutritional supplements has been suggested as the initial approach for managing disease-related malnutrition. OBJECTIVE...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章


    authors: Baldwin C,Weekes CE

    更新日期:2011-09-07 00:00:00

  • WITHDRAWN: Prostaglandins versus oxytocin for prelabour rupture of membranes at term.

    abstract:BACKGROUND:The conventional method of induction of labour is with intravenous oxytocin. More recently, induction with prostaglandins, followed by an infusion of oxytocin if necessary, has been used. OBJECTIVES:The objective of this review was to assess the effects of induction of labour with prostaglandins versus oxyt...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Tan BP,Hannah ME

    更新日期:2007-07-18 00:00:00

  • Carnitine supplementation of parenterally fed neonates.

    abstract:BACKGROUND:Carnitine, a quaternary amino acid, plays an important role in the oxidation of long chain fatty acids. Both breast milk and infant formulas contain carnitine. However, it is not routinely provided in parenteral nutrition solutions. Non supplemented parenterally fed infants have very low tissue carnitine lev...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Cairns PA,Stalker DJ

    更新日期:2000-01-01 00:00:00

  • Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications.

    abstract:BACKGROUND:This is an update of the review last published in 2011. It focuses on early postoperative enteral nutrition after lower gastrointestinal surgery. Traditional management consisted of 'nil by mouth', where patients receive fluids followed by solids after bowel function has returned. Although several trials hav...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Herbert G,Perry R,Andersen HK,Atkinson C,Penfold C,Lewis SJ,Ness AR,Thomas S

    更新日期:2018-10-24 00:00:00

  • Cognitive behaviour therapy for schizophrenia.

    abstract:BACKGROUND:Although medication is the mainstay of treatment for schizophrenia, always, some sort of informal or formal talking therapy is indicated. In cognitive behavioural therapy (CBT) links are made between the person's feelings and patterns of thinking which underpin their distress. OBJECTIVES:To review the effec...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Jones C,Cormac I,Mota J,Campbell C

    更新日期:2000-01-01 00:00:00

  • Reduction in saturated fat intake for cardiovascular disease.

    abstract:BACKGROUND:Reducing saturated fat reduces serum cholesterol, but effects on other intermediate outcomes may be less clear. Additionally, it is unclear whether the energy from saturated fats eliminated from the diet are more helpfully replaced by polyunsaturated fats, monounsaturated fats, carbohydrate or protein. OBJE...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Hooper L,Martin N,Jimoh OF,Kirk C,Foster E,Abdelhamid AS

    更新日期:2020-05-19 00:00:00

  • Beta2-agonists for acute bronchitis.

    abstract:BACKGROUND:There are no clearly effective treatments for the cough of acute bronchitis, and beta2-agonists are often prescribed, perhaps because clinicians suspect many patients also have reversible airflow restriction contributing to the symptoms. OBJECTIVES:To determine whether beta2-agonists improve symptoms of acu...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Smucny J,Becker L,Glazier R

    更新日期:2006-10-18 00:00:00

  • Antibiotic regimens for the empirical treatment of newborn infants with necrotising enterocolitis.

    abstract:BACKGROUND:Although the exact aetiology of necrotising enterocolitis (NEC) remains unknown, research suggests that it is multifactorial; suspected pathophysiological mechanisms include immaturity, intestinal ischaemia, disruption of intestinal mucosal integrity, formula feeding, hyperosmolar load to the intestine, infe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Shah D,Sinn JK

    更新日期:2012-08-15 00:00:00

  • Treatment for amphetamine withdrawal.

    abstract:BACKGROUND:Amphetamine withdrawal has been less studied although it is a common problem with a prevalent rate of 87% among amphetamine users. Its symptoms, in particular intense craving, may be a critical factor leading to relapse of amphetamine use. In clinical practice, treatment for cocaine withdrawal has been recom...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Srisurapanont M,Jarusuraisin N,Kittirattanapaiboon P

    更新日期:2001-01-01 00:00:00

  • Bezafibrate for primary biliary cirrhosis.

    abstract:BACKGROUND:Treatment of primary biliary cirrhosis is complicated. There are studies suggesting that bezafibrate, alone or in combination with ursodeoxycholic acid (UDCA), is effective in the treatment of primary biliary cirrhosis, but no systematic review has summarised the evidence yet. OBJECTIVES:To assess the benef...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Rudic JS,Poropat G,Krstic MN,Bjelakovic G,Gluud C

    更新日期:2012-01-18 00:00:00

  • Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain.

    abstract:BACKGROUND:There is increasing focus on providing high quality care for people at the end of life, irrespective of disease or cause, and in all settings. In the last ten years the use of care pathways to aid those treating patients at the end of life has become common worldwide. The use of the Liverpool Care Pathway in...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Wiffen PJ,Derry S,Moore RA

    更新日期:2014-05-29 00:00:00

  • Delayed antibiotics for respiratory infections.

    abstract:BACKGROUND:Concerns exist regarding antibiotic prescribing for acute respiratory tract infections (ARTIs) owing to adverse reactions, cost and antibacterial resistance. One strategy to reduce antibiotic prescribing is to provide prescriptions but to advise delay in the hope symptoms will resolve first. This is an updat...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Spurling GK,Del Mar CB,Dooley L,Foxlee R,Farley R

    更新日期:2013-04-30 00:00:00

  • Intra-articular corticosteroid for knee osteoarthritis.

    abstract:BACKGROUND:Knee osteoarthritis is a leading cause of chronic pain, disability, and decreased quality of life. Despite the long-standing use of intra-articular corticosteroids, there is an ongoing debate about their benefits and safety. This is an update of a Cochrane review first published in 2005. OBJECTIVES:To deter...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Jüni P,Hari R,Rutjes AW,Fischer R,Silletta MG,Reichenbach S,da Costa BR

    更新日期:2015-10-22 00:00:00

  • Artesunate versus quinine for treating severe malaria.

    abstract:BACKGROUND:Severe malaria kills over a million people every year. We sought evidence of superiority of artesunate compared with the standard treatment quinine. OBJECTIVES:To compare artesunate with quinine for treating severe malaria. SEARCH STRATEGY:We searched the Cochrane Infectious Diseases Group Specialized Regi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Jones KL,Donegan S,Lalloo DG

    更新日期:2007-10-17 00:00:00

  • Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults.

    abstract:BACKGROUND:Migraine is a common, disabling condition and a burden for the individual, health services and society. Many sufferers choose not to, or are unable to, seek professional help and rely on over-the-counter analgesics. Co-therapy with an antiemetic should help to reduce nausea and vomiting commonly associated w...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Derry S,Moore RA,McQuay HJ

    更新日期:2010-11-10 00:00:00

  • Combination inhaled steroid and long-acting beta(2)-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease.

    abstract:BACKGROUND:The long-acting bronchodilator tiotropium and single inhaler combination therapy of inhaled corticosteroids and long-acting beta(2)-agonists are both commonly used for maintenance treatment of chronic obstructive pulmonary disease. Combining these treatments, which have different mechanisms of action, may be...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Karner C,Cates CJ

    更新日期:2011-03-16 00:00:00

  • Psychological interventions for needle-related procedural pain and distress in children and adolescents.

    abstract:BACKGROUND:This is the second update of a Cochrane Review (Issue 4, 2006). Pain and distress from needle-related procedures are common during childhood and can be reduced through use of psychological interventions (cognitive or behavioral strategies, or both). Our first review update (Issue 10, 2013) showed efficacy of...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Birnie KA,Noel M,Chambers CT,Uman LS,Parker JA

    更新日期:2018-10-04 00:00:00

  • Nicotine replacement therapy for smoking cessation.

    abstract:BACKGROUND:The aim of nicotine replacement therapy (NRT) is to temporarily replace much of the nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms, thus easing the transition from cigarette smoking to complete abstinence. OBJECTIVES:The aims of this review were: To determine the eff...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Stead LF,Perera R,Bullen C,Mant D,Hartmann-Boyce J,Cahill K,Lancaster T

    更新日期:2012-11-14 00:00:00

  • Media-delivered cognitive behavioural therapy and behavioural therapy (self-help) for anxiety disorders in adults.

    abstract:BACKGROUND:Anxiety disorders are the most common mental health problems. They are chronic and unremitting. Effective treatments are available, but access to services is limited. Media-delivered behavioural and cognitive behavioural interventions (self-help) aim to deliver treatment with less input from professionals co...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Mayo-Wilson E,Montgomery P

    更新日期:2013-09-09 00:00:00

  • Herbal medicines for viral myocarditis.

    abstract:BACKGROUND:Herbal medicines are being used as a treatment for viral diseases such as viral myocarditis and numerous clinical trials have been conducted to investigate their efficacy. Despite this wealth of evidence, the role of herbal medicines in the treatment of viral myocarditis is yet to be established. This is an ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Liu ZL,Liu ZJ,Liu JP,Kwong JS

    更新日期:2012-11-14 00:00:00

  • Posture and fluids for preventing post-dural puncture headache.

    abstract:BACKGROUND:Potentially disabling postural headache occurs after dural puncture in 1-70% of patients. It has been suggested that such headaches may be less common if patients routinely have a period of bed rest or receive supplementary fluids after the procedure. OBJECTIVES:To assess the effects on post dural puncture ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Sudlow C,Warlow C

    更新日期:2002-01-01 00:00:00

  • Interventions for American cutaneous and mucocutaneous leishmaniasis.

    abstract:BACKGROUND:On the American continent, cutaneous and mucocutaneous leishmaniasis (CL and MCL) are diseases associated with infection by several species of Leishmania parasites. Pentavalent antimonials remain the first-choice treatment. There are alternative interventions, but reviewing their effectiveness and safety is ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Pinart M,Rueda JR,Romero GA,Pinzón-Flórez CE,Osorio-Arango K,Silveira Maia-Elkhoury AN,Reveiz L,Elias VM,Tweed JA

    更新日期:2020-08-27 00:00:00

  • Anti-vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis in fetal life. Recently, researchers have attempted to use anti-VEGF agents for the treatment of retinopathy of prematurity (ROP), a vasoproliferative disorder. There is currently uncertainty regarding the safety and efficacy of these...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Sankar MJ,Sankar J,Mehta M,Bhat V,Srinivasan R

    更新日期:2016-01-01 00:00:00

  • Moderately early (7-14 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants.

    abstract:BACKGROUND:Corticosteroids have been used late in the neonatal period to treat chronic lung disease (CLD) in preterm babies, and early to try to prevent it. CLD is likely to be the result of persisting inflammation in the lung and the use of powerful anti-inflammatory drugs like dexamethasone has some rationale. Early ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Halliday HL,Ehrenkranz RA,Doyle LW

    更新日期:2003-01-01 00:00:00

  • Dressings for the prevention of surgical site infection.

    abstract:BACKGROUND:Surgical wounds (incisions) heal by primary intention when the wound edges are brought together and secured - often with sutures, staples, clips or glue. Wound dressings, usually applied after wound closure, provide physical support, protection from bacterial contamination and absorb exudate. Surgical site i...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Dumville JC,Walter CJ,Sharp CA,Page T

    更新日期:2011-07-06 00:00:00

  • Strategies for expanding health insurance coverage in vulnerable populations.

    abstract:BACKGROUND:Health insurance has the potential to improve access to health care and protect people from the financial risks of diseases. However, health insurance coverage is often low, particularly for people most in need of protection, including children and other vulnerable populations. OBJECTIVES:To assess the effe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Jia L,Yuan B,Huang F,Lu Y,Garner P,Meng Q

    更新日期:2014-11-26 00:00:00

  • Surfactant therapy for bronchiolitis in critically ill infants.

    abstract:BACKGROUND:Viral bronchiolitis is a common cause of respiratory failure in infants and children, and accounts for a significant portion of intensive care unit (ICU) admissions during seasonal epidemics. Currently there is no evidence to support the use of anything but supportive care for this disease. Surfactant is a p...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Ventre K,Haroon M,Davison C

    更新日期:2006-07-19 00:00:00

  • Vaccines for women to prevent neonatal tetanus.

    abstract:BACKGROUND:Tetanus is an acute, often fatal, disease caused by an exotoxin produced by Clostridium tetani. It occurs in newborn infants born to mothers who do not have sufficient circulating antibodies to protect the infant passively, by transplacental transfer. Prevention may be possible by the vaccination of pregnant...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Demicheli V,Barale A,Rivetti A

    更新日期:2013-05-31 00:00:00